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    RNF125 ring finger protein 125, E3 ubiquitin protein ligase [ Homo sapiens ]

    Gene ID: 54941, updated on 11-May-2012
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    Summary

    Official Symbol
    RNF125provided by HGNC
    Official Full Name
    ring finger protein 125, E3 ubiquitin protein ligaseprovided by HGNC
    Primary source
    HGNC:21150
    See related
    Ensembl:ENSG00000101695; HPRD:11500; MIM:610432; Vega:OTTHUMG00000132266
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRAC1; TRAC-1; FLJ20456; MGC21737
    Summary
    This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. [provided by RefSeq, Mar 2012]
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    Genomic context

    Location :
    18q12.1
    Sequence :
    Chromosome: 18; NC_000018.9 (29598445..29653154)
    See RNF125 in Epigenomics, MapViewer

    Chromosome 18 - NC_000018.9Genomic Context describing neighboring genes Neighboring gene epsin 2 pseudogene Neighboring gene phosphogluconate dehydrogenase pseudogene 1 Neighboring gene ribosomal protein S15a pseudogene 35 Neighboring gene ring finger protein 138, E3 ubiquitin protein ligase

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. Markson G, et al. Genome Res, 2009 Oct. PMID 19549727.
    3. T-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domain. Giannini AL, et al. Biochem J, 2008 Feb 15. PMID 17990982.
    4. UbcH8 regulates ubiquitin and ISG15 conjugation to RIG-I. Arimoto K, et al. Mol Immunol, 2008 Feb. PMID 17719635.
    5. The RING finger ubiquitin ligase RNF125/TRAC-1 down-modulates HIV-1 replication in primary human peripheral blood mononuclear cells. Shoji-Kawata S, et al. Virology, 2007 Nov 10. PMID 17643463.

    See all (13) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. TRAC-1 associates with membranes and is excluded from the nucleus through myristoylation
      Title: T-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domain.
    2. These results suggest that RNF125/TRAC-1 could function to recruit host factor(s) controlling HIV-1 transcription to the ubiquitin-proteasome pathway.
      Title: The RING finger ubiquitin ligase RNF125/TRAC-1 down-modulates HIV-1 replication in primary human peripheral blood mononuclear cells.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:120281 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:120281 BioGRID:113169 UBE2D1    BioGRID  PubMed Two-hybrid 
    BioGRID:120281 BioGRID:113170 UBE2D2    BioGRID  PubMed Two-hybrid 
    BioGRID:120281 BioGRID:113171 UBE2D3    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:120281 BioGRID:119641 UBE2D4    BioGRID  PubMed Two-hybrid 
    BioGRID:120281 BioGRID:113173 UBE2E2    BioGRID  PubMed Two-hybrid 
    BioGRID:120281 BioGRID:109340 UBE2K    BioGRID  PubMed Two-hybrid 
    BioGRID:120281 BioGRID:113180 UBE2L3    BioGRID  PubMed Two-hybrid 
    BioGRID:120281 BioGRID:114672 UBE2L6    BioGRID  PubMed Two-hybrid 
    BioGRID:120281 BioGRID:113182 UBE2N    BioGRID  PubMed Two-hybrid 
    BioGRID:120281 BioGRID:127156 UBE2U    BioGRID  PubMed Two-hybrid 
    BioGRID:120281 BioGRID:120572 UBE2W    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystem (from REACTOME)
      Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystemAs with other cytokine systems, production of type I IFN is a transient process, and can be hazardous to the host if unregulated, resulting in chronic cellular toxicity or inflammatory and autoimmune...
    • RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
      RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemRIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm. F...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    ubiquitin-protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    innate immune response TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of type I interferon production TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF125
    Names
    E3 ubiquitin-protein ligase RNF125
    T-cell RING activation protein 1
    T-cell ring protein identified in activation screen
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017831.3 → NP_060301.2  E3 ubiquitin-protein ligase RNF125

      Status: REVIEWED

      Source sequence(s)
      AC011825, AK000463, BC012021, BI666910
      Consensus CDS
      CCDS11902.1
      UniProtKB/Swiss-Prot
      Q96EQ8
      Related
      ENSP00000217740, OTTHUMP00000163102, ENST00000217740, OTTHUMT00000255354
      Conserved Domains (2) summary
      cd00162
      Location:36 – 77
      Blast Score: 111
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam13923
      Location:33 – 77
      Blast Score: 100
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000018.9 Reference GRCh37.p5 Primary Assembly

      Range
      29598445..29653154
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000150.1 Alternate HuRef

      Range
      26455131..26510081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC009831.21 (130040..179408) None
    genomic AC011825.13 (26505..31846) None
    genomic CH471088.1 EAX01278.1
    mRNA AK000463.1 BAA91182.1
    mRNA AK027134.1 None
    mRNA AK225518.1 None
    mRNA BC012021.1 AAH12021.1
    mRNA BI666910.1 None
    mRNA BM469263.1 None
    mRNA BU500546.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96EQ8.4 GenPept UniProtKB/Swiss-Prot:Q96EQ8
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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