ULK4 unc-51-like kinase 4 (C. elegans) [Homo sapiens] - Gene

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Summary

Official Symbol: ULK4provided by HGNC
Official Full Name: unc-51-like kinase 4 (C. elegans)provided by HGNC
Primary source: HGNC:15784
Locus tag: hCG_1996673
See related: Ensembl:ENSG00000168038; HPRD:07928; Vega:OTTHUMG00000156210
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FAM7C1; REC01035; FLJ20574; DKFZp434E1822

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Genomic context

Location :: 3p22.1

Sequence :: Chromosome: 3; NC_000003.11 (41288090..42003660, complement)

See ULK4 in Epigenomics, MapViewer

Chromosome 3 - NC_000003.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
Title: Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Recapitulation of two genomewide association studies on blood pressure and essential hypertension in the Korean population.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Genome-wide association study of blood pressure and hypertension.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide association study of blood pressure and hypertension.

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Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: serine/threonine-protein kinase ULK4

Names: serine/threonine-protein kinase ULK4

NP_060356.2

EC 2.7.11.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017886.2 → NP_060356.2 serine/threonine-protein kinase ULK4

Status: VALIDATED

Source sequence(s)

AK093396, AW504756, BC014794, BC018795, BF855180, BQ707161, BX096790, DC417397

Consensus CDS

CCDS43071.1

UniProtKB/TrEMBL

B3KSE5

UniProtKB/Swiss-Prot

Q96C45

Related

ENSP00000301831, OTTHUMP00000209481, ENST00000301831, OTTHUMT00000343490

Conserved Domains (4) summary

smart00220
Location:4 – 279
Blast Score: 545

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl02500
Location:646 – 756
Blast Score: 99

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

cl15759
Location:502 – 563
Blast Score: 91

Glyco_trans_4_4; Glycosyl transferase 4-like domain

cl09925
Location:8 – 279
Blast Score: 444

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000003.11 Reference GRCh37.p5 Primary Assembly

Range

41288090..42003660, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000135.1 Alternate HuRef

Range

41333321..42047163, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC097356.2 (40564..147266)	None
genomic	AC099059.2 (16256..158575)	None
genomic	AC099537.2 (11497..156511)	None
genomic	AC104305.2 (5846..149857)	None
genomic	AC104307.2 (91018..182638)	None
genomic	AC137935.2 (20164..105985)	None
genomic	CH471055.1	EAW64629.1
		EAW64630.1
		EAW64631.1
		EAW64632.1
		EAW64633.1
		EAW64634.1
		EAW64635.1
		EAW64636.1
genomic	CH471055.1	EAW64629.1
		EAW64630.1
		EAW64631.1
		EAW64632.1
		EAW64633.1
		EAW64634.1
		EAW64635.1
		EAW64636.1
mRNA	AK000581.1	BAA91270.1
mRNA	AK093396.1	BAG52707.1
mRNA	AK304341.1	BAG65186.1
mRNA	AL133104.1	CAB61411.1
mRNA	AW504756.1	None
mRNA	BC014794.1	AAH14794.1
mRNA	BC018795.1	None
mRNA	BC040739.1	AAH40739.1
mRNA	BF855180.1	None
mRNA	BQ707161.1	None
mRNA	BX096790.1	None
mRNA	DC417397.1	None
other-genetic	BC160098.1	AAI60098.1