CEP192 centrosomal protein 192kDa [Homo sapiens] - Gene

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Summary

Official Symbol: CEP192provided by HGNC
Official Full Name: centrosomal protein 192kDaprovided by HGNC
Primary source: HGNC:25515
Locus tag: PP8407
See related: Ensembl:ENSG00000101639; HPRD:10855; Vega:OTTHUMG00000160693
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PPP1R62

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Genomic context

Location :: 18p11.21

Sequence :: Chromosome: 18; NC_000018.9 (12991361..13125052)

See CEP192 in Epigenomics, MapViewer

Chromosome 18 - NC_000018.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cep192-mediated mechanism maximizes AurA activity at centrosomes and appears essential for the function of these organelles as primary microtubule -organizing centers.
Title: Centrosomal protein of 192 kDa (Cep192) promotes centrosome-driven spindle assembly by engaging in organelle-specific Aurora A activation.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
major regulator of pericentriolar material recruitment, centrosome maturation, and centriole duplication in mammalian cells
Title: The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis.
Cep192 stimulates the formation of the scaffolding upon which gamma-tubulin ring complexes and other proteins involved in microtubule nucleation and spindle assembly become functional during mitosis.
Title: Human Cep192 is required for mitotic centrosome and spindle assembly.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Centrosomal protein 192 kDa	P04278	SHBG	HPRD	PubMed
BioGRID:120432	BioGRID:112666	AURKA	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120432	BioGRID:107920	CYLD	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120432	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
phosphatase binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
G2/M transition of mitotic cell cycle	TAS Traceable Author Statement more info
centrosome duplication	IMP Inferred from Mutant Phenotype more info	PubMed
mitotic cell cycle	TAS Traceable Author Statement more info
negative regulation of phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
centriole	IEA Inferred from Electronic Annotation more info
centrosome	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoskeleton	IEA Inferred from Electronic Annotation more info
cytosol	TAS Traceable Author Statement more info

General protein information

Preferred Names: centrosomal protein of 192 kDa

Names: centrosomal protein of 192 kDa; protein phosphatase 1, regulatory subunit 62

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032142.3 → NP_115518.3 centrosomal protein of 192 kDa

Status: VALIDATED

Source sequence(s)

AA761229, AB046789, AK096548, AL833494, BC144481, BX648232, DB079620

Consensus CDS

CCDS32792.2

UniProtKB/TrEMBL

B7ZMF0

UniProtKB/TrEMBL

E9PF99

UniProtKB/TrEMBL

Q9HCK3

Related

ENSP00000427550, OTTHUMP00000218756, ENST00000506447, OTTHUMT00000361790

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000018.9 Reference GRCh37.p5 Primary Assembly

Range

12991361..13125052

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000150.1 Alternate HuRef

Range

12945186..13078823

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_018069.2: Suppressed sequence

Description

NM_018069.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AP001357.5 (51249..140729)	None
genomic	AP002449.4 (156927..183999)	None
mRNA	AA761229.1	None
mRNA	AB046789.1	BAB13395.1
mRNA	AF318363.1	AAL55870.1
mRNA	AK001214.1	BAA91559.1
mRNA	AK074074.1	BAB84900.1
mRNA	AK094448.1	BAG52866.1
mRNA	AK096548.1	None
mRNA	AL136818.1	CAB66752.1
mRNA	AL833494.2	None
mRNA	BC144480.1	AAI44481.1
mRNA	BC144481.1	AAI44482.1
mRNA	BX648232.1	None
mRNA	BX649151.1	None
mRNA	DB079620.1	None