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PPP2R2A protein phosphatase 2, regulatory subunit B, alpha [ Homo sapiens (human) ]

Gene ID: 5520, updated on 12-Apr-2014
Official Symbol
PPP2R2Aprovided by HGNC
Official Full Name
protein phosphatase 2, regulatory subunit B, alphaprovided by HGNC
Primary source
HGNC:9304
See related
Ensembl:ENSG00000221914; HPRD:09223; MIM:604941; Vega:OTTHUMG00000163850
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B55A; PR52A; PR55A; B55ALPHA
Summary
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
Location :
8p21.2
Sequence :
Chromosome: 8; NC_000008.11 (26291491..26372680)
See PPP2R2A in Epigenomics, MapViewer

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene early B-cell factor 2 Neighboring gene uncharacterized LOC100507236 Neighboring gene matrix metallopeptidase 12 (macrophage elastase) pseudogene Neighboring gene uncharacterized LOC102723411 Neighboring gene SDA1 domain containing 1 pseudogene 1 Neighboring gene BCL2/adenovirus E1B 19kDa interacting protein 3-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of protein phosphatase 2, regulatory subunit B, alpha (PPP2R2A) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev, p19 rev HIV-1 Rev interacting protein, protein phosphatase 2, regulatory subunit B, alpha (PPP2R2A), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
Tat, p14 tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
Vpr, p15 vpr Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain PubMed
vpr HIV-1 Vpr cell death causing peptide (amino acid residues 71-96) can activate the expression of PP2A when applied extracellularly to CD4+ T cells as well as cause the activation of PP2A from brain, liver, and adipose tissues PubMed
vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase type 2A regulator activity TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine phosphatase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
RNA metabolic process TAS
Traceable Author Statement
more info
 
gene expression TAS
Traceable Author Statement
more info
 
mRNA metabolic process TAS
Traceable Author Statement
more info
 
mitotic cell cycle TAS
Traceable Author Statement
more info
 
mitotic nuclear envelope reassembly TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of catalytic activity TAS
Traceable Author Statement
more info
PubMed 
response to morphine IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
protein phosphatase type 2A complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Names
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR52), alpha isoform
serine/threonine protein phosphatase 2A, 55 KDA regulatory subunit B, alpha isoform
NP_001171062.1
NP_002708.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177591.1NP_001171062.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 2

    See proteins identical to NP_001171062.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' terminal exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AC022911, AI814790, AK303981, BC041071
    Consensus CDS
    CCDS55213.1
    UniProtKB/Swiss-Prot
    P63151
    Conserved Domains (2) summary
    COG5170
    Location:17452
    Blast Score: 1235
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    cd00200
    Location:39380
    Blast Score: 148
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_002717.3NP_002708.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 1

    See proteins identical to NP_002708.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AC022911, AI814790, AK314823, BC041071, DB451813
    Consensus CDS
    CCDS34867.1
    UniProtKB/Swiss-Prot
    P63151
    Related
    ENSP00000370113, OTTHUMP00000225159, ENST00000380737, OTTHUMT00000375954
    Conserved Domains (2) summary
    COG5170
    Location:7442
    Blast Score: 1234
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    cd00200
    Location:29370
    Blast Score: 148
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000008.11

    Range
    26291491..26372680
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273559.1XP_005273616.1  

    See proteins identical to XP_005273616.1

    Conserved Domains (2) summary
    COG5170
    Location:7441
    Blast Score: 1128
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    cl02567
    Location:27369
    Blast Score: 138
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_005273560.1XP_005273617.1  

    See proteins identical to XP_005273617.1

    Conserved Domains (1) summary
    cd00200
    Location:17211
    Blast Score: 116
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Alternate HuRef

Genomic

  1. AC_000140.1 Alternate HuRef

    Range
    24693626..24775115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    26350602..26431783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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