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    PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme [ Homo sapiens ]

    Gene ID: 5499, updated on 20-May-2012
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    Summary

    Official Symbol
    PPP1CAprovided by HGNC
    Official Full Name
    protein phosphatase 1, catalytic subunit, alpha isozymeprovided by HGNC
    Primary source
    HGNC:9281
    See related
    Ensembl:ENSG00000172531; HPRD:15942; MIM:176875; Vega:OTTHUMG00000167671
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PP-1A; PPP1A; PP1alpha; MGC1674; MGC15877
    Summary
    The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    11q13
    Sequence :
    Chromosome: 11; NC_000011.9 (67165652..67169376, complement)
    See PPP1CA in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100130987 Neighboring gene polymerase (DNA-directed), delta 4, accessory subunit Neighboring gene cardiotrophin-like cytokine factor 1 Neighboring gene RAD9 homolog A (S. pombe) Neighboring gene TBC1 domain family, member 10C Neighboring gene carnosine synthase 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Protein phosphatase 1α interacting proteins in the human brain. Esteves SL, et al. OMICS, 2012 Jan-Feb. PMID 22321011.
    2. Protein phosphatase 1α mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase. Canals D, et al. J Biol Chem, 2012 Mar 23. PMID 22311981.
    3. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094.
    4. PP1A-mediated dephosphorylation positively regulates YAP2 activity. Wang P, et al. PLoS One, 2011. PMID 21909427.
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.

    See all (121) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. a novel, acute mechanism of ERM regulation dependent on PP1alpha and plasma membrane ceramide.
      Title: Protein phosphatase 1α mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase.
    2. Changes in cell polarity proteins Par-3 and PP-1 are associated with altered expression and assembly of tight junction proteins claudin-2, -3, -5 and -7 and ZO-1, causing paracellular leakage in active coeliac disease.
      Title: Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in coeliac disease.
    3. These findings define a novel molecular mechanism that YAP2 is positively regulated by PP1-mediated dephosphorylation in the cell survival.
      Title: PP1A-mediated dephosphorylation positively regulates YAP2 activity.
    4. Results demonstrate that PP1-mediated inhibition of the key anti-apoptotic protein, Akt, plays an important role in SPH-mediated apoptosis in Jurkat cells.
      Title: Protein phosphatase 1-dependent dephosphorylation of Akt is the prime signaling event in sphingosine-induced apoptosis in Jurkat cells.
    5. Results identify a molecular pathway by which leptin confers inhibitory action on insulin secretion, and impaired PP-1 inhibition by leptin may be involved in dysfunction of the adipoinsular axis during the development of hyperinsulinemia and NIDDM.
      Title: Protein phosphatase 1 (PP-1)-dependent inhibition of insulin secretion by leptin in INS-1 pancreatic β-cells and human pancreatic islets.
    6. PP1A and ASPP2 play a critical role in promoting TAZ function by antagonizing the LATS kinase through TAZ dephosphorylation.
      Title: PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ.
    7. The deregulation of cellular NIPP1/PP1 holoenzyme affects RNAPII phosphorylation and pointing to NIPP1 as a potential regulatory factor in RNAPII-mediated transcription.
      Title: Mass spectrometry and biochemical analysis of RNA polymerase II: targeting by protein phosphatase-1.
    8. Could use the urinary hTERT, SENP1, PPP1CA, and MCM5 mRNA to detect bladder cancer recurrence.
      Title: Prediction and diagnosis of bladder cancer recurrence based on urinary content of hTERT, SENP1, PPP1CA, and MCM5 transcripts.
    9. PP-1 ( PP-1alpha or PP-1beta ) acts as a major phosphatase to dephosphorylate AKT1 at Thr-450 and thus modulate its functions in regulating gene expression, cell survival and differentiation.
      Title: Protein phosphatase-1 regulates Akt1 signal transduction pathway to control gene expression, cell survival and differentiation.
    10. CSK21 and PP1A, whose functions are intimately associated with cell cycle regulation, might play key role in gliomagenesis.
      Title: Glioblastoma-specific protein interaction network identifies PP1A and CSK21 as connecting molecules between cell cycle-associated genes.
    Submit: New GeneRIF Correction See all (31)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat PP1 interacts with Tat in part through the binding of Val(36) and Phe(38) of Tat to PP1, and Tat is involved in the nuclear and subnuclear targeting of PP1 PubMed
    tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
    tat Stimulation of HIV-1 Tat transactivation by protein phosphatase 1 (PP1) is inhibited by nuclear inhibitor of PP1 (NIPP1), indicating Tat function is regulated by PP1/NIPP1 PubMed
    tat Protein phosphatase 1 (PP1) associates with HIV-1 Tat and stimulates Tat-mediated transactivation of the HIV-1 LTR promoter PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_002699.1 NP_001744.2 CAV1    BIND  PubMed CAV1 interacts with PP1-C. 
    P62136 Q92667 AKAP1    HPRD  PubMed  
    P62136 Q9UKA4 AKAP11    HPRD  PubMed  
    P62136 Q99996 AKAP9    HPRD  PubMed  
    P62136 O14727 APAF1    HPRD  PubMed  
    P62136 O14965 AURKA    HPRD  PubMed  
    P62136 Q92934 BAD    HPRD  PubMed  
    P62136 Q07814 BAX    HPRD  PubMed  
    P62136 P10415 BCL2    HPRD  PubMed  
    P62136 Q07817 BCL2L1    HPRD  PubMed  
    P62136 Q92843 BCL2L2    HPRD  PubMed  
    P62136 P38398 BRCA1    HPRD  PubMed  
    P62136 Q5TID7 C1orf114    HPRD  PubMed  
    P62136 P27708 CAD    HPRD  PubMed  
    P62136 Q8NG31 CASC5    HPRD  PubMed  
    P62136 Q99459 CDC5L    HPRD  PubMed  
    P62136 P12830 CDH1    HPRD  PubMed  
    P62136 Q9H175 CSRNP2    HPRD  PubMed  
    P62136 Q13616 CUL1    HPRD  PubMed  
    P62136 O43602 DCX    HPRD  PubMed  
    P62136 P19525 EIF2AK2    HPRD  PubMed  
    P62136 O00168 FXYD1    HPRD  PubMed  
    P62136 P16104 H2AFX    HPRD  PubMed  
    P62136 Hairy/enhancer-of-split related with YRPW motif-like HEYL    HPRD  PubMed  
    P62136 P34932 HSPA4    HPRD  PubMed  
    P62136 Q02363 ID2    HPRD  PubMed  
    P62136 Q14678 KANK1    HPRD  PubMed  
    P62136 Q9H1H9 KIF13A    HPRD  PubMed  
    P62136 Q8NI77 KIF18A    HPRD  PubMed  
    P62136 P28482 MAPK1    HPRD  PubMed  
    P62136 P27361 MAPK3    HPRD  PubMed  
    P62136 Myosin heavy chain Myr 8 MYO16    HPRD  PubMed  
    P62136 P51955 NEK2    HPRD  PubMed  
    P62136 Nucleolar protein with MIF4G domain 1 NOM1    HPRD  PubMed  
    P62136 O60245 PCDH7    HPRD  PubMed  
    P62136 P12004 PCNA    HPRD  PubMed  
    P62136 Q9C0D0 PHACTR1    HPRD  PubMed  
    P62136 Q96KR7 PHACTR3    HPRD  PubMed  
    P62136 Phosphatase and actin regulator 4 PHACTR4    HPRD  PubMed  
    P62136 Phospholipase C like 2 PLCL2    HPRD  PubMed  
    P62136 P62136 PPP1CA    HPRD  PubMed  
    P62136 Q96QC0 PPP1R10    HPRD  PubMed  
    P62136 O60927 PPP1R11    HPRD  PubMed  
    P62136 Q96KQ4 PPP1R13B    HPRD  PubMed  
    P62136 Q8WUF5 PPP1R13L    HPRD  PubMed  
    P62136 Protein phosphatase 1, regulatory subunit 15A PPP1R15A    HPRD  PubMed  
    P62136 Protein phosphatase 1, regulatory subunit 15B PPP1R15B    HPRD  PubMed  
    P62136 Q6NYC8 PPP1R18    HPRD  PubMed  
    P62136 Q9UD71 PPP1R1B    HPRD  PubMed  
    P62136 P41236 PPP1R2    HPRD  PubMed  
    P62136 Protein phosphatase 1 regulatory subunit 3B PPP1R3B    HPRD  PubMed  
    P62136 Q12972 PPP1R8    HPRD  PubMed  
    P62136 Q9ULJ8 PPP1R9A    HPRD  PubMed  
    P62136 Q96SB3 PPP1R9B    HPRD  PubMed  
    P62136 Protein phosphatase 2A, catalytic subunit, alpha isoform PPP2CA    HPRD  PubMed  
    P62136 Q05655 PRKCD    HPRD  PubMed  
    P62136 P60484 PTEN    HPRD  PubMed  
    P62136 P06400 RB1    HPRD  PubMed  
    P62136 P63208 SKP1    HPRD  PubMed  
    P62136 Q7Z699 SPRED1    HPRD  PubMed  
    P62136 Q92783 STAM    HPRD  PubMed  
    P62136 O95793 STAU1    HPRD  PubMed  
    P62136 Q9HCH5 SYTL2    HPRD  PubMed  
    P62136 P04637 TP53    HPRD  PubMed  
    P62136 Q13625 TP53BP2    HPRD  PubMed  
    P62136 C9orf75 protein TPRN    HPRD  PubMed  
    P62136 Q13454 TUSC3    HPRD  PubMed  
    P62136 P11473 VDR    HPRD  PubMed  
    P62136 YLP motif containing 1 YLPM1    HPRD  PubMed  
    P62136 Q7Z3T8 ZFYVE16    HPRD  PubMed  
    P62136 O95405 ZFYVE9    HPRD  PubMed  
    P62136 Type 1 protein phosphatase inhibitor     HPRD  PubMed  
    BioGRID:111493 BioGRID:114984 AATK    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:106573 ACTA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111493 BioGRID:116384 AKAP11    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111493 BioGRID:107070 BCL2L1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111493 BioGRID:107071 BCL2L2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111493 BioGRID:107140 BRCA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111493 BioGRID:124007 BTBD10    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:107173 C1QA    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:113725 CCDC6    BioGRID  PubMed Co-localization 
    BioGRID:111493 BioGRID:107424 CDC5L    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:111493 BioGRID:115193 CEP170    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:107572 CKB    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:107595 CLCN2    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:107623 CLTC    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:107667 CNP    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:127882 CNST    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:107672 CNTN1    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:107775 CREB1    BioGRID  PubMed Biochemical Activity 
    BioGRID:111493 BioGRID:107788 CRK    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:122227 CSRNP1    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:122475 CUEDC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111493 BioGRID:119045 CXXC1    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:198624 Cdk1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111493 BioGRID:108007 DCTN1    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:115777 DEAF1    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:114265 EED    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111493 BioGRID:111596 EIF2AK2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:111493 BioGRID:251366 Eif2b5    BioGRID  PubMed Biochemical Activity 
    BioGRID:111493 BioGRID:115105 FRMPD4    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:126842 GLIPR1L2    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:119021 GLTSCR2    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:109187 GSK3B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111493 BioGRID:109304 HCFC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111493 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111493 BioGRID:109544 HSPA8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111493 BioGRID:117474 IBTK    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:109767 IKBKB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111493 BioGRID:121492 JPH3    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:116798 KANK1    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:109985 KCNQ1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111493 BioGRID:128809 KCTD20    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:121617 KIAA1377    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:116524 LMTK2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:111493 BioGRID:115019 LPIN2    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:110272 MAFG    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:125321 MAL2    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:114838 MAP4K4    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:121947 MIIP    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111493 BioGRID:114973 NCOR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111493 BioGRID:110773 NDP    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:110826 NEK2    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:117586 NOC2L    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111493 BioGRID:110904 NONO    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:111493 BioGRID:128746 PHACTR1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111493 BioGRID:125483 PHACTR3    BioGRID  PubMed Affinity Capture-Western; Far Western; Two-hybrid 
    BioGRID:111493 BioGRID:108233 PHC1    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:114124 PIAS1    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:115673 PIAS3    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:111506 PPP1R10    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111493 BioGRID:116948 PPP1R13B    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:116059 PPP1R13L    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:117172 PPP1R15A    BioGRID  PubMed Affinity Capture-Western; Phenotypic Suppression 
    BioGRID:111493 BioGRID:124355 PPP1R15B    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:124414 PPP1R16A    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:128092 PPP1R18    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:111497 PPP1R2    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:111500 PPP1R3C    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:111501 PPP1R3D    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:124753 PPP1R3E    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:572922 PPP1R3G    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:111503 PPP1R8    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111493 BioGRID:124202 PPP1R9B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111493 BioGRID:121633 PREX1    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:119481 PRR16    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:202013 Pafah1b1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111493 BioGRID:206343 Ppp1r10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111493 BioGRID:115359 RANBP9    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:120482 RIF1    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:122959 RPAP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111493 BioGRID:122783 RPAP3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111493 BioGRID:116852 RPRD2    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:116708 RRP1B    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:111493 BioGRID:116067 RUVBL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111493 BioGRID:112174 RYR2    BioGRID  PubMed Co-fractionation 
    BioGRID:111493 BioGRID:215383 Rrp1b    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111493 BioGRID:112319 SFPQ    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:111493 BioGRID:127517 SH3RF2    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:119116 SLC45A1    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:112482 SMARCB1    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex 
    BioGRID:111493 BioGRID:114986 SNCAIP    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:112536 SORL1    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:127800 SPRED1    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:112657 STAU1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111493 BioGRID:215561 Sass6    BioGRID  PubMed Affinity Capture-MS 
    NP_004603.1 TGFBR1    BIND  PubMed T-beta-RI interacts with an unspecific isoform of PPP1C. This interaction was modeled on a demonstrated interaction between human T-beta-RI and mouse PPP1C. 
    NP_003233.3 TGFBR2    BIND  PubMed T-beta-RII interacts with an unspecific isoform of PPP1C. This interaction was modeled on a demonstrated interaction between human T-beta-RII and mouse PPP1C. 
    BioGRID:111493 BioGRID:117543 TOR1AIP1    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:115209 TOX4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111493 BioGRID:113012 TP53BP2    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:130345 TPRN    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:115457 TRIM28    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex 
    BioGRID:111493 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111493 BioGRID:122419 UBE2Z    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:113996 ULK1    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:119702 WBP11    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:123245 WDR82    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111493 BioGRID:121117 YLPM1    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:118005 ZBTB11    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:114773 ZFYVE9    BioGRID  PubMed Two-hybrid 
    BioGRID:111493 BioGRID:127447 ZNF827    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • ALK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      ALK1 signaling events, organism-specific biosystem
      ALK1 signaling events
    • Alcoholism, organism-specific biosystem (from KEGG)
      Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Alcoholism, conserved biosystem (from KEGG)
      Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Amphetamine addiction, organism-specific biosystem (from KEGG)
      Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Amphetamine addiction, conserved biosystem (from KEGG)
      Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • BMP receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      BMP receptor signaling, organism-specific biosystem
      BMP receptor signaling
    • DARPP-32 events, organism-specific biosystem (from REACTOME)
      DARPP-32 events, organism-specific biosystemDopamine- and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), was identified as a major target for dopamine and protein kinase A (PKA) in striatum. Recent advances now indicate that regulation D...
    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, organism-specific biosystem (from REACTOME)
      Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, organism-specific biosystemTriacylglycerol is a major energy store in the body and its hydrolysis to yield fatty acids and glycerol is a tightly regulated part of energy metabolism. A central part in this regulation is played ...
    • Insulin signaling pathway, organism-specific biosystem (from KEGG)
      Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Insulin signaling pathway, conserved biosystem (from KEGG)
      Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
      Lipid digestion, mobilization, and transport, organism-specific biosystemProcesses annotated here include the digestion of dietary lipids, sterol uptake, the formation and turnover of lipoproteins (chylomicrons, VLDL, LDL, and HDL), and the mobilization of fatty acids thr...
    • Long-term potentiation, organism-specific biosystem (from KEGG)
      Long-term potentiation, organism-specific biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • Long-term potentiation, conserved biosystem (from KEGG)
      Long-term potentiation, conserved biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Nicotine Activity on Dopaminergic Neurons, organism-specific biosystem (from WikiPathways)
      Nicotine Activity on Dopaminergic Neurons, organism-specific biosystemNicotine is an alkaloid found in tobacco plants. It is a substance that acts as a stimulant in humans and is one of the main factors responsible for tobacco dependence. When nicotine enters the body,...
    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Opioid Signalling, organism-specific biosystem (from REACTOME)
      Opioid Signalling, organism-specific biosystemOpioids are chemical substances similar to opiates, the active substances found in opium (morphine, codeine etc.). Opioid action is mediated by the receptors for endogenous opioids; peptides such as...
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • TGF-beta receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      TGF-beta receptor signaling, organism-specific biosystem
      TGF-beta receptor signaling
    • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
      Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
      Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
      mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
    • mRNA surveillance pathway, conserved biosystem (from KEGG)
      mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein phosphatase type 1 regulator activity TAS
    Traceable Author Statement
    more info
    		  
    protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine phosphatase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    ribonucleoprotein complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    branching morphogenesis of a tube IEA
    Inferred from Electronic Annotation
    more info
    		  
    carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    glycogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    lipid metabolic process TAS
    Traceable Author Statement
    more info
    		  
    lung development IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein dephosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of glycogen catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
    		  
    triglyceride catabolic process TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    MLL5-L complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    PTW/PP1 phosphatase complex IDA
    Inferred from Direct Assay
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		  
    glycogen granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein phosphatase type 1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase PP1-alpha catalytic subunit
    Names
    serine/threonine-protein phosphatase PP1-alpha catalytic subunit
    protein phosphatase 1, catalytic subunit, alpha isoform
    serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit
    NP_001008709.1
    NP_002699.1
    NP_996756.1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008709.1 → NP_001008709.1  serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also called PP-1 alpha 2) uses an alternate in-frame splice site at the 5' end of an exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is longer compared to isoform 1.
      Source sequence(s)
      AL557336, BC001888, BF526659, S57501
      Consensus CDS
      CCDS31618.1
      UniProtKB/Swiss-Prot
      P62136
      Related
      ENSP00000326031, OTTHUMP00000236398, ENST00000312989, OTTHUMT00000395484
      Conserved Domains (2) summary
      cd07414
      Location:8 – 311
      Blast Score: 1754
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
      PTZ00480
      Location:6 – 319
      Blast Score: 1421
      PTZ00480; serine/threonine-protein phosphatase; Provisional

    2. NM_002708.3 → NP_002699.1  serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
      Source sequence(s)
      BC001888, BC008010, BE793459, BM982080
      Consensus CDS
      CCDS8160.1
      UniProtKB/Swiss-Prot
      P62136
      Related
      ENSP00000365936, OTTHUMP00000236399, ENST00000376745, OTTHUMT00000395487
      Conserved Domains (2) summary
      cd07414
      Location:8 – 300
      Blast Score: 1772
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
      PTZ00480
      Location:6 – 308
      Blast Score: 1441
      PTZ00480; serine/threonine-protein phosphatase; Provisional

    3. NM_206873.1 → NP_996756.1  serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. The resulting isoform (2) lacks an internal region, as compared to isoform 1.
      Source sequence(s)
      BC008010, BE278068, BG480286, BM799599, BM982080
      Consensus CDS
      CCDS8161.1
      UniProtKB/TrEMBL
      A6NNR3
      UniProtKB/Swiss-Prot
      P62136
      Related
      ENSP00000350974, OTTHUMP00000236400, ENST00000358239, OTTHUMT00000395488
      Conserved Domains (2) summary
      cd07414
      Location:19 – 256
      Blast Score: 1496
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
      pfam00149
      Location:19 – 207
      Blast Score: 298
      Metallophos; Calcineurin-like phosphoesterase

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      67165652..67169376, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      63494035..63498137, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AP003419.3 (78644..82368) None
    genomic CH471076.1 EAW74607.1
      EAW74608.1
      EAW74609.1
      EAW74610.1
    mRNA AK098311.1 None
    mRNA AK127616.1 BAG54534.1
    mRNA AK313586.1 BAG36355.1
    mRNA AL557336.3 None
    mRNA BC001888.1 AAH01888.1
    mRNA BC004482.2 AAH04482.1
    mRNA BC008010.1 AAH08010.1
    mRNA BE278068.1 None
    mRNA BE793459.1 None
    mRNA BF526659.1 None
    mRNA BG480286.1 None
    mRNA BM799599.1 None
    mRNA BM982080.1 None
    mRNA BT006629.1 AAP35275.1
    mRNA J04759.1 AAA36475.1
    mRNA M63960.1 AAA36508.1
    mRNA S57501.1 AAB26015.1
    mRNA X70848.1 CAA50197.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62136.1 GenPept UniProtKB/Swiss-Prot:P62136
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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