Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha [ Homo sapiens (human) ]

Gene ID: 5523, updated on 12-Apr-2014
Official Symbol
PPP2R3Aprovided by HGNC
Official Full Name
protein phosphatase 2, regulatory subunit B'', alphaprovided by HGNC
Primary source
HGNC:9307
See related
Ensembl:ENSG00000073711; HPRD:09225; MIM:604944; Vega:OTTHUMG00000159766
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PR72; PR130; PPP2R3
Summary
This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]
Location :
3q22.1
Sequence :
Chromosome: 3; NC_000003.12 (135965673..136147910)
See PPP2R3A in Epigenomics, MapViewer

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 141 Neighboring gene EPH receptor B1 Neighboring gene uncharacterized LOC102724019 Neighboring gene downstream neighbor of SON pseudogene Neighboring gene teratocarcinoma-derived growth factor 1 pseudogene 6 Neighboring gene ribosomal protein L31 pseudogene 23 Neighboring gene male-specific lethal 2 homolog (Drosophila)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study of the Protein C anticoagulant pathway.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat, p14 tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
Vpr, p15 vpr Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain PubMed
vpr HIV-1 Vpr cell death causing peptide (amino acid residues 71-96) can activate the expression of PP2A when applied extracellularly to CD4+ T cells as well as cause the activation of PP2A from brain, liver, and adipose tissues PubMed
vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Dopaminergic synapse, organism-specific biosystem (from KEGG)
    Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • Dopaminergic synapse, conserved biosystem (from KEGG)
    Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • Glycogen Metabolism, organism-specific biosystem (from WikiPathways)
    Glycogen Metabolism, organism-specific biosystemGlycogen is a very large, branched polymer of glucose residues. Within skeletal musle and liver glucose is stored as glycogen. In the liver, glycogen synthesis and degradation are regulated to mainta...
  • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-6 Signaling Pathway, organism-specific biosystemInterleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...
  • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
    mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
  • mRNA surveillance pathway, conserved biosystem (from KEGG)
    mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase type 2A regulator activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway involved in somitogenesis IC
Inferred by Curator
more info
PubMed 
eye photoreceptor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of catalytic activity TAS
Traceable Author Statement
more info
PubMed 
regulation of cell motility involved in somitogenic axis elongation IGI
Inferred from Genetic Interaction
more info
PubMed 
somatic muscle development IGI
Inferred from Genetic Interaction
more info
PubMed 
somite development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
protein phosphatase type 2A complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with protein phosphatase type 2A complex IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase type 2A complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Preferred Names
serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
Names
serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
PP2A, subunit B, R3 isoform
PP2A subunit B isoforms B72/B130
serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B
protein phosphatase 2 (formerly 2A), regulatory subunit B'' (PR 72), alpha isoform and (PR 130), beta isoform
NP_001177376.1
NP_002709.2
NP_871626.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029234.1 RefSeqGene

    Range
    5001..187238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001190447.1NP_001177376.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 3

    See proteins identical to NP_001177376.1

    Status: REVIEWED

    Description
    Transcript Variant: variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK298059, AL389975, DB223168, DB378665
    Consensus CDS
    CCDS54642.1
    UniProtKB/Swiss-Prot
    Q06190
    Conserved Domains (1) summary
    pfam13499
    Location:172265
    Blast Score: 90
    EF-hand_7; EF-hand domain pair
  2. NM_002718.4NP_002709.2  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 1

    See proteins identical to NP_002709.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1), also known as isoform beta or isoform PR130.
    Source sequence(s)
    AK293012, AL389975, DB223168, DB378665
    Consensus CDS
    CCDS3087.1
    UniProtKB/Swiss-Prot
    Q06190
    Related
    ENSP00000264977, OTTHUMP00000216419, ENST00000264977, OTTHUMT00000357232
    Conserved Domains (1) summary
    pfam13499
    Location:9081001
    Blast Score: 96
    EF-hand_7; EF-hand domain pair
  3. NM_181897.2NP_871626.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 2

    See proteins identical to NP_871626.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (2), also known as isoform alpha or isoform PR72, contains a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC072039, AK316258, AL389975, DB378665
    Consensus CDS
    CCDS3088.1
    UniProtKB/Swiss-Prot
    Q06190
    Conserved Domains (1) summary
    pfam13499
    Location:287380
    Blast Score: 93
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000003.12

    Range
    135965673..136147910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713686.1XP_006713749.1  

    See proteins identical to XP_006713749.1

    Conserved Domains (1) summary
    pfam13499
    Location:9081001
    Blast Score: 96
    EF-hand_7; EF-hand domain pair

Alternate HuRef

Genomic

  1. AC_000135.1 Alternate HuRef

    Range
    133061996..133244183
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    135647730..135830019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Supplemental Content

Recent activity

Your browsing activity is temporarily unavailable.