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    PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha [ Homo sapiens ]

    Gene ID: 5523, updated on 11-May-2012
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    Summary

    Official Symbol
    PPP2R3Aprovided by HGNC
    Official Full Name
    protein phosphatase 2, regulatory subunit B'', alphaprovided by HGNC
    Primary source
    HGNC:9307
    See related
    Ensembl:ENSG00000073711; HPRD:09225; MIM:604944; Vega:OTTHUMG00000159766
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PR72; PR130; PPP2R3
    Summary
    This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]
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    Genomic context

    Location :
    3q22.1
    Sequence :
    Chromosome: 3; NC_000003.11 (135684515..135866752)
    See PPP2R3A in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene kyphoscoliosis peptidase Neighboring gene EPH receptor B1 Neighboring gene downstream neighbor of SON pseudogene Neighboring gene ribosomal protein L31 pseudogene 23 Neighboring gene teratocarcinoma-derived growth factor 1 pseudogene 6 Neighboring gene male-specific lethal 2 homolog (Drosophila)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Diversity in genomic organisation, developmental regulation and distribution of the murine PR72/B" subunits of protein phosphatase 2A. Zwaenepoel K, et al. BMC Genomics, 2008 Aug 20. PMID 18715506.
    2. Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunit. Davis AJ, et al. J Biol Chem, 2008 Jun 6. PMID 18397887.
    3. The B''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A. Ahn JH, et al. Proc Natl Acad Sci U S A, 2007 Jun 5. PMID 17535922.
    4. Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins. Xing Y, et al. Cell, 2006 Oct 20. PMID 17055435.
    5. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Lim J, et al. Cell, 2006 May 19. PMID 16713569.

    See all (31) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. PP2A can be targeted in a calcium-regulated manner to Cdc6 via the PR70 subunit, where it plays a role in regulating protein phosphorylation and stability.
      Title: Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunit.
    2. The B''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A.
      Title: The B''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A.
    3. two Ca2+-binding EF-hand motifs in the B"/PR72 subunit of protein phosphatase 2A demonstrating the ability or calcium ions to interact with and regulate PP2A
      Title: Identification and functional analysis of two Ca2+-binding EF-hand motifs in the B"/PR72 subunit of protein phosphatase 2A.
    4. PR72 interacts physically and functionally with Naked cuticle. PR72, like Naked cuticle, acts as a negative regulator of the classical Wnt signaling cascade.
      Title: PR72, a novel regulator of Wnt signaling required for Naked cuticle function.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
    tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
    Vpr vpr HIV-1 Vpr was reported to mediate G2 arrest by forming a complex with PP2A through binding to the B55 regulatory subunit, thereby targeting the complex to the nucleus and enhancing cdc25 dephosphorylation, however the paper was subsequently retracted PubMed
    vpr HIV-1 Vpr cell death causing peptide (amino acid residues 71-96) can activate the expression of PP2A when applied extracellularly to CD4+ T cells as well as cause the activation of PP2A from brain, liver, and adipose tissues PubMed
    vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
    vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
    nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_871626.1     BIND  PubMed A-alpha/C-alpha complex interacts with B"/PR72 subunit. This interaction was modeled on a demonstrated interaction between human A-alpha/C-alpha complex and B"/PR72 from an unspecified species. 
    Q06190 Q99996 AKAP9    HPRD  PubMed  
    Q06190 Q5T6C5 ATXN7L2    HPRD  PubMed  
    Q06190 Q99741 CDC6    HPRD  PubMed  
    Q06190 P09429 HMGB1    HPRD  PubMed  
    Q06190 Q06190 PPP2R3A    HPRD  PubMed  
    Q06190 P53041 PPP5C    HPRD  PubMed  
    Q06190 P28749 RBL1    HPRD  PubMed  
    BioGRID:111515 BioGRID:107426 CDC6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111515 BioGRID:111507 PPP2CA    BioGRID  PubMed Two-hybrid 
    BioGRID:111515 BioGRID:111516 PPP2R4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111515 BioGRID:111868 RBL1    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Glycogen Metabolism, organism-specific biosystem (from WikiPathways)
      Glycogen Metabolism, organism-specific biosystemGlycogen is a very large, branched polymer of glucose residues. Within skeletal musle and liver glucose is stored as glycogen. In the liver, glycogen synthesis and degradation are regulated to mainta...
    • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-6 Signaling Pathway, organism-specific biosystemInterleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M...
    • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluri...
    • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
      mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
    • mRNA surveillance pathway, conserved biosystem (from KEGG)
      mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein phosphatase type 2A regulator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    protein dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    protein phosphatase type 2A complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein phosphatase type 2A complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
    Names
    serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
    PP2A, subunit B, R3 isoform
    PP2A subunit B isoforms B72/B130
    serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B
    protein phosphatase 2 (formerly 2A), regulatory subunit B'' (PR 72), alpha isoform and (PR 130), beta isoform
    NP_001177376.1
    NP_002709.2
    NP_871626.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029234.1 RefSeqGene

      Range
      5001..187238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001190447.1 → NP_001177376.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK298059, AL389975, DB223168, DB378665
      Consensus CDS
      CCDS54642.1
      UniProtKB/TrEMBL
      B4DNU1
      UniProtKB/Swiss-Prot
      Q06190
      Related
      ENSP00000419344, OTTHUMP00000216420, ENST00000490467, OTTHUMT00000357233
      Conserved Domains (1) summary
      pfam13499
      Location:172 – 265
      Blast Score: 85
      EF_hand_5; EF-hand domain pair

    2. NM_002718.4 → NP_002709.2  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1), also known as isoform beta or isoform PR130.
      Source sequence(s)
      AK293012, AL389975, DB223168, DB378665
      Consensus CDS
      CCDS3087.1
      UniProtKB/Swiss-Prot
      Q06190
      Related
      ENSP00000264977, OTTHUMP00000216419, ENST00000264977, OTTHUMT00000357232
      Conserved Domains (1) summary
      pfam13499
      Location:908 – 1001
      Blast Score: 90
      EF_hand_5; EF-hand domain pair

    3. NM_181897.2 → NP_871626.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (2), also known as isoform alpha or isoform PR72, contains a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC072039, AK316258, AL389975, DB378665
      Consensus CDS
      CCDS3088.1
      UniProtKB/Swiss-Prot
      Q06190
      Related
      ENSP00000334748, OTTHUMP00000216421, ENST00000334546, OTTHUMT00000357234
      Conserved Domains (1) summary
      pfam13499
      Location:287 – 380
      Blast Score: 87
      EF_hand_5; EF-hand domain pair

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p5 Primary Assembly

      Range
      135684515..135866752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      133061996..133244183
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC072039.19 None
    genomic AC092991.12 (2004..53073) None
    genomic CH471052.2 EAW79122.1
      EAW79123.1
      EAW79124.1
      EAW79125.1
      EAW79126.1
    mRNA AK293012.1 BAF85701.1
    mRNA AK298059.1 BAG60353.1
    mRNA AK299544.1 BAG61490.1
    mRNA AK302163.1 BAG63530.1
    mRNA AK314243.1 BAG36910.1
    mRNA AK316258.1 BAH14629.1
    mRNA AL389975.1 CAB97532.1
    mRNA AL599266.1 None
    mRNA BC015034.1 AAH15034.1
    mRNA BC029409.1 AAH29409.1
    mRNA BC040158.1 None
    mRNA BC065531.1 AAH65531.1
    mRNA BE897340.1 None
    mRNA DB223168.1 None
    mRNA DB378665.1 None
    mRNA L07590.1 AAB02613.1
    mRNA L12146.1 AAB02614.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06190.1 GenPept UniProtKB/Swiss-Prot:Q06190
    Q6P0N9 GenPept UniProtKB/TrEMBL:Q6P0N9
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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