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    PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha [ Homo sapiens (human) ]

    Gene ID: 5523, updated on 15-Jun-2013
    Official Symbol
    PPP2R3Aprovided by HGNC
    Official Full Name
    protein phosphatase 2, regulatory subunit B'', alphaprovided by HGNC
    Primary source
    HGNC:9307
    See related
    Ensembl:ENSG00000073711; HPRD:09225; MIM:604944; Vega:OTTHUMG00000159766
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PR72; PR130; PPP2R3
    Summary
    This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]
    Location :
    3q22.1
    Sequence :
    Chromosome: 3; NC_000003.11 (135684515..135866752)
    See PPP2R3A in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene kyphoscoliosis peptidase Neighboring gene EPH receptor B1 Neighboring gene downstream neighbor of SON pseudogene Neighboring gene ribosomal protein L31 pseudogene 23 Neighboring gene teratocarcinoma-derived growth factor 1 pseudogene 6 Neighboring gene male-specific lethal 2 homolog (Drosophila)

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Protein Gene Interaction Pubs
    Tat, p14 tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
    tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
    Vpr, p15 vpr Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain PubMed
    vpr HIV-1 Vpr cell death causing peptide (amino acid residues 71-96) can activate the expression of PP2A when applied extracellularly to CD4+ T cells as well as cause the activation of PP2A from brain, liver, and adipose tissues PubMed
    vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
    vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
    nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    NP_871626.1     BIND  PubMed A-alpha/C-alpha complex interacts with B"/PR72 subunit. This interaction was modeled on a demonstrated interaction between human A-alpha/C-alpha complex and B"/PR72 from an unspecified species. 
    Q06190 Q99996 AKAP9    HPRD  PubMed  
    Q06190 Q5T6C5 ATXN7L2    HPRD  PubMed  
    Q06190 Q99741 CDC6    HPRD  PubMed  
    Q06190 P09429 HMGB1    HPRD  PubMed  
    Q06190 Q06190 PPP2R3A    HPRD  PubMed  
    Q06190 P53041 PPP5C    HPRD  PubMed  
    Q06190 P28749 RBL1    HPRD  PubMed  
    BioGRID:111515 BioGRID:126028 ATXN7L2    BioGRID  PubMed Two-hybrid 
    BioGRID:111515 BioGRID:107426 CDC6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111515 BioGRID:108276 EGFR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111515 BioGRID:111507 PPP2CA    BioGRID  PubMed Two-hybrid 
    BioGRID:111515 BioGRID:111516 PPP2R4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111515 BioGRID:111868 RBL1    BioGRID  PubMed Affinity Capture-Western 
    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Glycogen Metabolism, organism-specific biosystem (from WikiPathways)
      Glycogen Metabolism, organism-specific biosystemGlycogen is a very large, branched polymer of glucose residues. Within skeletal musle and liver glucose is stored as glycogen. In the liver, glycogen synthesis and degradation are regulated to mainta...
    • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-6 Signaling Pathway, organism-specific biosystemInterleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...
    • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
      mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
    • mRNA surveillance pathway, conserved biosystem (from KEGG)
      mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase type 2A regulator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    protein phosphatase type 2A complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with protein phosphatase type 2A complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphatase type 2A complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Preferred Names
    serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
    Names
    serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
    PP2A, subunit B, R3 isoform
    PP2A subunit B isoforms B72/B130
    serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B
    protein phosphatase 2 (formerly 2A), regulatory subunit B'' (PR 72), alpha isoform and (PR 130), beta isoform
    NP_001177376.1
    NP_002709.2
    NP_871626.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029234.1 RefSeqGene

      Range
      5001..187238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001190447.1NP_001177376.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK298059, AL389975, DB223168, DB378665
      Consensus CDS
      CCDS54642.1
      UniProtKB/Swiss-Prot
      Q06190
      Conserved Domains (1) summary
      pfam13499
      Location:172265
      Blast Score: 85
      EF_hand_5; EF-hand domain pair
    2. NM_002718.4NP_002709.2  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1), also known as isoform beta or isoform PR130.
      Source sequence(s)
      AK293012, AL389975, DB223168, DB378665
      Consensus CDS
      CCDS3087.1
      UniProtKB/Swiss-Prot
      Q06190
      Related
      ENSP00000264977, OTTHUMP00000216419, ENST00000264977, OTTHUMT00000357232
      Conserved Domains (1) summary
      pfam13499
      Location:9081001
      Blast Score: 90
      EF_hand_5; EF-hand domain pair
    3. NM_181897.2NP_871626.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (2), also known as isoform alpha or isoform PR72, contains a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC072039, AK316258, AL389975, DB378665
      Consensus CDS
      CCDS3088.1
      UniProtKB/Swiss-Prot
      Q06190
      Conserved Domains (1) summary
      pfam13499
      Location:287380
      Blast Score: 87
      EF_hand_5; EF-hand domain pair

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p10 Primary Assembly

      Range
      135684515..135866752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      133061996..133244183
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018914.1 Alternate CHM1_1.0

      Range
      135664448..135846701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

      Supplemental Content

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