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    AUP1 ancient ubiquitous protein 1 [ Homo sapiens ]

    Gene ID: 550, updated on 11-May-2012
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    Summary

    Official Symbol
    AUP1provided by HGNC
    Official Full Name
    ancient ubiquitous protein 1provided by HGNC
    Primary source
    HGNC:891
    See related
    Ensembl:ENSG00000115307; HPRD:03892; MIM:602434; Vega:OTTHUMG00000129964
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    2p13
    Sequence :
    Chromosome: 2; NC_000002.11 (74753775..74756974, complement)
    See AUP1 in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene T-cell leukemia homeobox 2 Neighboring gene DEAQ box RNA-dependent ATPase 1 Neighboring gene HtrA serine peptidase 2 Neighboring gene lysyl oxidase-like 3 Neighboring gene docking protein 1, 62kDa (downstream of tyrosine kinase 1) Neighboring gene chromosome 2 open reading frame 65 Neighboring gene torsin family 1, member B (torsin B) pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control. Klemm EJ, et al. J Biol Chem, 2011 Oct 28. PMID 21857022.
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control.
      Title: Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control.
    2. The presence of the AUP1-Ube2g2 complex at LDs provides a direct molecular link between LDs and the cellular ubiquitination machinery.
      Title: Ancient ubiquitous protein 1 (AUP1) localizes to lipid droplets and binds the E2 ubiquitin conjugase G2 (Ube2g2) via its G2 binding region.
    3. molecular cloning and sequencing of cDNA and preliminary characterization of protein
      Title: [A new human cellular protein AUP1. II. cDNA cloning, genomic organization of Aup1 gene ans preliminary characterization of human AUP1 protein].
    4. binding of Aup1 plays a crucial role in the alpha(IIb)beta(3) inside-out signaling
      Title: Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9Y679 P56199 ITGA1    HPRD  PubMed  
    Q9Y679 P17301 ITGA2    HPRD  PubMed  
    Q9Y679 P08514 ITGA2B    HPRD  PubMed  
    Q9Y679 P08648 ITGA5    HPRD  PubMed  
    Q9Y679 P11215 ITGAM    HPRD  PubMed  
    Q9Y679 P06756 ITGAV    HPRD  PubMed  
    BioGRID:107031 BioGRID:114587 ATG12    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107031 BioGRID:107612 CLN3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107031 BioGRID:109824 ILK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107031 BioGRID:109879 ITGA1    BioGRID  PubMed Two-hybrid 
    BioGRID:107031 BioGRID:109880 ITGA2    BioGRID  PubMed Two-hybrid 
    BioGRID:107031 BioGRID:109881 ITGA2B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107031 BioGRID:109884 ITGA5    BioGRID  PubMed Two-hybrid 
    BioGRID:107031 BioGRID:109890 ITGAM    BioGRID  PubMed Two-hybrid 
    BioGRID:107031 BioGRID:109891 ITGAV    BioGRID  PubMed Two-hybrid 
    BioGRID:107031 BioGRID:116306 KPTN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107031 BioGRID:110772 NDN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107031 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107031 BioGRID:113175 UBE2G2    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    ancient ubiquitous protein 1
    Names
    ancient ubiquitous protein 1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181575.3 → NP_853553.1  ancient ubiquitous protein 1

      Status: REVIEWED

      Source sequence(s)
      AC005041, AI206563
      Consensus CDS
      CCDS42702.1
      UniProtKB/Swiss-Prot
      Q9Y679
      Related
      ENSP00000366748, OTTHUMP00000160424, ENST00000377526, OTTHUMT00000252228
      Conserved Domains (2) summary
      cl02655
      Location:296 – 336
      Blast Score: 115
      CUE; CUE domain
      cl00357
      Location:66 – 264
      Blast Score: 193
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      74753775..74756974, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      74490036..74493235, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_012103.2: Suppressed sequence

      Description
      NM_012103.2: This RefSeq was permanently suppressed because it contains the wrong CDS due to a frameshift mutation in the coding region. Correction of the mutation produces a transcript that is a candidate for nonsense-mediated d

    2. NM_181576.1: Suppressed sequence

      Description
      NM_181576.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC005041.2 (5451..8651) None
    genomic CH471053.2 EAW99622.1
      EAW99623.1
      EAW99624.1
      EAW99625.1
    mRNA AF100746.1 AAD43010.1
    mRNA AF100753.1 AAD43017.1
    mRNA AF100754.1 AAD43018.1
    mRNA AF165515.1 AAF86645.1
    mRNA AI206563.1 None
    mRNA AK023983.1 BAB14753.1
    mRNA AK055566.1 None
    mRNA AK293121.1 BAF85810.1
    mRNA AK301398.1 BAG62933.1
    mRNA AK304886.1 BAG65623.1
    mRNA AK308231.1 None
    mRNA AK310159.1 None
    mRNA BC001658.1 AAH01658.1
    mRNA BC033646.2 AAH33646.2
    mRNA CR999537.1 None
    mRNA CR749661.1 CAH18454.2
    other-genetic EU831790.1 ACE87308.1
    other-genetic EU831868.1 ACE86627.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68CX8 GenPept UniProtKB/TrEMBL:Q68CX8
    Q9Y679.1 GenPept UniProtKB/Swiss-Prot:Q9Y679
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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