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    PPP2R2B protein phosphatase 2, regulatory subunit B, beta [ Homo sapiens ]

    Gene ID: 5521, updated on 24-May-2012
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    Summary

    Official Symbol
    PPP2R2Bprovided by HGNC
    Official Full Name
    protein phosphatase 2, regulatory subunit B, betaprovided by HGNC
    Primary source
    HGNC:9305
    See related
    Ensembl:ENSG00000156475; HPRD:05059; MIM:604325; Vega:OTTHUMG00000163381
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PR52B; SCA12; B55BETA; PR55BETA; PP2ABBETA; PP2APR55B; PR2ABBETA; PR55-BETA; PP2AB55BETA; PR2AB55BETA; PP2APR55BETA; PR2APR55BETA; FLJ95686; MGC24888
    Summary
    The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    5q32
    Sequence :
    Chromosome: 5; NC_000005.9 (145969067..146461033, complement)
    See PPP2R2B in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene transcription elongation regulator 1 Neighboring gene G protein-coupled receptor 151 Neighboring gene serine/threonine kinase 32A Neighboring gene dihydropyrimidinase-like 3

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. Spinocerebellar ataxia type 12. O'Hearn E, et al. Handb Clin Neurol, 2012. PMID 21827912.
    3. Induction of PP2A Bβ, a regulator of IL-2 deprivation-induced T-cell apoptosis, is deficient in systemic lupus erythematosus. Crispín JC, et al. Proc Natl Acad Sci U S A, 2011 Jul 26. PMID 21746932.
    4. Mitochondrial dysfunction and oxidative stress contribute to the pathogenesis of spinocerebellar ataxia type 12 (SCA12). Wang YC, et al. J Biol Chem, 2011 Jun 17. PMID 21471219.
    5. B55β-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer. Tan J, et al. Cancer Cell, 2010 Nov 16. PMID 21075311.

    See all (72) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. This study suggested that PPP2R2B CAG expansion mutation might lead increase induction of Spinocerebellar ataxia type 12.
      Title: Spinocerebellar ataxia type 12.
    2. defective production of PP2A Bbeta upon IL-2 deprivation results in apoptosis resistance and longer survival of autoreactive T cells, in a subset of SLE patients
      Title: Induction of PP2A Bβ, a regulator of IL-2 deprivation-induced T-cell apoptosis, is deficient in systemic lupus erythematosus.
    3. oxidative stress induced by mitochondrial dysfunction causes elevated expression of ppp2r2b and plays a causal role in SCA12; and reduction of ROS is a potential therapeutic intervention for this neuropathy
      Title: Mitochondrial dysfunction and oxidative stress contribute to the pathogenesis of spinocerebellar ataxia type 12 (SCA12).
    4. results indicate that the A variant of the rs319217 SNP of the PPP2R2B gene is a marker of better prognosis in breast cancer
      Title: A genetic variant in a PP2A regulatory subunit encoded by the PPP2R2B gene associates with altered breast cancer risk and recurrence.
    5. CAG repeat lengths in the PPP2R2B gene may be potential genetic markers for Alzheimer disease susceptibility in the Japanese population.
      Title: Association between CAG repeat length in the PPP2R2B gene and Alzheimer disease in the Japanese population.
    6. PPP2R2B, encoding the B55beta regulatory subunit of the PP2A complex, is epigenetically inactivated by DNA hypermethylation in colorectal cancer.
      Title: B55β-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer.
    7. Autosomal dominant cerebellar ataxia mapping to 5q31-q33.1 has no CAG repeat expansion or other mutations of the PPP2R2B gene.
      Title: Mapping of autosomal dominant cerebellar ataxia without the pathogenic PPP2R2B mutation to the locus for spinocerebellar ataxia 12.
    8. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    9. Quantitative methylation analysis identified ABCB1, FOXC1, PPP2R2B and PTEN as novel genes to be methylated in ductal carcinoma in situ.
      Title: Frequent aberrant DNA methylation of ABCB1, FOXC1, PPP2R2B and PTEN in ductal carcinoma in situ and early invasive breast cancer.
    10. The CAG repeat in SCA12 functions as a cis element to up-regulate PPP2R2B expression.
      Title: The CAG repeat in SCA12 functions as a cis element to up-regulate PPP2R2B expression.
    Submit: New GeneRIF Correction See all (33)
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    Phenotypes

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.

    Genome-wide association study of alcohol dependence.

    Spinocerebellar ataxia 12

    Summary from GeneReviews: Go to GeneReviews

    Disease Characteristics
    Spinocerebellar ataxia type 12 (SCA12) is characterized by onset of action tremor of the upper extremities in the fourth decade, slowly progressing to include ataxia and other cerebellar and cortical signs. Given the small number of individuals known to have SCA12, it is possible that other clinical manifestations have not yet been recognized.
    Diagnosis Testing
    PPP2R2B is the only gene in which mutation is known to cause SCA12. In the presence of clinical findings consistent with SCA12, an expansion of 51 or more CAG triplets within PPP2R2B is diagnostic; however, the boundary between the normal and mutant allele size remains to be determined. Molecular genetic testing is clinically available.
    Genetic Counseling
    SCA12 is inherited in an autosomal dominant manner. New mutations causing SCA12 have not been reported. Each child of an individual with SCA12 has a 50% chance of inheriting the mutation. Prenatal testing is possible but needs to be undertaken with caution as the positive predictive value of the CAG triplet repeat expansion in PPP2R2B is unknown.
    References
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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
    tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
    Vpr vpr HIV-1 Vpr was reported to mediate G2 arrest by forming a complex with PP2A through binding to the B55 regulatory subunit, thereby targeting the complex to the nucleus and enhancing cdc25 dephosphorylation, however the paper was subsequently retracted PubMed
    vpr HIV-1 Vpr cell death causing peptide (amino acid residues 71-96) can activate the expression of PP2A when applied extracellularly to CD4+ T cells as well as cause the activation of PP2A from brain, liver, and adipose tissues PubMed
    vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
    vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
    nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q00005 O96017 CHEK2    HPRD  PubMed  
    Q00005 P63000 RAC1    HPRD  PubMed  
    Q00005 P04637 TP53    HPRD  PubMed  
    BioGRID:111513 BioGRID:116429 ATXN2L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:114908 BAG2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:107282 CAPZB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:115827 CCT2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:113054 CCT3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:115826 CCT4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:116603 CCT5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:107346 CCT6A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:115825 CCT7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:115933 CCT8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:120367 CDCA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:116369 CHEK2    BioGRID  PubMed Two-hybrid 
    BioGRID:111513 BioGRID:114206 DYNLL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:125489 FAM122A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:114959 IER2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:119430 IER5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:110438 MLH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:110733 MYO9A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:111507 PPP2CA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:111508 PPP2CB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:111510 PPP2R1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:111511 PPP2R1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:111514 PPP2R2C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:111523 PPP4C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:111614 PRPH    BioGRID  PubMed Affinity Capture-MS 
    NP_002871.1 RAF1    BIND  PubMed RAF1 (c-Raf) interacts with an unspecified isoform of PPP2R2B (PP2A-B). 
    BioGRID:111513 BioGRID:112188 S100A9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:121121 SERTAD4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:128632 SKA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:131515 SKA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:128691 SKA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:117064 SKIV2L2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:116859 SOGA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:112810 TCP1    BioGRID  PubMed Affinity Capture-MS 
    NP_004603.1 TGFBR1    BIND  PubMed TGF-beta-RI interacts with an unspecified isoform of PPP2R2B. This interaction was modeled on a demonstrated interaction between human TGF-beta-RI and mouse PPP2R2B. 
    BioGRID:111513 BioGRID:115457 TRIM28    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:113135 TUFM    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:121203 ZC3HAV1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:120739 ZCCHC8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:113490 ZNF136    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111513 BioGRID:119066 ZNF295    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Glycogen Metabolism, organism-specific biosystem (from WikiPathways)
      Glycogen Metabolism, organism-specific biosystemGlycogen is a very large, branched polymer of glucose residues. Within skeletal musle and liver glucose is stored as glycogen. In the liver, glycogen synthesis and degradation are regulated to mainta...
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-6 Signaling Pathway, organism-specific biosystemInterleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluri...
    • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
      mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
    • mRNA surveillance pathway, conserved biosystem (from KEGG)
      mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    protein phosphatase type 2A regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell death IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein phosphatase type 2A complex IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
    Names
    serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
    PP2A subunit B isoform R2-beta
    PP2A subunit B isoform B55-beta
    PP2A, subunit B, B-beta isoform
    PP2A subunit B isoform PR55-beta
    serine/threonine protein phosphatase 2A, neuronal isoform
    protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform
    protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
    serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, beta isoform
    NP_001120853.1
    NP_004567.1
    NP_858060.1
    NP_858061.1
    NP_858062.1
    NP_858063.1
    NP_858064.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011570.1 RefSeqGene

      Range
      5001..496967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001127381.1 → NP_001120853.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, which includes a trinucleotide repeat region, compared to variant 1. Transcript variants 1, 2, 3 and 7 encode the same isoform (a).
      Source sequence(s)
      AI621232, BC031790, BX647887
      Consensus CDS
      CCDS4284.1
      UniProtKB/Swiss-Prot
      Q00005
      Related
      ENSP00000398779, ENST00000453001
      Conserved Domains (2) summary
      COG5170
      Location:22 – 438
      Blast Score: 1089
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      cl02567
      Location:25 – 371
      Blast Score: 128
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_004576.2 → NP_004567.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a. Transcript variants 1, 2, 3 and 7 encode the same isoform.
      Source sequence(s)
      M64930
      Consensus CDS
      CCDS4284.1
      UniProtKB/Swiss-Prot
      Q00005
      Related
      ENSP00000377935, OTTHUMP00000160098, ENST00000394413, OTTHUMT00000251893
      Conserved Domains (2) summary
      COG5170
      Location:22 – 438
      Blast Score: 1089
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      cl02567
      Location:25 – 371
      Blast Score: 128
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_181674.2 → NP_858060.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Transcript variants 1, 2, 3 and 7 encode the same isoform (a).
      Source sequence(s)
      AI621232, BC031790, DA522334
      Consensus CDS
      CCDS4284.1
      UniProtKB/Swiss-Prot
      Q00005
      Related
      ENSP00000349283, ENST00000356826
      Conserved Domains (2) summary
      COG5170
      Location:22 – 438
      Blast Score: 1089
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      cl02567
      Location:25 – 371
      Blast Score: 128
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. NM_181675.2 → NP_858061.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, which includes a trinucleotide repeat region, compared to variant 1. Transcript variants 1, 2, 3 and 7 encode the same isoform (a).
      Source sequence(s)
      AI621232, AK056192, BC031790, DA523686
      Consensus CDS
      CCDS4284.1
      UniProtKB/Swiss-Prot
      Q00005
      Related
      ENSP00000377933, OTTHUMP00000232497, ENST00000394411, OTTHUMT00000388939
      Conserved Domains (2) summary
      COG5170
      Location:22 – 438
      Blast Score: 1089
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      cl02567
      Location:25 – 371
      Blast Score: 128
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. NM_181676.2 → NP_858062.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and the 5' coding region, compared to variant 1. This results in a longer isoform (b) with a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AI621232, BC031790, DA522334
      Consensus CDS
      CCDS4283.1
      UniProtKB/Swiss-Prot
      Q00005
      Related
      ENSP00000336591, OTTHUMP00000160099, ENST00000336640, OTTHUMT00000251894
      Conserved Domains (2) summary
      COG5170
      Location:25 – 441
      Blast Score: 1101
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      cl02567
      Location:28 – 374
      Blast Score: 128
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. NM_181677.2 → NP_858063.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and the 5' coding region, compared to variant 1. This results in a shorter isoform (c) with a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AI621232, BC031790, DA155307, DA365141
      UniProtKB/Swiss-Prot
      Q00005
      Related
      ENSP00000421396, OTTHUMP00000223707, ENST00000504198, OTTHUMT00000372949
      Conserved Domains (2) summary
      COG5170
      Location:2 – 418
      Blast Score: 1087
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      cl02567
      Location:4 – 351
      Blast Score: 129
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    7. NM_181678.2 → NP_858064.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and the 5' coding region, compared to variant 1. This results in a shorter isoform (d) with a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AI621232, BC031790, BI669304, DA365141
      Consensus CDS
      CCDS43380.1
      UniProtKB/TrEMBL
      G3V149
      UniProtKB/Swiss-Prot
      Q00005
      Related
      ENSP00000377932, ENST00000394410
      Conserved Domains (2) summary
      COG5170
      Location:12 – 427
      Blast Score: 1085
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      cl02567
      Location:14 – 360
      Blast Score: 130
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      145969067..146461033, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      141115900..141608285, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC008728.7 (79409..165852) None
    genomic AC009186.7 (23714..49357) None
    genomic AC010251.3 (159203..164573) None
    genomic AC011357.5 (1043..138532) None
    genomic AC011386.6 None
    genomic AC091919.3 None
    genomic AC091924.4 (2835..50827) None
    genomic AF152102.1 AAF74024.1
    genomic CH471062.2 EAW61829.1
      EAW61830.1
      EAW61831.1
      EAW61832.1
      EAW61833.1
      EAW61834.1
      EAW61835.1
    mRNA AI621232.1 None
    mRNA AK056192.1 BAG51642.1
    mRNA AK289717.1 BAF82406.1
    mRNA AK294659.1 BAH11838.1
    mRNA AK295347.1 BAH12040.1
    mRNA AK314810.1 None
    mRNA AL540315.3 None
    mRNA AV726282.1 None
    mRNA BC031790.1 AAH31790.1
    mRNA BI669304.1 None
    mRNA BX647887.1 None
    mRNA DA155307.1 None
    mRNA DA365141.1 None
    mRNA DA522334.1 None
    mRNA DA523686.1 None
    mRNA M64930.1 AAA36491.1
      AAA36492.1
      AAA36493.1
    other-genetic DQ891785.2 ABM82711.1
    other-genetic DQ894969.2 ABM85895.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00005.1 GenPept UniProtKB/Swiss-Prot:Q00005
    Q9NS07 GenPept UniProtKB/TrEMBL:Q9NS07
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    Additional Links

    Additional Links

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