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PPP2R1B protein phosphatase 2, regulatory subunit A, beta [ Homo sapiens (human) ]

Gene ID: 5519, updated on 7-Aug-2014
Official Symbol
PPP2R1Bprovided by HGNC
Official Full Name
protein phosphatase 2, regulatory subunit A, betaprovided by HGNC
Primary source
HGNC:9303
See related
Ensembl:ENSG00000137713; HPRD:04384; MIM:603113; Vega:OTTHUMG00000166741
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PR65B; PP2A-Abeta
Summary
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
See PPP2R1B in Epigenomics, MapViewer
Location:
11q23.2
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 11 NC_000011.10 (111725304..111769101, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (111597632..111637169, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene layilin Neighboring gene salt-inducible kinase 2 Neighboring gene uncharacterized LOC101928690 Neighboring gene uncharacterized LOC102724028 Neighboring gene ALG9, alpha-1,2-mannosyltransferase Neighboring gene guanine nucleotide binding protein (G protein), gamma 5 pseudogene 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of serine/threonine protein phosphatase 2A (65 kDa regulatory subunit A) in T-cell lines PubMed
Tat tat HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly in CD4+ T cells PubMed
tat HIV-1 Tat associates with the promoters of both PPP2R1B and PPP2R5E to increase PPP2R1B and PPP2R5E RNA and protein levels as well as PP2A activity in Jurkat T cells PubMed
tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
Vpr vpr Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain PubMed
vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

Go to the HIV-1, Human Protein Interaction Database

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    Cell Cycle, organism-specific biosystem
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  • Degradation of beta-catenin by the destruction complex, organism-specific biosystem (from REACTOME)
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  • Glucose metabolism, organism-specific biosystem (from REACTOME)
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  • Glycogen Metabolism, organism-specific biosystem (from WikiPathways)
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  • Hemostasis, organism-specific biosystem (from REACTOME)
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  • Hepatitis C, organism-specific biosystem (from KEGG)
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  • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
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  • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
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  • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
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  • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
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  • MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
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  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
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  • PP2A-mediated dephosphorylation of key metabolic factors, organism-specific biosystem (from REACTOME)
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  • RNF mutants show enhanced WNT signaling and proliferation, organism-specific biosystem (from REACTOME)
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  • Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
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  • S33 mutants of beta-catenin aren't phosphorylated, organism-specific biosystem (from REACTOME)
    S33 mutants of beta-catenin aren't phosphorylated, organism-specific biosystemS33 mutations of beta-catenin interfere with GSK3 phosphorylation and result in stabilization and nuclear localization of the protein and enhanced WNT signaling (Groen et al, 2008; Nhieu et al, 1999;...
  • S37 mutants of beta-catenin aren't phosphorylated, organism-specific biosystem (from REACTOME)
    S37 mutants of beta-catenin aren't phosphorylated, organism-specific biosystemS37 mutations of beta-catenin interfere with GSK3 phosphorylation and stabilize the protein, resulting in enhanced WNT pathway signaling (Nhieu et al, 1999; Clements et al, 2002; reviewed in Polakis,...
  • S45 mutants of beta-catenin aren't phosphorylated, organism-specific biosystem (from REACTOME)
    S45 mutants of beta-catenin aren't phosphorylated, organism-specific biosystemS45 mutants of beta-catenin have been identified in colorectal and hepatocellular carcinomas, soft tissue cancer and Wilms Tumors, among others (reviewed in Polakis, 2000). These mutations abolish th...
  • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
    Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Signaling by WNT in cancer, organism-specific biosystem (from REACTOME)
    Signaling by WNT in cancer, organism-specific biosystemThe WNT signaling pathway has been linked with cancer ever since the identification of the first WNT as a gene activated by integration of mouse mammary tumor virus proviral DNA in virally-induced br...
  • Signaling by Wnt, organism-specific biosystem (from REACTOME)
    Signaling by Wnt, organism-specific biosystemWNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Sai...
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
  • T41 mutants of beta-catenin aren't phosphorylated, organism-specific biosystem (from REACTOME)
    T41 mutants of beta-catenin aren't phosphorylated, organism-specific biosystemT41 mutations of beta-catenin interfere with GSK3 phosphorylation and result in stabilization and nuclear accumulation of the protein (Moreno-Bueno et al, 2002; Taniguchi et al, 2002; reviewed in Pol...
  • TCF dependent signaling in response to WNT, organism-specific biosystem (from REACTOME)
    TCF dependent signaling in response to WNT, organism-specific biosystem19 WNT ligands and 10 FZD receptors have been identified in human cells; interactions amongst these ligands and receptors vary in a developmental and tissue-specific manner and lead to activation of ...
  • TCF7L2 mutants don't bind CTBP, organism-specific biosystem (from REACTOME)
    TCF7L2 mutants don't bind CTBP, organism-specific biosystem~50% of colorectal cancers with microsatellite instability show frameshift mutations in TCF7L2 that result in the loss of the CTBP-binding region (Duval et al, 1999; Cuillliere-Dartigues et al, 2006)...
  • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
    TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • TGF-beta signaling pathway, conserved biosystem (from KEGG)
    TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem (from REACTOME)
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystemTRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.
  • TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystem (from REACTOME)
    TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystemTRIF(TICAM1) was shown to induce IRF3/7 and NF-?B activation and apoptosis through distinct intracellular signaling pathways [Han KJ et al 2004; Kaiser WJ and Offermann MK et al 2005]. TRIF consists...
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
  • Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemLittle is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may als...
  • Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemTLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products. It is quite possible that recognition of at le...
  • Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemToll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, macrophages, and appears to play a central role in mediating the antiviral and in...
  • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
  • Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemTLR5 is the receptor for flagellin, the protein that forms bacterial flagella. Unlike most other Pathogen-Associated Molecular Patterns (PAMPs), flagellin does not undergo any posttranslational modif...
  • Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemRNA can serve as a danger signal, both in its double-stranded form (that is associated with viral infection), as well as single-stranded RNA (ssRNA). Specifically, guanosine (G)- and uridine (U)-rich...
  • Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemCpG DNA is an unusual Pathogen-Associated Molecular Pattern (PAMP). Cytosine methylation exists in mammalian but not bacterial cells, and most (but not all) CpG in the mammalian genome is methylated....
  • Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemTLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial...
  • Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemTLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recog...
  • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
    Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
  • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...
  • XAV939 inhibits tankyrase, stabilizing AXIN, organism-specific biosystem (from REACTOME)
    XAV939 inhibits tankyrase, stabilizing AXIN, organism-specific biosystemXAV939 binds to the catalytic sites of tankyrase 1 and 2 and inhibits the ADP-ribosylation of AXIN1 and 2. Treatment of cells with XAV939 significantly increases the protein, but not the mRNA levels ...
  • deletions in the AMER1 gene destabilize the destruction complex, organism-specific biosystem (from REACTOME)
    deletions in the AMER1 gene destabilize the destruction complex, organism-specific biosystemGenomic deletions of the entire AMER1/WTX gene occur in about 12% of Wilms tumors, a pediatric kidney cancer. Nonsense and missense mutations have also been identified (Ruteshouser et al, 2008; Wege...
  • deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling, organism-specific biosystem (from REACTOME)
    deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling, organism-specific biosystemDeletions in the AXIN1 gene have been identified in 2 hepatocellular carcinoma cell lines. These deletions, which remove the N-terminal exons of the gene, compromise AXIN1 expression and result in ...
  • disassembly of the destruction complex and recruitment of AXIN to the membrane, organism-specific biosystem (from REACTOME)
    disassembly of the destruction complex and recruitment of AXIN to the membrane, organism-specific biosystemUpon stimulation with WNT ligand, AXIN and GSK3beta are recruited to the plasma membrane through interaction with DVL (Tamai et al, 2004; Mao et al, 2001; reviewed in He et al, 2004). Polymerization...
  • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
    mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
  • mRNA surveillance pathway, conserved biosystem (from KEGG)
    mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
  • misspliced GSK3beta mutants stabilize beta-catenin, organism-specific biosystem (from REACTOME)
    misspliced GSK3beta mutants stabilize beta-catenin, organism-specific biosystemGSK3beta is subject to in-frame missplicing in CML stem cells resulting in the production of mutant protein that lacks the AXIN and FRAT binding domains. Cells containing this mutant GSK3beta show e...
  • misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling, organism-specific biosystem (from REACTOME)
    misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling, organism-specific biosystemLRP5 is subject to an in-frame missplicing event in breast and parathyroid cancers that renders the protein insensitive to inhibition by the WNT antagonist DKK1. Expression of the mutant protein res...
  • phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex, organism-specific biosystem (from REACTOME)
    phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex, organism-specific biosystemMutations in exon 3 of the beta-catenin gene have been identified in a number of human cancers (Morin et al, 1997; Rubinfeld et al, 1997; reviewed in Polakis, 2000; Polakis, 2007). These mutations g...
  • truncated APC mutants destabilize the destruction complex, organism-specific biosystem (from REACTOME)
    truncated APC mutants destabilize the destruction complex, organism-specific biosystemAPC is a large and central component of the destruction complex, which limits signaling in the absence of WNT ligand by promoting the ubiquitin-mediated degradation of beta-catenin. APC interacts wi...
  • truncations of AMER1 destabilize the destruction complex, organism-specific biosystem (from REACTOME)
    truncations of AMER1 destabilize the destruction complex, organism-specific biosystemAMER1/WTX is a known component of the destruction complex and interacts directly with beta-catenin through the C-terminal half (Major et al, 2007). siRNA depletion of AMER1 in mammalian cells stabil...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC26454

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
membrane raft IDA
Inferred from Direct Assay
more info
 
Preferred Names
serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
Names
serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
PP2A, subunit A, R1-beta isoform
PP2A, subunit A, PR65-beta isoform
protein phosphatase 2, structural/regulatory subunit A, beta
protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform
NP_001171033.1
NP_001171034.1
NP_002707.3
NP_859050.1
NP_859051.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012117.1 

    Range
    5001..44538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001177562.1NP_001171033.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the coding region compared to variant 1. The resulting isoform (d) is shorter than isoform a.
    Source sequence(s)
    AF163473, AK294716, AP000925, AP001781, DC402587
    Consensus CDS
    CCDS53708.1
    UniProtKB/Swiss-Prot
    P30154
    Conserved Domains (3) summary
    pfam13513
    Location:191243
    Blast Score: 82
    HEAT_EZ; HEAT-like repeat
    pfam13646
    Location:217315
    Blast Score: 95
    HEAT_2; HEAT repeats
    cl09931
    Location:363421
    Blast Score: 86
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_001177563.1NP_001171034.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two in-frame exons in the 5' coding region compared to variant 1. The resulting isoform (e) is shorter than isoform a.
    Source sequence(s)
    AF163473, AK296455, AP000925, DC402587
    Consensus CDS
    CCDS53707.1
    UniProtKB/Swiss-Prot
    P30154
    Conserved Domains (3) summary
    COG1413
    Location:115347
    Blast Score: 115
    COG1413; FOG: HEAT repeat [Energy production and conversion]
    pfam13646
    Location:374469
    Blast Score: 82
    HEAT_2; HEAT repeats
    cl09931
    Location:281339
    Blast Score: 87
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. NM_002716.4NP_002707.3  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform a

    See proteins identical to NP_002707.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
    Source sequence(s)
    AF163473, AP000925, AP001781, BC027596
    Consensus CDS
    CCDS8349.1
    UniProtKB/Swiss-Prot
    P30154
    Related
    ENSP00000437193, OTTHUMP00000234119, ENST00000527614, OTTHUMT00000391298
    Conserved Domains (3) summary
    pfam13513
    Location:191243
    Blast Score: 82
    HEAT_EZ; HEAT-like repeat
    pfam13646
    Location:217315
    Blast Score: 95
    HEAT_2; HEAT repeats
    cl09931
    Location:408466
    Blast Score: 86
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. NM_181699.2NP_859050.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform b

    See proteins identical to NP_859050.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and the 3' coding region, compared to variant 1. The resulting isoform (b) contains a longer and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AF087438, AP001781, BC027596, DB527885
    Consensus CDS
    CCDS8348.1
    UniProtKB/Swiss-Prot
    P30154
    Related
    ENSP00000311344, OTTHUMP00000234117, ENST00000311129, OTTHUMT00000391296
    Conserved Domains (3) summary
    pfam13513
    Location:191243
    Blast Score: 85
    HEAT_EZ; HEAT-like repeat
    pfam13646
    Location:217315
    Blast Score: 99
    HEAT_2; HEAT repeats
    cl09931
    Location:408466
    Blast Score: 87
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  5. NM_181700.1NP_859051.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform c

    See proteins identical to NP_859051.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons in the 5' coding region and differs in the 3' UTR and the 3' coding region, compared to variant 1. The resulting isoform (c) contains a longer and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AF163473, AK301705, DB527885, DC402587
    Consensus CDS
    CCDS53706.1
    UniProtKB/Swiss-Prot
    P30154
    Related
    ENSP00000410671, OTTHUMP00000234118, ENST00000426998, OTTHUMT00000391297
    Conserved Domains (3) summary
    pfam13513
    Location:127179
    Blast Score: 85
    HEAT_EZ; HEAT-like repeat
    pfam13646
    Location:153251
    Blast Score: 99
    HEAT_2; HEAT repeats
    cl09931
    Location:344402
    Blast Score: 87
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000011.10 

    Range
    111725304..111769101
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718872.1XP_006718935.1  

    Conserved Domains (3) summary
    pfam13513
    Location:278330
    Blast Score: 86
    HEAT_EZ; HEAT-like repeat
    pfam13646
    Location:304402
    Blast Score: 103
    HEAT_2; HEAT repeats
    cl09931
    Location:495553
    Blast Score: 87
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. XM_006718867.1XP_006718930.1  

    See proteins identical to XP_006718930.1

    Conserved Domains (2) summary
    pfam13513
    Location:278330
    Blast Score: 85
    HEAT_EZ; HEAT-like repeat
    pfam13646
    Location:304402
    Blast Score: 101
    HEAT_2; HEAT repeats
  3. XM_006718869.1XP_006718932.1  

    Conserved Domains (3) summary
    pfam13513
    Location:278330
    Blast Score: 85
    HEAT_EZ; HEAT-like repeat
    pfam13646
    Location:304402
    Blast Score: 101
    HEAT_2; HEAT repeats
    cl09931
    Location:495553
    Blast Score: 87
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. XM_006718868.1XP_006718931.1  

    See proteins identical to XP_006718931.1

    Conserved Domains (2) summary
    pfam13513
    Location:278330
    Blast Score: 85
    HEAT_EZ; HEAT-like repeat
    pfam13646
    Location:304402
    Blast Score: 101
    HEAT_2; HEAT repeats
  5. XM_006718871.1XP_006718934.1  

    Conserved Domains (3) summary
    pfam13513
    Location:278330
    Blast Score: 84
    HEAT_EZ; HEAT-like repeat
    pfam13646
    Location:304402
    Blast Score: 98
    HEAT_2; HEAT repeats
    cl09931
    Location:450508
    Blast Score: 86
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  6. XM_006718870.1XP_006718933.1  

    Conserved Domains (3) summary
    pfam13513
    Location:278330
    Blast Score: 84
    HEAT_EZ; HEAT-like repeat
    pfam13646
    Location:304402
    Blast Score: 98
    HEAT_2; HEAT repeats
    cl09931
    Location:495553
    Blast Score: 87
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

Alternate HuRef

Genomic

  1. AC_000143.1 

    Range
    107521689..107561041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 

    Range
    111480686..111520221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)