My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 [ Homo sapiens ]

    Gene ID: 55103, updated on 11-May-2012
    Help top of page

    Summary

    Official Symbol
    RALGPS2provided by HGNC
    Official Full Name
    Ral GEF with PH domain and SH3 binding motif 2provided by HGNC
    Primary source
    HGNC:30279
    Locus tag
    RP4-595C2.1
    See related
    Ensembl:ENSG00000116191; HPRD:15206; Vega:OTTHUMG00000035076
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    dJ595C2.1; FLJ10244; FLJ25604; KIAA0351
    Help top of page

    Genomic context

    Location :
    1q25.2
    Sequence :
    Chromosome: 1; NC_000001.10 (178694300..178889238)
    See RALGPS2 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene chromosome 1 open reading frame 220 Neighboring gene microRNA 4424 Neighboring gene uncharacterized LOC646976 Neighboring gene protein tyrosine phosphatase, non-receptor type 2 pseudogene 1 Neighboring gene angiopoietin-like 1 Neighboring gene ribosomal protein S26 pseudogene 16 Neighboring gene family with sequence similarity 20, member B Neighboring gene torsin family 3, member A

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    3. Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing RM, et al. Mol Syst Biol, 2007. PMID 17353931.
    4. Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. Benzinger A, et al. Mol Cell Proteomics, 2005 Jun. PMID 15778465.
    5. Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Jin J, et al. Curr Biol, 2004 Aug 24. PMID 15324660.

    See all (10) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Ral GEF with PH domain and SH3 binding motif 2 P31946 YWHAB    HPRD  PubMed  
    Ral GEF with PH domain and SH3 binding motif 2 P61981 YWHAG    HPRD  PubMed  
    Ral GEF with PH domain and SH3 binding motif 2 P63104 YWHAZ    HPRD  PubMed  
    BioGRID:120413 BioGRID:109072 SFN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120413 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120413 BioGRID:113361 YWHAB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120413 BioGRID:113364 YWHAG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120413 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-MS 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    ras-specific guanine nucleotide-releasing factor RalGPS2
    Names
    ras-specific guanine nucleotide-releasing factor RalGPS2
    ralA exchange factor RalGPS2
    Ral-A exchange factor RalGPS2
    ral GEF with PH domain and SH3-binding motif 2
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152663.3 → NP_689876.2  ras-specific guanine nucleotide-releasing factor RalGPS2

      Status: VALIDATED

      Source sequence(s)
      AL355520, BC047391
      Consensus CDS
      CCDS1325.1
      UniProtKB/Swiss-Prot
      Q86X27
      Related
      ENSP00000356607, OTTHUMP00000033050, ENST00000367635, OTTHUMT00000084926
      Conserved Domains (2) summary
      cd00155
      Location:45 – 283
      Blast Score: 483
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00821
      Location:460 – 567
      Blast Score: 119
      PH; Pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      178694300..178889238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      149922359..150116845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_018037.1: Suppressed sequence

      Description
      NM_018037.1: This RefSeq was permanently suppressed because its 3' end is primarily intronic sequence.
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL162255.17 CAH71096.1
      CAH71097.1
      CAH71098.1
    genomic AL355520.8 CAI21918.1
      CAI21919.1
      CAI21920.1
      CAI21922.1
      CAI21923.1
      CAI21924.1
      CAI21925.1
    genomic AL449106.15 (68823..74670) None
    genomic CH471067.1 EAW91027.1
      EAW91028.1
      EAW91029.1
      EAW91030.1
    genomic JA738811.1 CCF77058.1
    mRNA AK001106.1 BAA91506.1
    mRNA AK098470.1 BAC05311.1
    mRNA AK301753.1 BAH13547.1
    mRNA BC045691.1 None
    mRNA BC047391.1 AAH47391.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86X27.1 GenPept UniProtKB/Swiss-Prot:Q86X27
    Q8N7G9 GenPept UniProtKB/TrEMBL:Q8N7G9
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...