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psen2 presenilin 2 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 549935, updated on 7-Sep-2023

Summary

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Official Symbol
psen2provided by Xenbase
Official Full Name
presenilin 2provided by Xenbase
Primary source
Xenbase:XB-GENE-854877
See related
Ensembl:ENSXETG00000008548
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
ad4; ps2; ad3l; ps-a; ps-b; stm2; X-ps-a; X-ps-b; ps-beta; ps-alpha
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Genomic context

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See psen2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
11
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 5 NC_030681.2 (51178163..51192461, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 5 NC_030681.1 (40534642..40548943, complement)

Chromosome 5 - NC_030681.2Genomic Context describing neighboring genes Neighboring gene thrombospondin 2 Neighboring gene dpy-30, histone methyltransferase complex regulatory subunit Neighboring gene mediator of cell motility 1 Neighboring gene steroid 5 alpha-reductase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables aspartic endopeptidase activity, intramembrane cleaving IEA
Inferred from Electronic Annotation
more info
  
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
presenilin-2
Names
presenilin 2 (Alzheimer disease 4)
presenilin-alpha
presenilin-beta
NP_001017181.1
XP_012818512.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017181.2 → NP_001017181.1  presenilin-2

    See identical proteins and their annotated locations for NP_001017181.1

    Status: PROVISIONAL

    Source sequence(s)
    CR760673
    UniProtKB/TrEMBL
    A0A6I8RBP0, Q28HZ1
    Related
    ENSXETP00000018712.3, ENSXETT00000018712.5
    Conserved Domains (1) summary
    pfam01080
    Location:87 → 441
    Presenilin; Presenilin

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030681.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    51178163..51192461 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012963058.3 → XP_012818512.1  presenilin-2 isoform X1

    UniProtKB/TrEMBL
    A0A6I8RBP0, F7C949
    Conserved Domains (1) summary
    pfam01080
    Location:87 → 441
    Presenilin
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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