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PPP1R7 protein phosphatase 1 regulatory subunit 7 [ Homo sapiens (human) ]

Gene ID: 5510, updated on 26-May-2016
Official Symbol
PPP1R7provided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 7provided by HGNC
Primary source
HGNC:HGNC:9295
See related
Ensembl:ENSG00000115685 HPRD:04192; MIM:602877; Vega:OTTHUMG00000133390
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDS22
Summary
This gene encodes a protein subunit that regulates the activity of the serine/threonine phosphatase, protein phosphatase-1. The encoded protein is required for completion of the mitotic cycle and for targeting protein phosphatase-1 to mitotic kinetochores. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Orthologs
Location:
2q37.3
Exon count:
12
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (241149573..241183650)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (242089012..242122439)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene sushi, nidogen and EGF like domains 1 Neighboring gene mitochondrial transcription termination factor 4 Neighboring gene uncharacterized LOC105373972 Neighboring gene PAS domain containing serine/threonine kinase Neighboring gene uncharacterized LOC105373971 Neighboring gene anoctamin 7 Neighboring gene high density lipoprotein binding protein Neighboring gene basic proline-rich protein-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme regulator activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase type 1 regulator activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
protein phosphatase 1 regulatory subunit 7
Names
protein phosphatase 1 regulatory subunit 22
protein phosphatase 1, regulatory (inhibitor) subunit 7
protein phosphatase 1, regulatory subunit 7
testis secretory sperm-binding protein Li 210a

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282409.1NP_001269338.1  protein phosphatase 1 regulatory subunit 7 isoform 2

    See identical proteins and their annotated locations for NP_001269338.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded protein (isoform 2, also known as sds22alpha2) is shorter compared to isoform 1.
    Source sequence(s)
    AC005237, BC051689, BM676947
    Consensus CDS
    CCDS63194.1
    UniProtKB/Swiss-Prot
    Q15435
    Related
    ENSP00000272983, OTTHUMP00000200399, ENST00000272983, OTTHUMT00000323554
    Conserved Domains (4) summary
    smart00446
    Location:293311
    LRRcap; occurring C-terminal to leucine-rich repeats
    pfam12799
    Location:187229
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:187243
    LRR_8; Leucine rich repeat
    sd00033
    Location:5778
    LRR_RI; leucine-rich repeat [structural motif]
  2. NM_001282410.1NP_001269339.1  protein phosphatase 1 regulatory subunit 7 isoform 3

    See identical proteins and their annotated locations for NP_001269339.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' structure resulting in a novel 3' coding region and 3' UTR compared to variant 1. The encoded protein (isoform 3, also known as sds22beta1) is shorter compared to isoform 1.
    Source sequence(s)
    AC005237, BC013001, BC051689
    Consensus CDS
    CCDS63192.1
    UniProtKB/Swiss-Prot
    Q15435
    Related
    ENSP00000385022, OTTHUMP00000200381, ENST00000406106, OTTHUMT00000323527
    Conserved Domains (3) summary
    pfam12799
    Location:230272
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:208264
    LRR_8; Leucine rich repeat
    sd00033
    Location:100121
    LRR_RI; leucine-rich repeat [structural motif]
  3. NM_001282411.1NP_001269340.1  protein phosphatase 1 regulatory subunit 7 isoform 4

    See identical proteins and their annotated locations for NP_001269340.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks alternate exons in the coding region and uses an alternate 3' terminal exon compared to variant 1. The encoded protein (isoform 4, also known as sds22beta2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC005237, BC013001, BC051689, BG684153
    Consensus CDS
    CCDS63193.1
    UniProtKB/Swiss-Prot
    Q15435
    Related
    ENSP00000385466, OTTHUMP00000200425, ENST00000401987, OTTHUMT00000323634
    Conserved Domains (3) summary
    pfam12799
    Location:187229
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:165221
    LRR_8; Leucine rich repeat
    sd00033
    Location:5778
    LRR_RI; leucine-rich repeat [structural motif]
  4. NM_001282412.1NP_001269341.1  protein phosphatase 1 regulatory subunit 7 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate 5' structure, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded protein (isoform 5) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC005237, AK308015, BC000910, BM676947, DA787059
    UniProtKB/Swiss-Prot
    Q15435
    Related
    ENSP00000392373, OTTHUMP00000200402, ENST00000450367, OTTHUMT00000323560
    Conserved Domains (4) summary
    smart00446
    Location:320338
    LRRcap; occurring C-terminal to leucine-rich repeats
    pfam12799
    Location:214256
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:214270
    LRR_8; Leucine rich repeat
    sd00033
    Location:84105
    LRR_RI; leucine-rich repeat [structural motif]
  5. NM_001282413.1NP_001269342.1  protein phosphatase 1 regulatory subunit 7 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate 5' structure, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded protein (isoform 6) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC005237, AK308015, BC000910, BI256145, BM676947, DA787059
    UniProtKB/Swiss-Prot
    Q15435
    Related
    ENSP00000412092, OTTHUMP00000200404, ENST00000423280, OTTHUMT00000323563
    Conserved Domains (4) summary
    smart00446
    Location:277295
    LRRcap; occurring C-terminal to leucine-rich repeats
    pfam12799
    Location:171213
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:171227
    LRR_8; Leucine rich repeat
    sd00033
    Location:4162
    LRR_RI; leucine-rich repeat [structural motif]
  6. NM_001282414.1NP_001269343.1  protein phosphatase 1 regulatory subunit 7 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' and 3' UTRs and has multiple coding region differences compared to variant 1. The encoded protein (isoform 7) is shorter and has distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC005237, BC013001, BQ212238, DA787059
    Consensus CDS
    CCDS63190.1
    UniProtKB/Swiss-Prot
    Q15435
    Related
    ENSP00000385012, OTTHUMP00000200403, ENST00000402734, OTTHUMT00000323562
    Conserved Domains (3) summary
    pfam12799
    Location:171213
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:149205
    LRR_8; Leucine rich repeat
    sd00033
    Location:4162
    LRR_RI; leucine-rich repeat [structural motif]
  7. NM_002712.2NP_002703.1  protein phosphatase 1 regulatory subunit 7 isoform 1

    See identical proteins and their annotated locations for NP_002703.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as sds22alpha1).
    Source sequence(s)
    AC005237, BC000910, BC051689, BM676947
    Consensus CDS
    CCDS2546.1
    UniProtKB/Swiss-Prot
    Q15435
    Related
    ENSP00000234038, OTTHUMP00000164571, ENST00000234038, OTTHUMT00000257244
    Conserved Domains (4) summary
    smart00446
    Location:336354
    LRRcap; occurring C-terminal to leucine-rich repeats
    pfam12799
    Location:230272
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:230286
    LRR_8; Leucine rich repeat
    sd00033
    Location:100121
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    241149573..241183650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511388.1XP_011509690.1  

    Conserved Domains (4) summary
    smart00446
    Location:268286
    LRRcap; occurring C-terminal to leucine-rich repeats
    pfam12799
    Location:162204
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:162218
    LRR_8; Leucine rich repeat
    sd00033
    Location:3253
    LRR_RI; leucine-rich repeat [structural motif]

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    242095044..242129164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)