Format

Send to:

Choose Destination

MAGOHB mago homolog B, exon junction complex core component [ Homo sapiens (human) ]

Gene ID: 55110, updated on 26-May-2016
Official Symbol
MAGOHBprovided by HGNC
Official Full Name
mago homolog B, exon junction complex core componentprovided by HGNC
Primary source
HGNC:HGNC:25504
See related
Ensembl:ENSG00000111196 HPRD:08544; Vega:OTTHUMG00000168407
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MGN2; mago; magoh
Orthologs
Location:
12p13.2
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (10603765..10613609, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10756364..10766208, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101060038 Neighboring gene uncharacterized LOC105376675 Neighboring gene killer cell lectin like receptor A1, pseudogene Neighboring gene serine/threonine/tyrosine kinase 1 Neighboring gene Y-box binding protein 3 Neighboring gene uncharacterized LOC105369660

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat downregulates the abundance of mago-nashi homolog B (MAGOHB) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

  • Exon junction complex (EJC), organism-specific biosystem (from KEGG)
    Exon junction complex (EJC), organism-specific biosystemStructural complex; Genetic information processing; RNA processing
  • Exon junction complex (EJC), conserved biosystem (from KEGG)
    Exon junction complex (EJC), conserved biosystemStructural complex; Genetic information processing; RNA processing
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • Spliceosome, organism-specific biosystem (from KEGG)
    Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, conserved biosystem (from KEGG)
    Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
    mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
  • mRNA surveillance pathway, conserved biosystem (from KEGG)
    mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ10292

Gene Ontology Provided by GOA

Function Evidence Code Pubs
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
exon-exon junction complex IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein mago nashi homolog 2
Names
mago-nashi homolog B

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300739.2NP_001287668.1  protein mago nashi homolog 2 isoform 2

    See identical proteins and their annotated locations for NP_001287668.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' structure and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC021049, BG497574, BU933036, DB340467
    Consensus CDS
    CCDS76532.1
    UniProtKB/TrEMBL
    F5H6P7
    Conserved Domains (1) summary
    cl03715
    Location:1102
    Mago_nashi; Mago nashi proteins, integral members of the exon junction complex
  2. NM_001319985.1NP_001306914.1  protein mago nashi homolog 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC021049, AF165518, BF667243, BG533740, CD357202
    UniProtKB/Swiss-Prot
    Q96A72
    UniProtKB/TrEMBL
    F5H6P7
    Conserved Domains (1) summary
    cl03715
    Location:1102
    Mago_nashi; Mago nashi proteins, integral members of the exon junction complex
  3. NM_018048.4NP_060518.1  protein mago nashi homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_060518.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC021049, AF165518, BG533740, CD357202
    Consensus CDS
    CCDS8628.1
    UniProtKB/Swiss-Prot
    Q96A72
    UniProtKB/TrEMBL
    A0A023T6R1
    Related
    ENSP00000319240, OTTHUMP00000238722, ENST00000320756, OTTHUMT00000399616
    Conserved Domains (1) summary
    cd11295
    Location:6148
    Mago_nashi; Mago nashi proteins, integral members of the exon junction complex

RNA

  1. NR_135120.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC021049, BC000928, BG533740, CD357202
  2. NR_135121.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' region and contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC021049, BC000928, BG533740, BG539870

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    10603765..10613609 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253402.1XP_005253459.1  

    See identical proteins and their annotated locations for XP_005253459.1

    UniProtKB/TrEMBL
    F5H6P7
    Conserved Domains (1) summary
    cl03715
    Location:1102
    Mago_nashi; Mago nashi proteins, integral members of the exon junction complex
  2. XM_011520718.1XP_011519020.1  

    Related
    ENSP00000437462, OTTHUMP00000238720, ENST00000539554, OTTHUMT00000399613
    Conserved Domains (1) summary
    cl03715
    Location:1102
    Mago_nashi; Mago nashi proteins, integral members of the exon junction complex

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    10725748..10735584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)