PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha [Homo sapiens (human)] - Gene

Summary

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Official Symbol: PPP2R3Aprovided by HGNC
Official Full Name: protein phosphatase 2, regulatory subunit B'', alphaprovided by HGNC
Primary source: HGNC:9307
See related: Ensembl:ENSG00000073711; HPRD:09225; MIM:604944; Vega:OTTHUMG00000159766
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PR72; PR130; PPP2R3
Summary: This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]

Genomic context

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Location :: 3q22.1

Sequence :: Chromosome: 3; NC_000003.11 (135684515..135866752)

See PPP2R3A in Epigenomics, MapViewer

Chromosome 3 - NC_000003.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

PP2A can be targeted in a calcium-regulated manner to Cdc6 via the PR70 subunit, where it plays a role in regulating protein phosphorylation and stability.
Title: Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunit.
The B''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A.
Title: The B''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A.
two Ca2+-binding EF-hand motifs in the B"/PR72 subunit of protein phosphatase 2A demonstrating the ability or calcium ions to interact with and regulate PP2A
Title: Identification and functional analysis of two Ca2+-binding EF-hand motifs in the B"/PR72 subunit of protein phosphatase 2A.
PR72 interacts physically and functionally with Naked cuticle. PR72, like Naked cuticle, acts as a negative regulator of the classical Wnt signaling cascade.
Title: PR72, a novel regulator of Wnt signaling required for Naked cuticle function.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

A genome-wide association study of the Protein C anticoagulant pathway.

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Tat, p14	tat	Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9	PubMed
	tat	An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression	PubMed
Vpr, p15	vpr	Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain	PubMed
	vpr	HIV-1 Vpr cell death causing peptide (amino acid residues 71-96) can activate the expression of PP2A when applied extracellularly to CD4+ T cells as well as cause the activation of PP2A from brain, liver, and adipose tissues	PubMed
	vpr	HIV-1 Vpr was found to upregulate PP2A in fission yeast	PubMed
	vpr	HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A	PubMed
nucleocapsid	gag	HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_871626.1			BIND	PubMed	A-alpha/C-alpha complex interacts with B"/PR72 subunit. This interaction was modeled on a demonstrated interaction between human A-alpha/C-alpha complex and B"/PR72 from an unspecified species.
Q06190	Q99996	AKAP9	HPRD	PubMed
Q06190	Q5T6C5	ATXN7L2	HPRD	PubMed
Q06190	Q99741	CDC6	HPRD	PubMed
Q06190	P09429	HMGB1	HPRD	PubMed
Q06190	Q06190	PPP2R3A	HPRD	PubMed
Q06190	P53041	PPP5C	HPRD	PubMed
Q06190	P28749	RBL1	HPRD	PubMed
BioGRID:111515	BioGRID:126028	ATXN7L2	BioGRID	PubMed	Two-hybrid
BioGRID:111515	BioGRID:107426	CDC6	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111515	BioGRID:108276	EGFR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111515	BioGRID:111507	PPP2CA	BioGRID	PubMed	Two-hybrid
BioGRID:111515	BioGRID:111516	PPP2R4	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111515	BioGRID:111868	RBL1	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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Dopaminergic synapse, organism-specific biosystem (from KEGG)
Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
Dopaminergic synapse, conserved biosystem (from KEGG)
Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
Glycogen Metabolism, organism-specific biosystem (from WikiPathways)
Glycogen Metabolism, organism-specific biosystemGlycogen is a very large, branched polymer of glucose residues. Within skeletal musle and liver glucose is stored as glycogen. In the liver, glycogen synthesis and degradation are regulated to mainta...
IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-6 Signaling Pathway, organism-specific biosystemInterleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M...
PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...
mRNA surveillance pathway, organism-specific biosystem (from KEGG)
mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
mRNA surveillance pathway, conserved biosystem (from KEGG)
mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...

General gene information

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Markers

D3S3343 (e-PCR)
- UniSTS:71973

STS-R74400 (e-PCR)
- UniSTS:60242

STS-N32916 (e-PCR)
- UniSTS:6248

RH17602 (e-PCR)
- UniSTS:8582

RH80956 (e-PCR)
- UniSTS:88743

RH78965 (e-PCR)
- UniSTS:23237

WI-14084 (e-PCR)
- UniSTS:62413

Genotypes

See PPP2R3A SNP Geneview Report
See PPP2R3A SNP Genotype Report
See PPP2R3A SNP Variation Viewer Report

Homology

Homologs of the PPP2R3A gene: The PPP2R3A gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and A.thaliana.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
calcium ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein phosphatase type 2A regulator activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
Wnt receptor signaling pathway involved in somitogenesis	IC Inferred by Curator more info	PubMed
eye photoreceptor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of canonical Wnt receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of canonical Wnt receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
protein dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
regulation of cell motility involved in somitogenic axis elongation	IGI Inferred from Genetic Interaction more info	PubMed
somatic muscle development	IGI Inferred from Genetic Interaction more info	PubMed
somite development	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
protein phosphatase type 2A complex	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with protein phosphatase type 2A complex	IDA Inferred from Direct Assay more info	PubMed
protein phosphatase type 2A complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

Names: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha; PP2A, subunit B, R3 isoform; PP2A subunit B isoforms B72/B130; serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B; protein phosphatase 2 (formerly 2A), regulatory subunit B'' (PR 72), alpha isoform and (PR 130), beta isoform

NP_001177376.1

EC 3.1.3.16

NP_002709.2

EC 3.1.3.16

NP_871626.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029234.1 RefSeqGene

Range

5001..187238

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001190447.1 → NP_001177376.1 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 3

Status: REVIEWED

Description

Transcript Variant: variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK298059, AL389975, DB223168, DB378665

Consensus CDS

CCDS54642.1

UniProtKB/Swiss-Prot

Q06190

Conserved Domains (1) summary

pfam13499
Location:172 – 265
Blast Score: 85

EF_hand_5; EF-hand domain pair
NM_002718.4 → NP_002709.2 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1), also known as isoform beta or isoform PR130.

Source sequence(s)

AK293012, AL389975, DB223168, DB378665

Consensus CDS

CCDS3087.1

UniProtKB/Swiss-Prot

Q06190

Related

ENSP00000264977, OTTHUMP00000216419, ENST00000264977, OTTHUMT00000357232

Conserved Domains (1) summary

pfam13499
Location:908 – 1001
Blast Score: 90

EF_hand_5; EF-hand domain pair
NM_181897.2 → NP_871626.1 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (2), also known as isoform alpha or isoform PR72, contains a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC072039, AK316258, AL389975, DB378665

Consensus CDS

CCDS3088.1

UniProtKB/Swiss-Prot

Q06190

Conserved Domains (1) summary

pfam13499
Location:287 – 380
Blast Score: 87

EF_hand_5; EF-hand domain pair

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000003.11 Reference GRCh37.p10 Primary Assembly

Range

135684515..135866752

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000135.1 Alternate HuRef

Range

133061996..133244183

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018914.1 Alternate CHM1_1.0

Range

135664448..135846701

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01059135.1 (6987..69039)	None
genomic	ABBA01059136.1	None
genomic	ABBA01059137.1	None
genomic	AC072039.19	None
genomic	AC092991.12 (2005..53074)	None
genomic	AMYH01013518.1 (41600..86365)	None
genomic	AMYH01013519.1	None
genomic	CH471052.2	EAW79122.1
		EAW79123.1
		EAW79124.1
		EAW79125.1
		EAW79126.1
mRNA	AK293012.1	BAF85701.1
mRNA	AK298059.1	BAG60353.1
mRNA	AK299544.1	BAG61490.1
mRNA	AK302163.1	BAG63530.1
mRNA	AK314243.1	BAG36910.1
mRNA	AK316258.1	BAH14629.1
mRNA	AL389975.1	CAB97532.1
mRNA	AL599266.1	None
mRNA	BC015034.1	AAH15034.1
mRNA	BC029409.1	AAH29409.1
mRNA	BC040158.1	None
mRNA	BC065531.1	AAH65531.1
mRNA	BE897340.1	None
mRNA	DB223168.1	None
mRNA	DB378665.1	None
mRNA	L07590.1	AAB02613.1
mRNA	L12146.1	AAB02614.1