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    RBM23 RNA binding motif protein 23 [ Homo sapiens ]

    Gene ID: 55147, updated on 11-May-2012
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    Summary

    Official Symbol
    RBM23provided by HGNC
    Official Full Name
    RNA binding motif protein 23provided by HGNC
    Primary source
    HGNC:20155
    Locus tag
    PP239
    See related
    Ensembl:ENSG00000100461; HPRD:15227; Vega:OTTHUMG00000171467
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PP239; RNPC4; CAPERbeta; MGC4458; FLJ10482
    Summary
    This gene encodes a member of the U2AF-like family of RNA binding proteins. This protein interacts with some steroid nuclear receptors, localizes to the promoter of a steroid- responsive gene, and increases transcription of steroid-responsive transcriptional reporters in a hormone-dependent manner. It is also implicated in the steroid receptor-dependent regulation of alternative splicing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    14q11.2
    Sequence :
    Chromosome: 14; NC_000014.8 (23369854..23388396, complement)
    See RBM23 in Epigenomics, MapViewer

    Chromosome 14 - NC_000014.8Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor-related protein 10 Neighboring gene RAS (RAD and GEM)-like GTP binding 2 Neighboring gene PRMT5 antisense RNA 1 (non-protein coding) Neighboring gene protein arginine methyltransferase 5 Neighboring gene HAUS augmin-like complex, subunit 4 Neighboring gene microRNA 4707

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    2. The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. Rahman S, et al. Mol Cell Biol, 2011 Jul. PMID 21555454.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965.

    See all (17) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_060577.2 NP_000116.1 ESR1    BIND  PubMed RBM23 (CAPER-beta) interacts with ESR1(ER-alpha) 
    NP_060577.2 NP_000917.2 PGR    BIND  PubMed RBM23 (CAPER-beta) interacts with PR. 
    NP_060577.2 NT_086913.1 TFF1    BIND  PubMed RBM23 (CAPER-beta) interacts with the pS2 promoter. 
    Q86U06 P03372 ESR1    HPRD  PubMed  
    Q86U06 Q12789 GTF3C1    HPRD  PubMed  
    Q86U06 Q9P2H0 KIAA1377    HPRD  PubMed  
    Q86U06 Q9Y3C7 MED31    HPRD  PubMed  
    Q86U06 P06401 PGR    HPRD  PubMed  
    Q86U06 Q14181 POLA2    HPRD  PubMed  
    Q86U06 P21246 PTN    HPRD  PubMed  
    Q86U06 P27694 RPA1    HPRD  PubMed  
    Q86U06 P68366 TUBA4A    HPRD  PubMed  
    BioGRID:120450 BioGRID:109230 GTF3C1    BioGRID  PubMed Two-hybrid 
    BioGRID:120450 BioGRID:116817 JMJD6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120450 BioGRID:121617 KIAA1377    BioGRID  PubMed Two-hybrid 
    BioGRID:120450 BioGRID:119211 MED31    BioGRID  PubMed Two-hybrid 
    BioGRID:120450 BioGRID:117176 POLA2    BioGRID  PubMed Two-hybrid 
    BioGRID:120450 BioGRID:111731 PTN    BioGRID  PubMed Two-hybrid 
    BioGRID:120450 BioGRID:112037 RPA1    BioGRID  PubMed Two-hybrid 
    BioGRID:120450 BioGRID:115544 SRRM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120450 BioGRID:113128 TUBA4A    BioGRID  PubMed Two-hybrid 
    BioGRID:120450 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    probable RNA-binding protein 23
    Names
    probable RNA-binding protein 23
    splicing factor SF2
    RNA-binding motif protein 23
    RNA-binding region-containing protein 4
    RNA-binding region (RNP1, RRM) containing 4
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077351.1 → NP_001070819.1  probable RNA-binding protein 23 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC106012, BX161440, CK000110, CK003276
      Consensus CDS
      CCDS41921.1
      UniProtKB/Swiss-Prot
      Q86U06
      Related
      ENSP00000352956, OTTHUMP00000246102, ENST00000359890, OTTHUMT00000413545
      Conserved Domains (2) summary
      cd00590
      Location:264 – 336
      Blast Score: 248
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
      TIGR01622
      Location:147 – 438
      Blast Score: 858
      SF-CC1; splicing factor, CC1-like family

    2. NM_001077352.1 → NP_001070820.1  probable RNA-binding protein 23 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons, compared to variant 1. The resulting protein (isoform 3) is shorter than isoform 1.
      Source sequence(s)
      AK001344, AL132780, BC106012, CK000110, CK003276
      Consensus CDS
      CCDS41919.1
      UniProtKB/Swiss-Prot
      Q86U06
      Related
      ENSP00000339220, OTTHUMP00000246104, ENST00000346528, OTTHUMT00000413547
      Conserved Domains (2) summary
      cd00590
      Location:230 – 302
      Blast Score: 248
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
      TIGR01649
      Location:173 – 391
      Blast Score: 103
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    3. NM_018107.4 → NP_060577.3  probable RNA-binding protein 23 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AL135998, BC024208, BC106012, CK000110, CK003276
      Consensus CDS
      CCDS41920.1
      UniProtKB/Swiss-Prot
      Q86U06
      Related
      ENSP00000382806, OTTHUMP00000246103, ENST00000399922, OTTHUMT00000413546
      Conserved Domains (2) summary
      cd00590
      Location:248 – 320
      Blast Score: 248
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
      TIGR01622
      Location:131 – 422
      Blast Score: 858
      SF-CC1; splicing factor, CC1-like family

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000014.8 Reference GRCh37.p5 Primary Assembly

      Range
      23369854..23388396, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000146.1 Alternate HuRef

      Range
      3486930..3505430, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL132780.5 (8573..22960) None
    genomic AL135998.6 (407..4418) None
    genomic CH471078.2 EAW66222.1
      EAW66223.1
      EAW66224.1
      EAW66225.1
      EAW66226.1
      EAW66227.1
      EAW66228.1
      EAW66229.1
      EAW66230.1
    mRNA AF087905.1 AAP97203.1
    mRNA AF275678.1 AAG24388.1
    mRNA AK001344.1 BAA91638.1
    mRNA AK125593.1 BAG54220.1
    mRNA AK225792.1 None
    mRNA AK295448.1 BAH12071.1
    mRNA AK303668.1 BAH14010.1
    mRNA AK308055.1 None
    mRNA AK315620.1 BAG37988.1
    mRNA AL834198.1 CAD38887.1
    mRNA BC002566.2 AAH02566.1
    mRNA BC024208.2 AAH24208.1
    mRNA BC106012.1 None
    mRNA BX161440.1 CAD61910.1
    mRNA CK000110.1 None
    mRNA CK003276.1 None
    mRNA CR457257.1 CAG33538.1
    other-genetic HQ447933.1 ADQ32417.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IA98 GenPept UniProtKB/TrEMBL:Q6IA98
    Q86U06.1 GenPept UniProtKB/Swiss-Prot:Q86U06
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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