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CYP2W1 cytochrome P450 family 2 subfamily W member 1 [ Homo sapiens (human) ]

Gene ID: 54905, updated on 8-May-2016
Official Symbol
CYP2W1provided by HGNC
Official Full Name
cytochrome P450 family 2 subfamily W member 1provided by HGNC
Primary source
HGNC:HGNC:20243
See related
Ensembl:ENSG00000073067 HPRD:07901; MIM:615967; Vega:OTTHUMG00000074071
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. [provided by RefSeq, Jul 2008]
Orthologs
Location:
7p22.3
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (983156..989640)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (1020100..1029276)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ArfGAP with dual PH domains 1 Neighboring gene COX19 cytochrome c oxidase assembly factor Neighboring gene chromosome 7 open reading frame 50 Neighboring gene microRNA 339 Neighboring gene G protein-coupled receptor 146

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
NHGRI GWA Catalog
  • Biological oxidations, organism-specific biosystem (from REACTOME)
    Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
  • Cytochrome P450 - arranged by substrate type, organism-specific biosystem (from REACTOME)
    Cytochrome P450 - arranged by substrate type, organism-specific biosystemThe P450 isozyme system is the major phase 1 biotransforming system in man, accounting for more than 90% of drug biotransformations. This system has huge catalytic versatility and a broad substrate s...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Miscellaneous substrates, organism-specific biosystem (from REACTOME)
    Miscellaneous substrates, organism-specific biosystemApproximately a quarter of the 57 human CYPs still remain "orphans" in the sense that their function, expression sites, and regulation are largely not elucidated. While there is enough experimental e...
  • Phase 1 - Functionalization of compounds, organism-specific biosystem (from REACTOME)
    Phase 1 - Functionalization of compounds, organism-specific biosystemPhase 1 of metabolism is concerned with functionalization, that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conj...
  • Xenobiotics, organism-specific biosystem (from REACTOME)
    Xenobiotics, organism-specific biosystemOf the 50 microsomal CYPs, 15 act on xenobiotics. They all possess wide substrate specificity to cater for most foreign compounds that find their way into the body.
  • cytochrome P450, organism-specific biosystem (from WikiPathways)
    cytochrome P450, organism-specific biosystemOxidation of a substrate by Cytochrome P450. Adapted from Niesink et al., Chapter 3, p. 47-48.
  • metapathway biotransformation, organism-specific biosystem (from WikiPathways)
    metapathway biotransformation, organism-specific biosystem
    metapathway biotransformation
Products Interactant Other Gene Complex Source Pubs Description

Homology

Clone Names

  • MGC34287

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heme binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity TAS
Traceable Author Statement
more info
 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
steroid hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
aflatoxin B1 metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
cytochrome P450 2W1
Names
CYPIIW1
cytochrome P450, family 2, subfamily W, polypeptide 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007934.1 RefSeqGene

    Range
    5001..11442
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_017781.2NP_060251.2  cytochrome P450 2W1 precursor

    See identical proteins and their annotated locations for NP_060251.2

    Status: REVIEWED

    Source sequence(s)
    BC025761
    Consensus CDS
    CCDS5319.2
    UniProtKB/Swiss-Prot
    Q8TAV3
    Related
    ENSP00000310149, OTTHUMP00000082705, ENST00000308919, OTTHUMT00000157249
    Conserved Domains (1) summary
    pfam00067
    Location:32479
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

    Range
    983156..989640
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515441.1XP_011513743.1  

    Conserved Domains (1) summary
    pfam00067
    Location:32462
    p450; Cytochrome P450
  2. XM_011515440.1XP_011513742.1  

    Conserved Domains (1) summary
    pfam00067
    Location:32452
    p450; Cytochrome P450

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    1021926..1028345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)