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    RPRD1A regulation of nuclear pre-mRNA domain containing 1A [ Homo sapiens ]

    Gene ID: 55197, updated on 11-May-2012
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    Summary

    Official Symbol
    RPRD1Aprovided by HGNC
    Official Full Name
    regulation of nuclear pre-mRNA domain containing 1Aprovided by HGNC
    Primary source
    HGNC:25560
    See related
    Ensembl:ENSG00000141425; HPRD:10134; MIM:610347; Vega:OTTHUMG00000132591
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P15RS; HsT3101; FLJ10656; MGC19513
    Summary
    P15RS is upregulated in cells overexpressing cyclin-dependent kinase inhibitor p15(INK4b) (CDKN2B; MIM 600431) and may have a role in cell cycle regulation (Liu et al., 2002 [PubMed 12470661]).[supplied by OMIM, Mar 2008]
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    Genomic context

    Location :
    18q12.2
    Sequence :
    Chromosome: 18; NC_000018.9 (33569791..33647373, complement)
    See RPRD1A in Epigenomics, MapViewer

    Chromosome 18 - NC_000018.9Genomic Context describing neighboring genes Neighboring gene microRNA 3929 Neighboring gene chromosome 18 open reading frame 21 Neighboring gene solute carrier family 39 (zinc transporter), member 6 Neighboring gene elongation protein 2 homolog (S. cerevisiae)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B. Ni Z, et al. Transcription, 2011 Sep-Oct. PMID 22231121.
    2. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Altun M, et al. Chem Biol, 2011 Nov 23. PMID 22118674.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. p15RS attenuates Wnt/{beta}-catenin signaling by disrupting {beta}-catenin·TCF4 Interaction. Wu Y, et al. J Biol Chem, 2010 Nov 5. PMID 20739273.
    5. System-wide changes to SUMO modifications in response to heat shock. Golebiowski F, et al. Sci Signal, 2009 May 26. PMID 19471022.

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. p15RS inhibits Wnt signaling by interrupting beta-catenin.TCF4 complex formation and that Wnt signaling initiates downstream gene expression by removing p15RS from promoters.
      Title: p15RS attenuates Wnt/{beta}-catenin signaling by disrupting {beta}-catenin·TCF4 Interaction.
    2. molecular cloning and characterization of P15RS, a novel P15(INK4b) related gene involved in G1/S progression
      Title: Identification and characterization of P15RS, a novel P15(INK4b) related gene on G1/S progression.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:120494 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120494 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    dephosphorylation of RNA polymerase II C-terminal domain IMP
    Inferred from Mutant Phenotype
    more info
    		  
    Component Evidence Code Pubs
    DNA-directed RNA polymerase II, holoenzyme IDA
    Inferred from Direct Assay
    more info
    		  
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    General protein information

    Preferred Names
    regulation of nuclear pre-mRNA domain-containing protein 1A
    Names
    regulation of nuclear pre-mRNA domain-containing protein 1A
    p15INK4B-related protein
    cyclin-dependent kinase 2B-inhibitor-related protein
    Cyclin-dependent kinase inhibitor 2B-related protein (p15INK4B-related protein)
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018170.3 → NP_060640.2  regulation of nuclear pre-mRNA domain-containing protein 1A

      Status: PROVISIONAL

      Source sequence(s)
      AF419845
      Consensus CDS
      CCDS11917.1
      UniProtKB/Swiss-Prot
      Q96P16
      Related
      ENSP00000381984, OTTHUMP00000163414, ENST00000399022, OTTHUMT00000255802
      Conserved Domains (1) summary
      cd03562
      Location:3 – 118
      Blast Score: 314
      CID; CID (CTD-Interacting Domain) domain family; CID is present in several RNA-processing factors such as Pcf11 and Nrd1. Pcf11 is a conserved and essential subunit of the yeast cleavage factor IA, which is required for polyadenylation-dependent 3'-RNA ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000018.9 Reference GRCh37.p5 Primary Assembly

      Range
      33569791..33647373, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000150.1 Alternate HuRef

      Range
      30428724..30506362, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC091060.10 (50185..127767) None
    genomic CH471088.1 EAX01365.1
      EAX01366.1
      EAX01367.1
      EAX01368.1
      EAX01369.1
      EAX01370.1
    mRNA AF419845.1 AAL15972.1
    mRNA AK001518.1 BAA91736.1
    mRNA AK292907.1 BAF85596.1
    mRNA AK314569.1 BAG37150.1
    mRNA BC000225.1 AAH00225.2
    mRNA BC010136.2 AAH10136.1
    other-genetic DQ892910.2 ABM83836.1
    other-genetic EU176720.1 ABW03521.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96P16.1 GenPept UniProtKB/Swiss-Prot:Q96P16
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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