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    UBA6 ubiquitin-like modifier activating enzyme 6 [ Homo sapiens ]

    Gene ID: 55236, updated on 11-May-2012
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    Summary

    Official Symbol
    UBA6provided by HGNC
    Official Full Name
    ubiquitin-like modifier activating enzyme 6provided by HGNC
    Primary source
    HGNC:25581
    See related
    Ensembl:ENSG00000033178; HPRD:13341; MIM:611361; Vega:OTTHUMG00000129299
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    E1-L2; MOP-4; UBE1L2; FLJ10808; FLJ23367
    Summary
    Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al., 2007 [PubMed 17597759]).[supplied by OMIM, Mar 2008]
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    Genomic context

    Location :
    4q13.2
    Sequence :
    Chromosome: 4; NC_000004.11 (68481479..68566889, complement)
    See UBA6 in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene centromere protein C 1 Neighboring gene signal transducing adaptor family member 1 Neighboring gene uncharacterized LOC550112 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 1 pseudogene Neighboring gene HEAT repeat containing 2 pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling. Xu G, et al. Nat Biotechnol, 2010 Aug. PMID 20639865.
    5. Activating the ubiquitin family: UBA6 challenges the field. Groettrup M, et al. Trends Biochem Sci, 2008 May. PMID 18353650.

    See all (20) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Ubiquitin-like modifier activating enzyme 6 activates not only ubiquitin, but also the ubiquitin-like modifier FAT10[review]
      Title: Activating the ubiquitin family: UBA6 challenges the field.
    2. The identification of an E1-like protein, termed E1-L2, that activates both ubiquitin and another ubiquitin-like protein, FAT10, is reported.
      Title: E1-L2 activates both ubiquitin and FAT10.
    3. UBE1L2 is a novel E1 enzyme specific for ubiquitin
      Title: UBE1L2, a novel E1 enzyme specific for ubiquitin.
    4. Human Uba6 and Ube1 have distinct preferences for E2 charging in vitro, and their specificity depends in part on their C-terminal ubiquitin-fold domains, which recruit E2s
      Title: Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:120529 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:120529 BioGRID:113170 UBE2D2    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    FAT10 activating enzyme activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    ubiquitin-like modifier-activating enzyme 6
    Names
    ubiquitin-like modifier-activating enzyme 6
    monocyte protein 4
    ubiquitin-activating enzyme 6
    UBA6, ubiquitin-activating enzyme E1
    ubiquitin-activating enzyme E1-like 2
    ubiquitin-activating enzyme E1-like protein 2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018227.5 → NP_060697.4  ubiquitin-like modifier-activating enzyme 6

      Status: VALIDATED

      Source sequence(s)
      AL596839, AL832015, AW451445, AY359880, BC126484, BM973988
      Consensus CDS
      CCDS3516.1
      UniProtKB/Swiss-Prot
      A0AVT1
      Related
      ENSP00000313454, OTTHUMP00000159634, ENST00000322244, OTTHUMT00000251429
      Conserved Domains (4) summary
      cd01490
      Location:462 – 777
      Blast Score: 1206
      Ube1_repeat2; Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
      cd01491
      Location:43 – 305
      Blast Score: 971
      Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
      TIGR01408
      Location:38 – 1048
      Blast Score: 4502
      Ube1; ubiquitin-activating enzyme E1
      cl09931
      Location:848 – 1005
      Blast Score: 505
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p5 Primary Assembly

      Range
      68481479..68566889, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      64394643..64480109, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC079880.6 None
    genomic AC096720.3 AAY40999.1
    genomic CH471057.1 EAX05549.1
      EAX05550.1
      EAX05551.1
      EAX05552.1
      EAX05553.1
    mRNA AB014773.1 BAB19785.1
    mRNA AK001670.1 BAA91824.1
    mRNA AK027020.1 None
    mRNA AK094164.1 BAG52833.1
    mRNA AK094969.1 BAC04463.1
    mRNA AK314371.1 BAG37000.1
    mRNA AL596839.1 None
    mRNA AL832015.2 CAD89908.1
    mRNA AL832458.2 CAD89959.1
    mRNA AW451445.1 None
    mRNA AY359880.1 AAQ63403.1
    mRNA BC031637.1 AAH31637.1
    mRNA BC126484.1 AAI26485.1
    mRNA BC126486.1 AAI26487.1
    mRNA BM973988.1 None
    mRNA EF623993.1 ABR25253.1
    other-genetic AM392673.1 CAL37551.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0AVT1.1 GenPept UniProtKB/Swiss-Prot:A0AVT1
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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