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PPP2R2B protein phosphatase 2, regulatory subunit B, beta [ Homo sapiens (human) ]

Gene ID: 5521, updated on 12-Apr-2014
Official Symbol
PPP2R2Bprovided by HGNC
Official Full Name
protein phosphatase 2, regulatory subunit B, betaprovided by HGNC
Primary source
HGNC:9305
See related
Ensembl:ENSG00000156475; HPRD:05059; MIM:604325; Vega:OTTHUMG00000163381
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PR52B; SCA12; B55BETA; PR55BETA; PP2ABBETA; PP2APR55B; PR2ABBETA; PR55-BETA; PP2AB55BETA; PR2AB55BETA; PP2APR55BETA; PR2APR55BETA
Summary
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12. [provided by RefSeq, Jul 2008]
Location :
5q32
Sequence :
Chromosome: 5; NC_000005.10 (146589504..147081520, complement)
See PPP2R2B in Epigenomics, MapViewer

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 151 Neighboring gene RNA, 5S ribosomal pseudogene 196 Neighboring gene keratin 8 pseudogene 48 Neighboring gene PPP2R2B intronic transcript 1 (non-protein coding) Neighboring gene serine/threonine kinase 32A Neighboring gene dihydropyrimidinase-like 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Spinocerebellar ataxia 12
MedGen: C1858501 OMIM: 604326 GeneReviews: Spinocerebellar Ataxia Type 12
Compare labs

NHGRI GWAS Catalog

Description
Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.
NHGRI GWA Catalog
Genome-wide association study of alcohol dependence.
NHGRI GWA Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat, p14 tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
Vpr, p15 vpr Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain PubMed
vpr HIV-1 Vpr cell death causing peptide (amino acid residues 71-96) can activate the expression of PP2A when applied extracellularly to CD4+ T cells as well as cause the activation of PP2A from brain, liver, and adipose tissues PubMed
vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Dopaminergic synapse, organism-specific biosystem (from KEGG)
    Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • Dopaminergic synapse, conserved biosystem (from KEGG)
    Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • Glycogen Metabolism, organism-specific biosystem (from WikiPathways)
    Glycogen Metabolism, organism-specific biosystemGlycogen is a very large, branched polymer of glucose residues. Within skeletal musle and liver glucose is stored as glycogen. In the liver, glycogen synthesis and degradation are regulated to mainta...
  • Hepatitis C, organism-specific biosystem (from KEGG)
    Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Hepatitis C, conserved biosystem (from KEGG)
    Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-6 Signaling Pathway, organism-specific biosystemInterleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
  • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...
  • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
    mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
  • mRNA surveillance pathway, conserved biosystem (from KEGG)
    mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase type 2A regulator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of catalytic activity TAS
Traceable Author Statement
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphatase type 2A complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
Names
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
PP2A subunit B isoform R2-beta
PP2A subunit B isoform B55-beta
PP2A, subunit B, B-beta isoform
PP2A subunit B isoform PR55-beta
serine/threonine protein phosphatase 2A, neuronal isoform
protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, beta isoform
NP_001258828.1
NP_001258829.1
NP_001258877.1
NP_858060.2
NP_858061.2
NP_858062.1
NP_858063.1
NP_858064.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011570.1 RefSeqGene

    Range
    4951..496967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001271899.1NP_001258828.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform g

    See proteins identical to NP_001258828.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and the 5' coding region, compared to variant 3. The resulting isoform (g) is shorter and has a distinct N-terminus, compared to isoform e.
    Source sequence(s)
    AI621232, AK295347, BC031790, BX464346
    Consensus CDS
    CCDS64282.1
    UniProtKB/Swiss-Prot
    Q00005
    Related
    ENSP00000421396, OTTHUMP00000223707, ENST00000504198, OTTHUMT00000372949
    Conserved Domains (2) summary
    COG5170
    Location:14444
    Blast Score: 1243
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    cd00200
    Location:196440
    Blast Score: 90
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001271900.1NP_001258829.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform f

    See proteins identical to NP_001258829.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and the 5' coding region, compared to variant 3. The resulting isoform (f) is shorter and has a distinct N-terminus, compared to isoform e.
    Source sequence(s)
    AI621232, AK294659, BC031790, BX464346
    Consensus CDS
    CCDS64281.1
    UniProtKB/Swiss-Prot
    Q00005
    Conserved Domains (2) summary
    COG5170
    Location:80496
    Blast Score: 1245
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    cd00200
    Location:248492
    Blast Score: 89
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001271948.1NP_001258877.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform d

    See proteins identical to NP_001258877.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) has an additional segment and an additional exon in the 5' region, and initiates translation at an alternate downstream start codon, compared to variant 3. The resulting isoform (d) is shorter and has a distinct N-terminus, compared to isoform e. Variants 6 and 10 encode the same isoform d.
    Source sequence(s)
    AI621232, AK314810, BC031790, BP195204
    Consensus CDS
    CCDS43380.1
    UniProtKB/Swiss-Prot
    Q00005
    Conserved Domains (2) summary
    COG5170
    Location:13427
    Blast Score: 1213
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    cd00200
    Location:179423
    Blast Score: 93
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_181674.2NP_858060.2  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform a

    See proteins identical to NP_858060.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region, compared to variant 3. The resulting isoform (a) is shorter and has a distinct N-terminus, compared to isoform e.
    Source sequence(s)
    AI621232, BC031790, DA522334
    Consensus CDS
    CCDS4284.2
    UniProtKB/Swiss-Prot
    Q00005
    Related
    ENSP00000377936, OTTHUMP00000160097, ENST00000394414, OTTHUMT00000251892
    Conserved Domains (2) summary
    COG5170
    Location:88504
    Blast Score: 1251
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    cd00200
    Location:256500
    Blast Score: 90
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. NM_181675.3NP_858061.2  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (e).
    Source sequence(s)
    AI621232, AK056192, BC031790, DA533318
    UniProtKB/Swiss-Prot
    Q00005
    Related
    ENSP00000377933, OTTHUMP00000232497, ENST00000394411, OTTHUMT00000388939
    Conserved Domains (2) summary
    COG5170
    Location:128544
    Blast Score: 1265
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    cd00200
    Location:296540
    Blast Score: 93
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. NM_181676.2NP_858062.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform b

    See proteins identical to NP_858062.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and the 5' coding region, compared to variant 3. The resulting isoform (b) is shorter and has a distinct N-terminus, compared to isoform e.
    Source sequence(s)
    AI621232, BC031790, DA522334
    Consensus CDS
    CCDS4283.1
    UniProtKB/Swiss-Prot
    Q00005
    Related
    ENSP00000336591, OTTHUMP00000160099, ENST00000336640, OTTHUMT00000251894
    Conserved Domains (2) summary
    COG5170
    Location:25441
    Blast Score: 1230
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    cd00200
    Location:193437
    Blast Score: 92
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. NM_181677.2NP_858063.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform c

    See proteins identical to NP_858063.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and the 5' coding region, compared to variant 3. The resulting isoform (c) is shorter and has a distinct N-terminus, compared to isoform e.
    Source sequence(s)
    AI621232, BC031790, DA155307, DA365141
    UniProtKB/Swiss-Prot
    Q00005
    Conserved Domains (2) summary
    COG5170
    Location:2418
    Blast Score: 1216
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    cd00200
    Location:170414
    Blast Score: 92
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  8. NM_181678.2NP_858064.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform d

    See proteins identical to NP_858064.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and the 5' coding region, compared to variant 3. The resulting isoform (d) is shorter and has a distinct N-terminus, compared to isoform e. Variants 6 and 10 encode the same isoform d.
    Source sequence(s)
    AI621232, BC031790, BI669304, DA365141
    Consensus CDS
    CCDS43380.1
    UniProtKB/Swiss-Prot
    Q00005
    Related
    ENSP00000377932, ENST00000394410
    Conserved Domains (2) summary
    COG5170
    Location:13427
    Blast Score: 1213
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    cd00200
    Location:179423
    Blast Score: 93
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_073526.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) has an additional segment in the 5' region, compared to variant 3. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BP195204, M64930
  2. NR_073527.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) contains an alternate 5' exon, compared to variant 3. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI621232, AK056192, BC031790, BX647887, DA158596

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38 Primary Assembly

    Range
    146589504..147081520, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000137.1 Alternate HuRef

    Range
    141115900..141608335, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    145401722..145893553, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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