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    PPP1R10 protein phosphatase 1, regulatory subunit 10 [ Homo sapiens ]

    Gene ID: 5514, updated on 11-May-2012
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    Summary

    Official Symbol
    PPP1R10provided by HGNC
    Official Full Name
    protein phosphatase 1, regulatory subunit 10provided by HGNC
    Primary source
    HGNC:9284
    Locus tag
    DADB-129D20.4
    See related
    Ensembl:ENSG00000204569; HPRD:04797; MIM:603771; Vega:OTTHUMG00000031259
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FB19; CAT53; PNUTS; PP1R10
    Summary
    This gene encodes a protein with similarity to a rat protein that has an inhibitory effect on protein phosphatase-1 (PP1). The rat protein localizes to the nucleus and colocalizes with chromatin at distinct phases during mitosis. This gene lies within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    6p21.3
    Sequence :
    Chromosome: 6; NC_000006.11 (30568182..30585020, complement)
    See PPP1R10 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein-like 1 Neighboring gene proline rich 3 Neighboring gene ATP-binding cassette, sub-family F (GCN20), member 1 Neighboring gene microRNA 877 Neighboring gene mitochondrial ribosomal protein S18B Neighboring gene alpha tubulin acetyltransferase 1 Neighboring gene prothymosin, alpha pseudogene 1 (gene sequence 26)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. The protein phosphatase 1 regulator PNUTS is a new component of the DNA damage response. Landsverk HB, et al. EMBO Rep, 2010 Nov. PMID 20890310.
    5. Identification and characterization of a novel human PP1 phosphatase complex. Lee JH, et al. J Biol Chem, 2010 Aug 6. PMID 20516061.

    See all (29) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. PNUTS is identified as a new and integral component of the DNA damage response involved in DNA repair.
      Title: The protein phosphatase 1 regulator PNUTS is a new component of the DNA damage response.
    2. stimulation of PP1 activity via siRNA mediated knockdown of its interacting protein PNUTS (Phosphatase Nuclear Targeting Subunit) leads to Rb dephosphorylation and apoptosis in cancer cells
      Title: PNUTS knockdown potentiates the apoptotic effect of Roscovitine in breast and colon cancer cells.
    3. mammalian Wdr82 functions in a variety of cellular processes; PTW/PP1 phosphatase complex (PNUTS, Tox4, Wdr82, PP1) has a role in the regulation of chromatin structure during the transition from mitosis into interphase
      Title: Identification and characterization of a novel human PP1 phosphatase complex.
    4. the coordinated spatial and temporal regulation of LCP1 and PNUTS may be a novel mechanism to control the expression of genes that are critical for certain physiological and pathological processes.
      Title: Langerhans cell protein 1 (LCP1) binds to PNUTS in the nucleus: implications for this complex in transcriptional regulation.
    5. no evidence found of association between a CAT53 polymorphism and Alzheimer's Disease (AD), but found a significant negative association of the C282Y HFE mutation with AD
      Title: CAT53 and HFE alleles in Alzheimer's disease: a putative protective role of the C282Y HFE mutation.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
    7. reduced expression of PNUTS leads to activation of Rb-phosphatase and caspase-mediated apoptosis
      Title: Reduced expression of PNUTS leads to activation of Rb-phosphatase and caspase-mediated apoptosis.
    8. Findings suggest that PNUTS may play an important role in controlling cell death in response to cellular stresses such as hypoxia through the post-translational modification of p53 and MDM2.
      Title: Protein phosphatase 1 nuclear targeting subunit is a hypoxia inducible gene: its role in post-translational modification of p53 and MDM2.
    9. PNUTS has a role in protein kinase A-regulated targeting of PP1 to specific RNA-associated complexes in the nucleus
      Title: PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1- and RNA-binding domains and regulation by phosphorylation.
    10. PNUTS, encoded by CAT 53 on 6p21.3, may have a role in the progression of AD.
      Title: CAT 53: a protein phosphatase 1 nuclear targeting subunit encoded in the MHC Class I region strongly expressed in regions of the brain involved in memory, learning, and Alzheimer's disease.
    Submit: New GeneRIF Correction See all (11)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q96QC0 P62136 PPP1CA    HPRD  PubMed  
    BioGRID:111506 BioGRID:216776 Cep72    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111506 BioGRID:109540 HSPA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111506 BioGRID:111493 PPP1CA    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111506 BioGRID:111494 PPP1CB    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111506 BioGRID:111495 PPP1CC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111506 BioGRID:111506 PPP1R10    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111506 BioGRID:206343 Ppp1r10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111506 BioGRID:113188 SUMO1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111506 BioGRID:115209 TOX4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111506 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111506 BioGRID:123245 WDR82    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein phosphatase 1 binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    protein import into nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    PTW/PP1 phosphatase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    nuclear chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 1 regulatory subunit 10
    Names
    serine/threonine-protein phosphatase 1 regulatory subunit 10
    p99
    HLA-C associated transcript 53
    PP1-binding protein of 114 kDa
    phosphatase nuclear targeting subunit
    phosphatase 1 nuclear targeting subunit
    MHC class I region proline-rich protein CAT53
    protein phosphatase 1, regulatory (inhibitor) subunit 10
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002714.2 → NP_002705.2  serine/threonine-protein phosphatase 1 regulatory subunit 10

      Status: REVIEWED

      Source sequence(s)
      BC005267, Y13247
      Consensus CDS
      CCDS4681.1
      UniProtKB/TrEMBL
      Q2L6I0
      UniProtKB/TrEMBL
      Q58F28
      UniProtKB/Swiss-Prot
      Q96QC0
      Related
      ENSP00000365694, OTTHUMP00000029381, ENST00000376511, OTTHUMT00000076556
      Conserved Domains (2) summary
      cl11592
      Location:909 – 932
      Blast Score: 100
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      cl00146
      Location:105 – 146
      Blast Score: 114
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      30568182..30585020, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.2 Reference GRCh37.p5 ALT_REF_LOCI_2

      Range
      2080235..2097073, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.1 Reference GRCh37.p5 ALT_REF_LOCI_3

      Range
      1861820..1878658, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.1 Reference GRCh37.p5 ALT_REF_LOCI_4

      Range
      1916254..1933092, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.1 Reference GRCh37.p5 ALT_REF_LOCI_5

      Range
      1950037..1966876, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.1 Reference GRCh37.p5 ALT_REF_LOCI_6

      Range
      1861090..1877927, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.1 Reference GRCh37.p5 ALT_REF_LOCI_7

      Range
      1900461..1917299, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      30368350..30385188, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AB088097.1 BAC54929.1
    genomic AB103603.1 BAF31264.1
    genomic AB202094.1 BAE78613.1
    genomic AL662800.4 (100578..117416) None
    genomic AL662825.5 (57754..74592) None
    genomic BA000025.2 BAB63324.1
    genomic BX119957.13 CAM25909.1
    genomic BX248507.3 CAI18567.1
    genomic BX908728.7 CAQ07410.1
    genomic CH471081.1 EAX03303.1
    genomic CR753328.11 CAP58451.1
    genomic CR759778.8 CAQ09403.1
    mRNA AJ544537.1 CAD67521.1
    mRNA AK307406.1 None
    mRNA BC005267.2 AAH05267.1
    mRNA BC136294.1 AAI36295.1
    mRNA BC150310.1 None
    mRNA Y13247.1 CAA73697.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2L6I0 GenPept UniProtKB/TrEMBL:Q2L6I0
    Q58F28 GenPept UniProtKB/TrEMBL:Q58F28
    Q96QC0.1 GenPept UniProtKB/Swiss-Prot:Q96QC0
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
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