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    BANP BTG3 associated nuclear protein [ Homo sapiens ]

    Gene ID: 54971, updated on 11-May-2012
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    Summary

    Official Symbol
    BANPprovided by HGNC
    Official Full Name
    BTG3 associated nuclear proteinprovided by HGNC
    Primary source
    HGNC:13450
    See related
    Ensembl:ENSG00000172530; HPRD:16538; MIM:611564; Vega:OTTHUMG00000137678
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BEND1; SMAR1; SMARBP1; FLJ10177; FLJ20538; DKFZp761H172
    Summary
    This gene encodes a protein that binds to matrix attachment regions. The protein forms a complex with p53 and negatively regulates p53 transcription, and functions as a tumor suppressor and cell cycle regulator. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
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    Genomic context

    Location :
    16q24
    Sequence :
    Chromosome: 16; NC_000016.9 (87985038..88110924)
    See BANP in Epigenomics, MapViewer

    Chromosome 16 - NC_000016.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506670 Neighboring gene solute carrier family 7 (amino acid transporter light chain, L system), member 5 Neighboring gene carbonic anhydrase VA, mitochondrial Neighboring gene uncharacterized LOC400553 Neighboring gene uncharacterized LOC100287221

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. New loci associated with central cornea thickness include COL5A1, AKAP13 and AVGR8. Vitart V, et al. Hum Mol Genet, 2010 Nov 1. PMID 20719862.
    2. Gene regulation by SMAR1: Role in cellular homeostasis and cancer. Malonia SK, et al. Biochim Biophys Acta, 2011 Jan. PMID 20709157.
    3. Network organization of the human autophagy system. Behrends C, et al. Nature, 2010 Jul 1. PMID 20562859.
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    5. Heat-shock protein 70 binds to a novel sequence in 5' UTR of tumor suppressor SMAR1 and regulates its mRNA stability upon Prostaglandin A2 treatment. Pavithra L, et al. FEBS Lett, 2010 Mar 19. PMID 20153327.

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. multiple roles of nuclear matrix associated protein SMAR1 in regulating various cellular target genes involved in cell growth, apoptosis and tumorigenesis.(REVIEW)
      Title: Gene regulation by SMAR1: Role in cellular homeostasis and cancer.
    2. A novel mechanism of regulation of oxidative stress by ATM through modulation of SMAR1-AKR1a4 complex, is proposed.
      Title: SMAR1 regulates free radical stress through modulation of AKR1a4 enzyme activity.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    4. SMAR1 plays a central role in coordinating p53 and TGFbeta pathways in human breast cancer.
      Title: p53 target gene SMAR1 is dysregulated in breast cancer: its role in cancer cell migration and invasion.
    5. report Prostaglandin A2 (PGA2) induced binding of HSP70 to a novel site on phi1 SMAR1 5' UTR which stabilizes the wild type transcript and leads to subsequent increase in SMAR1 protein levels.
      Title: Heat-shock protein 70 binds to a novel sequence in 5' UTR of tumor suppressor SMAR1 and regulates its mRNA stability upon Prostaglandin A2 treatment.
    6. On mild DNA damage, SMAR1 selectively represses BAX and PUMA through binding to the MAR independently of inducing p53 deacetylation through HDAC1.
      Title: Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element.
    7. Human breast cancer tissue sections that showed reduced SMAR1 expression exhibited increased surface roughness.
      Title: Tumor suppressor protein SMAR1 modulates the roughness of cell surface: combined AFM and SEM study.
    8. tumor suppressor SMAR1 downregulates Cytokeratin 8 gene expression by modulating p53-mediated transactivation of this gene
      Title: Tumor suppressor SMAR1 downregulates Cytokeratin 8 expression by displacing p53 from its cognate site.
    9. Results highlight the role of SMAR1 in masking the active phosphorylation site of p53, enabling the deacetylation of p53 by HDAC1-MDM2 complex, thereby regulating the p53 transcriptional response during stress rescue.
      Title: SMAR1 forms a ternary complex with p53-MDM2 and negatively regulates p53-mediated transcription.
    10. tumor suppressor protein SMAR1 can modulate NF-kappaB transactivation and inhibit tumorigenesis by regulating NF-kappaB target genes
      Title: Tumor suppressor SMAR1 represses IkappaBalpha expression and inhibits p65 transactivation through matrix attachment regions.
    Submit: New GeneRIF Correction See all (13)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Loci at chromosomes 13, 19 and 20 influence age at natural menopause.

    New loci associated with central cornea thickness include COL5A1, AKAP13 and AVGR8.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BTG3 associated nuclear protein Q14201 BTG3    HPRD  PubMed  
    BTG3 associated nuclear protein P04637 TP53    HPRD  PubMed  
    BTG3 associated nuclear protein Q12933 TRAF2    HPRD  PubMed  
    BioGRID:120308 BioGRID:109315 HDAC1    BioGRID  PubMed Co-localization 
    BioGRID:120308 BioGRID:109338 HIF1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120308 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:120308 BioGRID:110857 NFKB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120308 BioGRID:111384 PML    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:120308 BioGRID:111902 RELA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120308 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex 
    BioGRID:120308 BioGRID:113038 TRAF2    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    protein BANP
    Names
    protein BANP
    BEN domain-containing protein 1
    scaffold/matrix-associated region-1-binding protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029918.1 RefSeqGene

      Range
      5001..130887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001173539.1 → NP_001167010.1  protein BANP isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR, uses one alternate in-frame splices site, and lacks one alternate in-frame exon in the coding region, compared to variant 7. The resulting isoform (c) differs at two internal regions, compared to isoform g.
      Source sequence(s)
      AK001039, AK125232, AK293472, AL157429
      UniProtKB/TrEMBL
      B3KM38
      UniProtKB/TrEMBL
      B4DE54
      UniProtKB/Swiss-Prot
      Q8N9N5
      UniProtKB/TrEMBL
      Q9NSS6
      Conserved Domains (1) summary
      cl11158
      Location:257 – 330
      Blast Score: 208
      BEN; BEN domain

    2. NM_001173540.1 → NP_001167011.1  protein BANP isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter and 5' UTR, uses three alternate in-frame splices sites, and lacks one alternate in-frame exon in the coding region, compared to variant 7. The resulting isoform (d) differs at four internal regions, compared to isoform g.
      Source sequence(s)
      AK001039, AK125232, AK297945, AL157429
      Consensus CDS
      CCDS54055.1
      UniProtKB/TrEMBL
      B3KM38
      UniProtKB/Swiss-Prot
      Q8N9N5
      UniProtKB/TrEMBL
      Q9NSS6
      Related
      ENSP00000347290, ENST00000355163
      Conserved Domains (1) summary
      cl11158
      Location:224 – 297
      Blast Score: 209
      BEN; BEN domain

    3. NM_001173541.1 → NP_001167012.1  protein BANP isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) represents use of an alternate promoter and 5' UTR, uses one alternate in-frame splices site, and lacks two alternate in-frame exons in the coding region, compared to variant 7. The resulting isoform (e) differs at three internal regions, compared to isoform g.
      Source sequence(s)
      AK001039, AK297945, AK315089, AL157429
      Consensus CDS
      CCDS54053.1
      UniProtKB/TrEMBL
      B2RCF7
      UniProtKB/TrEMBL
      B3KM38
      UniProtKB/TrEMBL
      Q9NSS6
      Related
      ENSP00000432508, OTTHUMP00000233938, ENST00000479780, OTTHUMT00000390998
      Conserved Domains (1) summary
      cl11158
      Location:218 – 291
      Blast Score: 209
      BEN; BEN domain

    4. NM_001173542.1 → NP_001167013.1  protein BANP isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) represents use of an alternate promoter and 5' UTR, uses two alternate in-frame splices site, and lacks one alternate in-frame exon in the coding region, compared to variant 7. The resulting isoform (f) differs at three internal regions, compared to isoform g.
      Source sequence(s)
      AK293472, AK297945, AK315535, AL157429
      Consensus CDS
      CCDS54052.1
      UniProtKB/TrEMBL
      B4DE54
      UniProtKB/TrEMBL
      F5GZM0
      UniProtKB/TrEMBL
      Q9NSS6
      Related
      ENSP00000444352, ENST00000538234
      Conserved Domains (1) summary
      cl11158
      Location:257 – 330
      Blast Score: 208
      BEN; BEN domain

    5. NM_001173543.1 → NP_001167014.1  protein BANP isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) represents the longest transcript and encodes the longest isoform (g).
      Source sequence(s)
      AC127455, AK001039, AK094158, AK125232, AL157429
      Consensus CDS
      CCDS54054.1
      UniProtKB/TrEMBL
      B3KM38
      UniProtKB/Swiss-Prot
      Q8N9N5
      UniProtKB/TrEMBL
      Q9NSS6
      Related
      ENSP00000376902, OTTHUMP00000175042, ENST00000393207, OTTHUMT00000269166
      Conserved Domains (1) summary
      cl11158
      Location:249 – 322
      Blast Score: 208
      BEN; BEN domain

    6. NM_017869.3 → NP_060339.2  protein BANP isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents use of an alternate promoter and 5' UTR, uses two alternate in-frame splices sites, and lacks two alternate in-frame exons in the coding region, compared to variant 7. The resulting isoform (a) differs at four internal regions, compared to isoform g.
      Source sequence(s)
      AK000545, AK001039, AL157429, BC009424, CN289917, DA632793, T49823
      Consensus CDS
      CCDS42215.1
      UniProtKB/TrEMBL
      B3KM38
      UniProtKB/Swiss-Prot
      Q8N9N5
      UniProtKB/TrEMBL
      Q9NSS6
      Related
      ENSP00000347125, OTTHUMP00000175043, ENST00000355022, OTTHUMT00000269167
      Conserved Domains (1) summary
      cl11158
      Location:218 – 291
      Blast Score: 209
      BEN; BEN domain

    7. NM_079837.2 → NP_524576.2  protein BANP isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, uses two alternate in-frame splices sites, and lacks one alternate in-frame exon in the coding region, compared to variant 7. The resulting isoform (b) differs at three internal regions, compared to isoform g.
      Source sequence(s)
      AK001039, AK125232, AL157429, CN289917, DA632793
      Consensus CDS
      CCDS10966.2
      UniProtKB/TrEMBL
      B3KM38
      UniProtKB/Swiss-Prot
      Q8N9N5
      UniProtKB/TrEMBL
      Q9NSS6
      Related
      ENSP00000376903, OTTHUMP00000175041, ENST00000393208, OTTHUMT00000269165
      Conserved Domains (1) summary
      cl11158
      Location:218 – 291
      Blast Score: 209
      BEN; BEN domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000016.9 Reference GRCh37.p5 Primary Assembly

      Range
      87985038..88110924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000148.1 Alternate HuRef

      Range
      73724801..73847588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC127455.4 (95251..142347) None
    genomic AC134312.3 (587..79373) None
    genomic CH471114.2 EAW95364.1
      EAW95365.1
      EAW95366.1
      EAW95367.1
      EAW95368.1
      EAW95369.1
      EAW95370.1
    mRNA AK001039.1 BAG50850.1
    mRNA AK094158.1 BAC04296.1
    mRNA AK125232.1 BAG54171.1
    mRNA AK293472.1 BAG56965.1
    mRNA AK297945.1 BAG60261.1
    mRNA AK315089.1 BAG37554.1
    mRNA AK315535.1 None
    mRNA AL157429.1 CAB75653.1
    mRNA BC009424.1 AAH09424.1
    mRNA BC018247.1 None
    mRNA CN289917.1 None
    mRNA DA632793.1 None
    mRNA T49823.1 None
    other-genetic DQ893176.2 ABM84102.1
    other-genetic DQ896475.2 ABM87474.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N9N5.3 GenPept UniProtKB/Swiss-Prot:Q8N9N5
    Q9NSS6 GenPept UniProtKB/TrEMBL:Q9NSS6
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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