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    RFWD3 ring finger and WD repeat domain 3 [ Homo sapiens ]

    Gene ID: 55159, updated on 11-May-2012
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    Summary

    Official Symbol
    RFWD3provided by HGNC
    Official Full Name
    ring finger and WD repeat domain 3provided by HGNC
    Primary source
    HGNC:25539
    See related
    Ensembl:ENSG00000168411; HPRD:07678; MIM:614151
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF201; FLJ10520
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    Genomic context

    Location :
    16q23.1
    Sequence :
    Chromosome: 16; NC_000016.9 (74655297..74700779, complement)
    See RFWD3 in Epigenomics, MapViewer

    Chromosome 16 - NC_000016.9Genomic Context describing neighboring genes Neighboring gene golgi glycoprotein 1 Neighboring gene ribosomal protein S10 pseudogene 23 Neighboring gene heat shock 10kDa protein 1 (chaperonin 10) pseudogene Neighboring gene thymopoietin pseudogene Neighboring gene mixed lineage kinase domain-like

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    2. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    5. RING finger and WD repeat domain 3 (RFWD3) associates with replication protein A (RPA) and facilitates RPA-mediated DNA damage response. Liu S, et al. J Biol Chem, 2011 Jun 24. PMID 21558276.

    See all (15) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. RFWD3 and RPA2 functionally interact and participate in replication checkpoint control
      Title: E3 ligase RFWD3 participates in replication checkpoint control.
    2. RFWD3 is recruited to sites of DNA damage and facilitates RPA-mediated DNA damage signaling and repair
      Title: RING finger and WD repeat domain 3 (RFWD3) associates with replication protein A (RPA) and facilitates RPA-mediated DNA damage response.
    3. Study identifies RFWD3 as a positive regulator of p53 stability when the G(1) cell cycle checkpoint is activated and provides an explanation for how p53 is protected from degradation in the presence of high levels of Mdm2.
      Title: RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:120460 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:120460 BioGRID:112037 RPA1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:120460 BioGRID:112038 RPA2    BioGRID  PubMed Affinity Capture-MS; Co-localization; Reconstituted Complex 
    BioGRID:120460 BioGRID:112039 RPA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120460 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:120460 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120460 BioGRID:113169 UBE2D1    BioGRID  PubMed Two-hybrid 
    BioGRID:120460 BioGRID:113170 UBE2D2    BioGRID  PubMed Two-hybrid 
    BioGRID:120460 BioGRID:113171 UBE2D3    BioGRID  PubMed Two-hybrid 
    BioGRID:120460 BioGRID:119641 UBE2D4    BioGRID  PubMed Two-hybrid 
    BioGRID:120460 BioGRID:113172 UBE2E1    BioGRID  PubMed Two-hybrid 
    BioGRID:120460 BioGRID:115740 UBE2E3    BioGRID  PubMed Two-hybrid 
    BioGRID:120460 BioGRID:113182 UBE2N    BioGRID  PubMed Two-hybrid 
    BioGRID:120460 BioGRID:120572 UBE2W    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the RFWD3 gene: The RFWD3 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    MDM2 binding IPI
    Inferred from Physical Interaction
    more info
    		  
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    p53 binding IPI
    Inferred from Physical Interaction
    more info
    		  
    ubiquitin-protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitotic cell cycle G1/S transition DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		  
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		  
    response to ionizing radiation IDA
    Inferred from Direct Assay
    more info
    		  
    Component Evidence Code Pubs
    PML body IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		  
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    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RFWD3
    Names
    E3 ubiquitin-protein ligase RFWD3
    RING finger protein 201
    RING finger and WD repeat domain-containing protein 3
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018124.3 → NP_060594.3  E3 ubiquitin-protein ligase RFWD3

      Status: VALIDATED

      Source sequence(s)
      BC002574, BC059371, BM467919, BP872110
      Consensus CDS
      CCDS32486.1
      UniProtKB/Swiss-Prot
      Q6PCD5
      Related
      ENSP00000354361, ENST00000361070
      Conserved Domains (3) summary
      cd00162
      Location:286 – 333
      Blast Score: 114
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam13923
      Location:283 – 332
      Blast Score: 115
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
      cl02567
      Location:489 – 774
      Blast Score: 135
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000016.9 Reference GRCh37.p5 Primary Assembly

      Range
      74655297..74700779, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000148.1 Alternate HuRef

      Range
      60404913..60450359, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC109599.4 (33523..79005) None
    genomic CH471114.2 EAW95680.1
      EAW95681.1
    mRNA AK001382.1 BAA91662.1
    mRNA AK022673.1 BAB14169.1
    mRNA AK291200.1 BAF83889.1
    mRNA AK296727.1 BAG59315.1
    mRNA AK315786.1 BAG38132.1
    mRNA BC002574.2 AAH02574.2
    mRNA BC059371.1 AAH59371.2
    mRNA BM467919.1 None
    mRNA BP872110.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PCD5.3 GenPept UniProtKB/Swiss-Prot:Q6PCD5
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

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