Display Settings:

Format

Send to:

Choose Destination

USP47 ubiquitin specific peptidase 47 [ Homo sapiens (human) ]

Gene ID: 55031, updated on 2-Aug-2015
Official Symbol
USP47provided by HGNC
Official Full Name
ubiquitin specific peptidase 47provided by HGNC
Primary source
HGNC:HGNC:20076
See related
Ensembl:ENSG00000170242; MIM:614460; Vega:OTTHUMG00000165685
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRFP
Orthologs
See USP47 in Epigenomics, MapViewer
Location:
11p15.3
Exon count:
30
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (11841423..11959325)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (11862970..11980872)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene microRNA 4299 Neighboring gene microRNA 8070 Neighboring gene dickkopf WNT signaling pathway inhibitor 3 Neighboring gene uncharacterized LOC105376554

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ20727, DKFZp686C13257

Gene Ontology Provided by GOA

Function Evidence Code Pubs
WD40-repeat domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-specific protease activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
ubiquitin carboxyl-terminal hydrolase 47
Names
Trf (TATA binding protein-related factor)-proximal homolog
deubiquitinating enzyme 47
ubiquitin thioesterase 47
ubiquitin thiolesterase 47
ubiquitin-specific-processing protease 47
NP_001269588.1
NP_060414.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282659.1NP_001269588.1  ubiquitin carboxyl-terminal hydrolase 47 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AI126428, AK027362, AK074076, AK127264, AL832991, BC071559, BM314303, CR749502, DA490237
    Consensus CDS
    CCDS60725.1
    UniProtKB/TrEMBL
    Q68D97
    UniProtKB/Swiss-Prot
    Q96K76
    Conserved Domains (3) summary
    cd02659
    Location:166546
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:167541
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam15497
    Location:860925
    SNAPc19; snRNA-activating protein complex subunit 19, SNAPc subunit 19
  2. NM_017944.3NP_060414.3  ubiquitin carboxyl-terminal hydrolase 47 isoform b

    See identical proteins and their annotated locations for NP_060414.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AC104383, AC124276, AK027362, AK092290, BG752249
    Consensus CDS
    CCDS41619.1
    UniProtKB/Swiss-Prot
    Q96K76
    Related
    ENSP00000339957, OTTHUMP00000230750, ENST00000339865, OTTHUMT00000385793
    Conserved Domains (3) summary
    cd02659
    Location:98478
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:99473
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam15497
    Location:792857
    SNAPc19; snRNA-activating protein complex subunit 19, SNAPc subunit 19

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    11841423..11959325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252997.1XP_005253054.1  

    See identical proteins and their annotated locations for XP_005253054.1

    UniProtKB/Swiss-Prot
    Q96K76
    Related
    ENSP00000382382, OTTHUMP00000230782, ENST00000399455, OTTHUMT00000385853
    Conserved Domains (3) summary
    cd02659
    Location:186566
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:187561
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam15497
    Location:880945
    SNAPc19; snRNA-activating protein complex subunit 19, SNAPc subunit 19
  2. XM_011520196.1XP_011518498.1  

    Conserved Domains (2) summary
    pfam15497
    Location:481546
    SNAPc19; snRNA-activating protein complex subunit 19, SNAPc subunit 19
    cl02553
    Location:1167
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    11862028..11979798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)