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    AURKAIP1 aurora kinase A interacting protein 1 [ Homo sapiens ]

    Gene ID: 54998, updated on 11-May-2012
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    Summary

    Official Symbol
    AURKAIP1provided by HGNC
    Official Full Name
    aurora kinase A interacting protein 1provided by HGNC
    Primary source
    HGNC:24114
    See related
    Ensembl:ENSG00000175756; HPRD:16457; MIM:609183; Vega:OTTHUMG00000001413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AIP; AKIP; FLJ20608
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    Genomic context

    Location :
    1p36.33
    Sequence :
    Chromosome: 1; NC_000001.10 (1309110..1310818, complement)
    See AURKAIP1 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene dishevelled, dsh homolog 1 (Drosophila) Neighboring gene matrix-remodelling associated 8 Neighboring gene cyclin L2 Neighboring gene uncharacterized LOC148413 Neighboring gene mitochondrial ribosomal protein L20

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Capsaicin induces apoptosis of cisplatin-resistant stomach cancer cells by causing degradation of cisplatin-inducible Aurora-A protein. Huh HC, et al. Nutr Cancer, 2011. PMID 21932983.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. Hendrickson SL, et al. PLoS One, 2010 Sep 21. PMID 20877624.
    4. The inhibition of Aurora A abrogates the mitotic delay induced by microtubule perturbing agents. Wysong DR, et al. Cell Cycle, 2009 Mar 15. PMID 19221504.
    5. Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora. Chan EH, et al. Chromosoma, 2008 Oct. PMID 18521620.

    See all (20) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Aurora-A protein increased in stomach cancer cells in response to cisplatin and was degraded upon combined treatment with capsaicin with cisplatin.
      Title: Capsaicin induces apoptosis of cisplatin-resistant stomach cancer cells by causing degradation of cisplatin-inducible Aurora-A protein.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    3. Aurora A is necessary for the maintenance of the mitotic delay induced in response to microtubule-perturbing agents.
      Title: The inhibition of Aurora A abrogates the mitotic delay induced by microtubule perturbing agents.
    4. Plk1 controls Aurora A localization and function by regulating cellular levels of hBora.
      Title: Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora.
    5. GSK-3beta modulates the early mitotic Aurora-A level through binding and phosphorylating AIP.
      Title: AIP regulates stability of Aurora-A at early mitotic phase coordinately with GSK-3beta.
    6. AKURA phosphorylation of AIP and stabilization of the enzyme-substrate complex are reported.
      Title: Aurora-A kinase phosphorylation of Aurora-A kinase interacting protein (AIP) and stabilization of the enzyme-substrate complex.
    7. We propose that AURKAIP1 might function upstream of the Az1 by enhancing the binding affinity of Az1 to Aurora-A to promote recognition, targeting to proteasome and subsequent degradation.
      Title: Antizyme1 mediates AURKAIP1-dependent degradation of Aurora-A.
    8. Results describe the identification of a novel negative regulator of Aurora-A, named AIP (Aurora-A kinase Interacting Protein).
      Title: Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase.
    9. Phe31Ile polymorphism in Aurora A may be a genetic modifier for developing breast carcinoma.
      Title: Functional Phe31Ile polymorphism in Aurora A and risk of breast carcinoma.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9NWT8 Ajuba AJUBA    HPRD  PubMed  
    Q9NWT8 O14965 AURKA    HPRD  PubMed  
    Q9NWT8 Q9NWT8 AURKAIP1    HPRD  PubMed  
    BioGRID:120331 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    negative regulation of mitosis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    positive regulation of proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    aurora kinase A-interacting protein
    Names
    aurora kinase A-interacting protein
    AURKA-interacting protein
    aurora-A kinase interacting protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127229.1 → NP_001120701.1  aurora kinase A-interacting protein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a 5'UTR resulting from use of an alternate splice donor site.
      Source sequence(s)
      AK000615, AW576100, BM781908, F31434
      Consensus CDS
      CCDS25.1
      UniProtKB/Swiss-Prot
      Q9NWT8
      Related
      ENSP00000368130, OTTHUMP00000003015, ENST00000378853, OTTHUMT00000008274
      Conserved Domains (1) summary
      pfam08213
      Location:126 – 159
      Blast Score: 118
      DUF1713; Mitochondrial domain of unknown function (DUF1713)

    2. NM_001127230.1 → NP_001120702.1  aurora kinase A-interacting protein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has a 5'UTR resulting from use of an alternate splice donor site.
      Source sequence(s)
      AJ573456, BC022808, BC062333, BE903314, BP198074, DN994953
      Consensus CDS
      CCDS25.1
      UniProtKB/Swiss-Prot
      Q9NWT8
      Related
      ENSP00000319778, OTTHUMP00000003016, ENST00000321751, OTTHUMT00000008277
      Conserved Domains (1) summary
      pfam08213
      Location:126 – 159
      Blast Score: 118
      DUF1713; Mitochondrial domain of unknown function (DUF1713)

    3. NM_017900.2 → NP_060370.1  aurora kinase A-interacting protein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) has a 5'UTR resulting from use of an alternate splice donor site.
      Source sequence(s)
      AK000615, AL139287, BC062333, BF664406, BG764236
      Consensus CDS
      CCDS25.1
      UniProtKB/Swiss-Prot
      Q9NWT8
      Related
      ENSP00000340656, OTTHUMP00000001518, ENST00000338338, OTTHUMT00000004082
      Conserved Domains (1) summary
      pfam08213
      Location:126 – 159
      Blast Score: 118
      DUF1713; Mitochondrial domain of unknown function (DUF1713)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      1309110..1310818, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      581461..583169, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC026283.2 (189514..190984) None
    genomic AL139287.24 CAI23191.1
    genomic CH471183.1 EAW56218.1
      EAW56219.1
    mRNA AJ573456.1 None
    mRNA AK000615.1 BAA91289.1
    mRNA AW576100.1 None
    mRNA BC022808.1 AAH22808.1
    mRNA BC035595.1 None
    mRNA BC046345.2 AAH46345.1
    mRNA BC062333.1 AAH62333.1
    mRNA BE903314.1 None
    mRNA BF664406.1 None
    mRNA BG764236.1 None
    mRNA BM781908.1 None
    mRNA BP198074.1 None
    mRNA DN994953.1 None
    mRNA F31434.1 None
    other-genetic HQ447642.1 ADQ32127.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PI41 GenPept UniProtKB/TrEMBL:Q6PI41
    Q9NWT8.1 GenPept UniProtKB/Swiss-Prot:Q9NWT8
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
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    Tools
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