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    PAK1IP1 PAK1 interacting protein 1 [ Homo sapiens ]

    Gene ID: 55003, updated on 11-May-2012

    Summary

    Official Symbol
    PAK1IP1provided by HGNC
    Official Full Name
    PAK1 interacting protein 1provided by HGNC
    Primary source
    HGNC:20882
    See related
    Ensembl:ENSG00000111845; HPRD:07424; MIM:607811; Vega:OTTHUMG00000014245
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PIP1; MAK11; WDR84; hPIP1; bA421M1.5; RP11-421M1.5; FLJ20624

    Genomic context

    Location :
    6p24.2
    Sequence :
    Chromosome: 6; NC_000006.11 (10695188..10709972)
    See PAK1IP1 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene glucosaminyl (N-acetyl) transferase 6 Neighboring gene chromosome 6 open reading frame 52 Neighboring gene transmembrane protein 14C Neighboring gene uncharacterized LOC100506379

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9NWT1 Q13153 PAK1    HPRD  PubMed  
    Q9NWT1 Q9HCE7 SMURF1    HPRD  PubMed  
    BioGRID:120335 BioGRID:198025 Agrn    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:120335 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120335 BioGRID:111095 PAK1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:120335 BioGRID:117660 TINF2    BioGRID  PubMed Two-hybrid 

    General gene information

    Markers

    Homology

    • Homologs of the PAK1IP1 gene: The PAK1IP1 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, , , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    p21-activated protein kinase-interacting protein 1
    Names
    p21-activated protein kinase-interacting protein 1
    PAK1-interacting protein 1
    PAK/PLC-interacting protein 1
    WD repeat-containing protein 84

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017906.2NP_060376.2  p21-activated protein kinase-interacting protein 1

      Status: VALIDATED

      Source sequence(s)
      AF283303, BC010907, BU618231
      Consensus CDS
      CCDS34339.1
      UniProtKB/Swiss-Prot
      Q9NWT1
      Related
      ENSP00000368887, OTTHUMP00000016022, ENST00000379568, OTTHUMT00000039835
      Conserved Domains (1) summary
      cd00200
      Location:41275
      Blast Score: 326
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      10695188..10709972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      10570804..10585589
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL358777.12 CAI14002.1
    genomic CH471087.1 EAW55267.1
      EAW55268.1
      EAW55269.1
      EAW55270.1
    mRNA AF283303.1 AAK57477.1
    mRNA AK000631.1 BAA91296.1
    mRNA AK225516.1 None
    mRNA BC010907.1 AAH10907.1
    mRNA BU618231.1 None
    other-genetic DQ892798.2 ABM83724.1
    other-genetic DQ896045.2 ABM87044.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NWT1.2 GenPept UniProtKB/Swiss-Prot:Q9NWT1

      Supplemental Content

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