ACPP acid phosphatase, prostate [Homo sapiens] - Gene

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Summary

Official Symbol: ACPPprovided by HGNC
Official Full Name: acid phosphatase, prostateprovided by HGNC
Primary source: HGNC:125
See related: Ensembl:ENSG00000014257; HPRD:01378; MIM:171790; Vega:OTTHUMG00000159650
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PAP; ACP3; 5'-NT; ACP-3
Summary: This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]

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Genomic context

Location :: 3q22.1

Sequence :: Chromosome: 3; NC_000003.11 (132036211..132087146)

See ACPP in Epigenomics, MapViewer

Chromosome 3 - NC_000003.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Peptide fragments derived from N-proximal and C-proximal of the PAP form fibrillar structures and increase virion attachment to cells.
Title: Naturally occurring fragments from two distinct regions of the prostatic acid phosphatase form amyloidogenic enhancers of HIV infection.
PAP is strongly expressed in prostate cancer bone metastases in 7/7 patients, while prostate-specific antigen (PSA) is only weakly expressed.
Title: Prostatic acid phosphatase is expressed in human prostate cancer bone metastases and promotes osteoblast differentiation.
Our studies confirmed that, while prostatic acid phosphatase expression is not restricted to prostate tissues, its expression in other human tissues is approximately 1-2 orders of magnitude less than that observed in the prostate.
Title: Prostatic acid phosphatase expression in human tissues.
Most of the features of PAP including gene regulation, gene/protein structure, functions, its role in tumor progression and evolutionary features are discussed. Review.
Title: Structural and functional analysis of human prostatic acid phosphatase.
prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth
Title: Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth.
Data show that prostatic acid phosphatase(PAP) as a sensitive tumor marker for prostate cancer.
Title: Protein complexes/aggregates as potential cancer biomarkers revealed by a nanoparticle aggregation immunoassay.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
PSAP might be predictive of tumor stage in incidental prostate cancer and represent a valuable adjunct for clinical decisions in terms of individual therapeutic management.
Title: Expression of prostatic acid phosphatase (PSAP) in transurethral resection specimens of the prostate is predictive of histopathologic tumor stage in subsequent radical prostatectomies.
The obtained N-terminal amino-acid sequence of boar PTAP showed 92% identity with the N-terminal amino-acid sequence of human PAP. The determined sequence of a 354 bp nucleotide fragment showed 90% identity with the corresponding sequence of human PAP.
Title: High sequence homology between protein tyrosine acid phosphatase from boar seminal vesicles and human prostatic acid phosphatase.
molecular details of PAPf39 peptide fibril formation may aid in elucidating the mechanism of how PAPf39 fibrils are involved in HIV etiology
Title: Mechanism of fibril formation by a 39-residue peptide (PAPf39) from human prostatic acidic phosphatase.

Submit: New GeneRIF Correction See all (29)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P15309	P15309	ACPP	HPRD	PubMed
P15309	P04626	ERBB2	HPRD	PubMed
P15309	P04278	SHBG	HPRD	PubMed
BioGRID:106571	BioGRID:106571	ACPP	BioGRID	PubMed	Co-crystal Structure
BioGRID:106571	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
5'-nucleotidase activity	IEA Inferred from Electronic Annotation more info
acid phosphatase activity	IEA Inferred from Electronic Annotation more info
hydrolase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
extracellular region	IEA Inferred from Electronic Annotation more info
intracellular	IDA Inferred from Direct Assay more info	PubMed
lysosomal membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: prostatic acid phosphatase

Names: prostatic acid phosphatase; TMPase; 5'-nucleotidase; ecto-5'-nucleotidase; thiamine monophosphatase; prostatic acid phosphotase

NP_001090.2

EC 3.1.3.2

EC 3.1.3.5

NP_001127666.1

EC 3.1.3.2

EC 3.1.3.5

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099.4 → NP_001090.2 prostatic acid phosphatase isoform PAP precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes the shorter, secreted isoform (PAP).

Source sequence(s)

AA578274, AC020633, BC008493, BC016344, DC383453

Consensus CDS

CCDS3073.1

UniProtKB/Swiss-Prot

P15309

Related

ENSP00000337471, OTTHUMP00000216106, ENST00000336375, OTTHUMT00000356699

Conserved Domains (1) summary

cd07061
Location:34 – 332
Blast Score: 397

HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction.
NM_001134194.1 → NP_001127666.1 prostatic acid phosphatase isoform TM-PAP precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs at the 3' end compared to variant 1, and encodes a longer isoform (TM-PAP) with a distinct C-terminus compared to isoform PAP. TM-PAP is a type 1 transmembrane protein.

Source sequence(s)

AW136372, BC007460, BC008493, BQ100881, DC383453

Consensus CDS

CCDS46916.1

UniProtKB/Swiss-Prot

P15309

Related

ENSP00000323036, OTTHUMP00000216108, ENST00000351273, OTTHUMT00000356701

Conserved Domains (1) summary

cd07061
Location:34 – 332
Blast Score: 398

HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction.

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000003.11 Reference GRCh37.p5 Primary Assembly

Range

132036211..132087146

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000135.1 Alternate HuRef

Range

129415425..129466393

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC020633.3 (87007..128428)	None
genomic	CH471052.2	EAW79201.1
		EAW79202.1
		EAW79203.1
		EAW79204.1
		EAW79205.1
genomic	M97589.1	AAA60021.1
genomic	U07086.1	AAB60640.1
genomic	U07097.1	AAB60640.1
genomic	X71391.1	CAA50514.1
genomic	X74961.1	CAA52913.1
mRNA	AA578274.1	None
mRNA	AB102888.1	BAD89417.1
mRNA	AK300540.1	BAG62248.1
mRNA	AW136372.1	None
mRNA	BC007460.1	AAH07460.1
mRNA	BC008493.1	AAH08493.1
mRNA	BC016344.1	AAH16344.1
mRNA	BC017877.1	AAH17877.1
mRNA	BQ100881.1	None
mRNA	DC383453.1	None
mRNA	M24902.1	AAA60022.1
mRNA	M34840.1	AAA69694.1
mRNA	X52174.1	CAA36422.1
mRNA	X53605.1	CAA37673.1
other-genetic	DQ893148.2	ABM84074.1
other-genetic	DQ896443.2	ABM87442.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P15309.3	GenPept	UniProtKB/Swiss-Prot:P15309
Q5FBY0	GenPept	UniProtKB/TrEMBL:Q5FBY0
Q6LBH1	GenPept	UniProtKB/TrEMBL:Q6LBH1