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    PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme [ Homo sapiens ]

    Gene ID: 5501, updated on 12-May-2012

    Summary

    Official Symbol
    PPP1CCprovided by HGNC
    Official Full Name
    protein phosphatase 1, catalytic subunit, gamma isozymeprovided by HGNC
    Primary source
    HGNC:9283
    See related
    Ensembl:ENSG00000186298; HPRD:08911; MIM:176914; Vega:OTTHUMG00000169531
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PP-1G; PPP1G
    Summary
    The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

    Genomic context

    Location :
    12q24.1-q24.2
    Sequence :
    Chromosome: 12; NC_000012.11 (111157613..111180783, complement)
    See PPP1CC in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene PTC7 protein phosphatase homolog (S. cerevisiae) Neighboring gene tectonic family member 1 Neighboring gene hydrogen voltage-gated channel 1 Neighboring gene ribosomal protein L29 pseudogene 25 Neighboring gene coiled-coil domain containing 63

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat PP1 interacts with Tat in part through the binding of Val(36) and Phe(38) of Tat to PP1, and Tat is involved in the nuclear and subnuclear targeting of PP1 PubMed
    tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
    tat Stimulation of HIV-1 Tat transactivation by protein phosphatase 1 (PP1) is inhibited by nuclear inhibitor of PP1 (NIPP1), indicating Tat function is regulated by PP1/NIPP1 PubMed
    tat Protein phosphatase 1 (PP1) associates with HIV-1 Tat and stimulates Tat-mediated transactivation of the HIV-1 LTR promoter PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_002701.1 NP_000928.1 POLR2A    BIND  PubMed PPP1CC (TAPP) interacts with and dephosphorylates POLR2A (RNAPII). This interaction was modelled on a demonstrated interaction between human PPP1CC and POLR2A from an unspecified species. 
    P36873 Q9UKA4 AKAP11    HPRD  PubMed  
    P36873 O14965 AURKA    HPRD  PubMed  
    P36873 P19525 EIF2AK2    HPRD  PubMed  
    P36873 P51610 HCFC1    HPRD  PubMed  
    P36873 Myosin heavy chain Myr 8 MYO16    HPRD  PubMed  
    P36873 P41236 PPP1R2    HPRD  PubMed  
    P36873 O95685 PPP1R3D    HPRD  PubMed  
    P36873 Q12972 PPP1R8    HPRD  PubMed  
    P36873 P04049 RAF1    HPRD  PubMed  
    P36873 P06400 RB1    HPRD  PubMed  
    P36873 Q12824 SMARCB1    HPRD  PubMed  
    P36873 P04637 TP53    HPRD  PubMed  
    P36873 Q13625 TP53BP2    HPRD  PubMed  
    P36873 Q9Y2W2 WBP11    HPRD  PubMed  
    P36873 P63104 YWHAZ    HPRD  PubMed  
    P36873 O95405 ZFYVE9    HPRD  PubMed  
    BioGRID:111495 BioGRID:116384 AKAP11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111495 BioGRID:111596 EIF2AK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111495 BioGRID:251366 Eif2b5    BioGRID  PubMed Biochemical Activity 
    BioGRID:111495 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:111495 BioGRID:123818 HDAC10    BioGRID  PubMed Co-purification 
    BioGRID:111495 BioGRID:115330 HDAC6    BioGRID  PubMed Affinity Capture-Western; Co-purification; Far Western; Reconstituted Complex 
    BioGRID:111495 BioGRID:120968 HDAC8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111495 BioGRID:125817 LEO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111495 BioGRID:111580 MAPK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111495 BioGRID:201430 Mki67    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111495 BioGRID:114973 NCOR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111495 BioGRID:110904 NONO    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111495 BioGRID:111506 PPP1R10    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111495 BioGRID:117172 PPP1R15A    BioGRID  PubMed Affinity Capture-Western; Co-purification; Phenotypic Suppression 
    BioGRID:111495 BioGRID:111501 PPP1R3D    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111495 BioGRID:111503 PPP1R8    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111495 BioGRID:124202 PPP1R9B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111495 BioGRID:206343 Ppp1r10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111495 BioGRID:112174 RYR2    BioGRID  PubMed Co-fractionation 
    BioGRID:111495 BioGRID:112482 SMARCB1    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex 
    BioGRID:111495 BioGRID:215561 Sass6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111495 BioGRID:109435 TLX1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111495 BioGRID:115209 TOX4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111495 BioGRID:115457 TRIM28    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111495 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111495 BioGRID:113264 VDR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111495 BioGRID:123245 WDR82    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111495 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 

    General gene information

    Markers

    Homology

    • Homologs of the PPP1CC gene: The PPP1CC gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, S.pombe, A.thaliana, rice, and P.falciparum.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Alcoholism, organism-specific biosystem (from KEGG)
      Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Alcoholism, conserved biosystem (from KEGG)
      Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Amphetamine addiction, organism-specific biosystem (from KEGG)
      Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Amphetamine addiction, conserved biosystem (from KEGG)
      Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Aurora B signaling, organism-specific biosystem (from Pathway Interaction Database)
      Aurora B signaling, organism-specific biosystem
      Aurora B signaling
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • DNA Replication, organism-specific biosystem (from REACTOME)
      DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, organism-specific biosystem (from REACTOME)
      Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, organism-specific biosystemTriacylglycerol is a major energy store in the body and its hydrolysis to yield fatty acids and glycerol is a tightly regulated part of energy metabolism. A central part in this regulation is played ...
    • Insulin signaling pathway, organism-specific biosystem (from KEGG)
      Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Insulin signaling pathway, conserved biosystem (from KEGG)
      Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Insulin-mediated glucose transport, organism-specific biosystem (from Pathway Interaction Database)
      Insulin-mediated glucose transport, organism-specific biosystem
      Insulin-mediated glucose transport
    • Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
      Lipid digestion, mobilization, and transport, organism-specific biosystemProcesses annotated here include the digestion of dietary lipids, sterol uptake, the formation and turnover of lipoproteins (chylomicrons, VLDL, LDL, and HDL), and the mobilization of fatty acids thr...
    • Long-term potentiation, organism-specific biosystem (from KEGG)
      Long-term potentiation, organism-specific biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • Long-term potentiation, conserved biosystem (from KEGG)
      Long-term potentiation, conserved biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • M Phase, organism-specific biosystem (from REACTOME)
      M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Mitotic M-M/G1 phases, organism-specific biosystem (from REACTOME)
      Mitotic M-M/G1 phases, organism-specific biosystem
      Mitotic M-M/G1 phases
    • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
      Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and ...
    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
      Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
      Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
      mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
    • mRNA surveillance pathway, conserved biosystem (from KEGG)
      mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
     
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    M phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    glycogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    lipid metabolic process TAS
    Traceable Author Statement
    more info
     
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    mitotic prometaphase TAS
    Traceable Author Statement
    more info
     
    protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
     
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
     
    triglyceride catabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    MLL5-L complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    PTW/PP1 phosphatase complex IDA
    Inferred from Direct Assay
    more info
     
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    cleavage furrow IEA
    Inferred from Electronic Annotation
    more info
     
    condensed chromosome kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    midbody IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase PP1-gamma catalytic subunit
    Names
    serine/threonine-protein phosphatase PP1-gamma catalytic subunit
    serine/threonine phosphatase 1 gamma
    protein phosphatase 1C catalytic subunit
    protein phosphatase 1, catalytic subunit, gamma isoform
    NP_002701.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030325.1 RefSeqGene

      Range
      5001..28171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001244974.1NP_001231903.1  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs at the 3' end compared to variant 1. This results in a longer isoform (2) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AA781342, AW575661, BC014073, DA514523
      UniProtKB/Swiss-Prot
      P36873
      Conserved Domains (2) summary
      cd07414
      Location:8300
      Blast Score: 1770
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
      PTZ00480
      Location:6313
      Blast Score: 1442
      PTZ00480; serine/threonine-protein phosphatase; Provisional
    2. NM_002710.3NP_002701.1  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1.
      Source sequence(s)
      AW575661, BC014073, DA514523, X74008
      Consensus CDS
      CCDS9150.1
      UniProtKB/Swiss-Prot
      P36873
      Related
      ENSP00000335084, OTTHUMP00000241460, ENST00000335007, OTTHUMT00000404659
      Conserved Domains (2) summary
      cd07414
      Location:8300
      Blast Score: 1767
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
      PTZ00480
      Location:6313
      Blast Score: 1441
      PTZ00480; serine/threonine-protein phosphatase; Provisional

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p5 Primary Assembly

      Range
      111157613..111180783, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      108174950..108198121, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AB030255.2 BAA82664.1
    genomic AC144522.12 (106135..129058) None
    genomic CH471054.1 EAW97938.1
      EAW97939.1
      EAW97940.1
    mRNA AA781342.1 None
    mRNA AK297882.1 BAG60205.1
    mRNA AW575661.1 None
    mRNA BC014073.2 AAH14073.1
    mRNA DA472620.1 None
    mRNA DA514523.1 None
    mRNA L07395.1 AAA19823.1
    mRNA X74008.1 CAA52169.1
    other-genetic EU831993.1 ACE87434.1
    other-genetic EU832086.1 ACE86748.1
    other-genetic JF432841.1 ADZ16058.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36873.1 GenPept UniProtKB/Swiss-Prot:P36873
    Q9UPN1 GenPept UniProtKB/TrEMBL:Q9UPN1

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