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    PPP2R2C protein phosphatase 2, regulatory subunit B, gamma [ Homo sapiens ]

    Gene ID: 5522, updated on 19-May-2012
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    Summary

    Official Symbol
    PPP2R2Cprovided by HGNC
    Official Full Name
    protein phosphatase 2, regulatory subunit B, gammaprovided by HGNC
    Primary source
    HGNC:9306
    See related
    Ensembl:ENSG00000074211; HPRD:09345; MIM:605997; Vega:OTTHUMG00000090445
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PR52; PR55G; IMYPNO; IMYPNO1; B55-GAMMA; MGC33570
    Summary
    The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    4p16.1
    Sequence :
    Chromosome: 4; NC_000004.11 (6322305..6565327, complement)
    See PPP2R2C in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC285484 Neighboring gene Wolfram syndrome 1 (wolframin) Neighboring gene mannosidase, alpha, class 2B, member 2 Neighboring gene Morf4 family associated protein 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. PPP2R2C, a gene disrupted in autosomal dominant intellectual disability. Backx L, et al. Eur J Med Genet, 2010 Sep-Oct. PMID 20601260.
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    4. Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders. Kim S, et al. Mol Psychiatry, 2011 Apr. PMID 20308991.
    5. Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Rung J, et al. Nat Genet, 2009 Oct. PMID 19734900.

    See all (30) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. encoding a subunit of proteinphosphatase 2A with a unique expression pattern in brain and a role in synaptic plasticity
      Title: PPP2R2C, a gene disrupted in autosomal dominant intellectual disability.
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    3. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders.
    4. novel mechanism of c-SRC regulation whereby in response to stress c-SRC activity is regulated, at least in part, through loss of the interaction with its inhibitor, PR55gamma
      Title: A RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRC.
    5. specific PP2A complexes involved in human cell transformation
      Title: Identification of specific PP2A complexes involved in human cell transformation.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
    tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
    Vpr vpr HIV-1 Vpr was reported to mediate G2 arrest by forming a complex with PP2A through binding to the B55 regulatory subunit, thereby targeting the complex to the nucleus and enhancing cdc25 dephosphorylation, however the paper was subsequently retracted PubMed
    vpr HIV-1 Vpr cell death causing peptide (amino acid residues 71-96) can activate the expression of PP2A when applied extracellularly to CD4+ T cells as well as cause the activation of PP2A from brain, liver, and adipose tissues PubMed
    vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
    vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
    nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_065149.2 NP_002871.1 RAF1    BIND  PubMed RAF1 (c-Raf) interacts with an unspecified isoform of PPP2R2C (PP2A-C). 
    BioGRID:111514 BioGRID:106895 ARL2    BioGRID  PubMed Co-purification 
    BioGRID:111514 BioGRID:114908 BAG2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111514 BioGRID:115827 CCT2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111514 BioGRID:113054 CCT3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111514 BioGRID:115826 CCT4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111514 BioGRID:116603 CCT5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111514 BioGRID:107346 CCT6A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111514 BioGRID:115825 CCT7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111514 BioGRID:115933 CCT8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111514 BioGRID:120367 CDCA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111514 BioGRID:109561 HSPD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111514 BioGRID:111507 PPP2CA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111514 BioGRID:111510 PPP2R1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111514 BioGRID:111511 PPP2R1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111514 BioGRID:111513 PPP2R2B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111514 BioGRID:111269 SLC25A3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111514 BioGRID:112810 TCP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111514 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Glycogen Metabolism, organism-specific biosystem (from WikiPathways)
      Glycogen Metabolism, organism-specific biosystemGlycogen is a very large, branched polymer of glucose residues. Within skeletal musle and liver glucose is stored as glycogen. In the liver, glycogen synthesis and degradation are regulated to mainta...
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-6 Signaling Pathway, organism-specific biosystemInterleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluri...
    • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
      mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
    • mRNA surveillance pathway, conserved biosystem (from KEGG)
      mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein phosphatase type 2A regulator activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    signal transduction NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    protein phosphatase type 2A complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    protein phosphatase 2, regulatory subunit B, gamma
    Names
    protein phosphatase 2, regulatory subunit B, gamma
    PP2A, subunit B, B-gamma isoform
    PP2A, subunit B, R2-gamma isoform
    PP2A, subunit B, B55-gamma isoform
    PP2A, subunit B, PR55-gamma isoform
    protein phosphatase 2A1 B gamma subunit
    phosphoprotein phosphatase 2A BR gamma regulatory chain
    gamma isoform of regulatory subunit B55, protein phosphatase 2
    protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform
    serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
    NP_001193923.1
    NP_001193924.1
    NP_001193925.1
    NP_870991.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029233.1 RefSeqGene

      Range
      5001..248023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001206994.1 → NP_001193923.1  protein phosphatase 2, regulatory subunit B, gamma isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform b. Variants 3 and 4 both encode the same isoform (c).
      Source sequence(s)
      AC116317, AK296474, BC045682
      Consensus CDS
      CCDS56305.1
      Related
      ENSP00000423649, OTTHUMP00000217568, ENST00000506140, OTTHUMT00000359298
      Conserved Domains (2) summary
      COG5170
      Location:17 – 431
      Blast Score: 1070
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      cl02567
      Location:18 – 359
      Blast Score: 118
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001206995.1 → NP_001193924.1  protein phosphatase 2, regulatory subunit B, gamma isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform b. Variants 3 and 4 both encode the same isoform (c).
      Source sequence(s)
      AC116317, AK316003, BC045682, DC327075
      Consensus CDS
      CCDS56305.1
      Related
      ENSP00000425247, OTTHUMP00000217634, ENST00000507294, OTTHUMT00000359369
      Conserved Domains (2) summary
      COG5170
      Location:17 – 431
      Blast Score: 1070
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      cl02567
      Location:18 – 359
      Blast Score: 118
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_001206996.1 → NP_001193925.1  protein phosphatase 2, regulatory subunit B, gamma isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform b.
      Source sequence(s)
      AC116317, BC032954, BC045682
      Consensus CDS
      CCDS56304.1
      UniProtKB/Swiss-Prot
      Q9Y2T4
      Related
      ENSP00000422374, OTTHUMP00000217635, ENST00000515571, OTTHUMT00000359381
      Conserved Domains (2) summary
      COG5170
      Location:7 – 421
      Blast Score: 1065
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      cl02567
      Location:8 – 349
      Blast Score: 115
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. NM_181876.2 → NP_870991.1  protein phosphatase 2, regulatory subunit B, gamma isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (b).
      Source sequence(s)
      AC116317, AK093115
      Consensus CDS
      CCDS3388.1
      UniProtKB/Swiss-Prot
      Q9Y2T4
      Related
      ENSP00000335083, OTTHUMP00000115506, ENST00000335585, OTTHUMT00000206890
      Conserved Domains (2) summary
      COG5170
      Location:22 – 438
      Blast Score: 1076
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      cl02567
      Location:20 – 366
      Blast Score: 118
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p5 Primary Assembly

      Range
      6322305..6565327, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      6255749..6490033, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_020416.3: Suppressed sequence

      Description
      NM_020416.3: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC093323.3 None
    genomic AC114815.5 (1992..62606) None
    genomic AC116317.4 (82063..158942) None
    genomic AC122939.3 None
    genomic AJ328955.1 None
    genomic CH471131.2 EAW82393.1
      EAW82394.1
      EAW82395.1
    mRNA AB209183.1 BAD92420.1
    mRNA AF086924.1 AAG39636.1
    mRNA AF145027.1 AAP97279.1
    mRNA AK093115.1 BAG52658.1
    mRNA AK122849.1 None
    mRNA AK127386.1 None
    mRNA AK296474.1 BAH12367.1
    mRNA AK316003.1 BAH14374.1
    mRNA AW955803.1 None
    mRNA BC021735.2 None
    mRNA BC032954.2 AAH32954.1
    mRNA BC045682.1 None
    mRNA BM551976.1 None
    mRNA DC327075.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q59GC6 GenPept UniProtKB/TrEMBL:Q59GC6
    Q9Y2T4.4 GenPept UniProtKB/Swiss-Prot:Q9Y2T4
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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