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ELOVL2 ELOVL fatty acid elongase 2 [ Homo sapiens (human) ]

Gene ID: 54898, updated on 8-May-2016
Official Symbol
ELOVL2provided by HGNC
Official Full Name
ELOVL fatty acid elongase 2provided by HGNC
Primary source
HGNC:HGNC:14416
See related
Ensembl:ENSG00000197977 HPRD:16857; MIM:611814; Vega:OTTHUMG00000014252
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SSC2
Orthologs
Location:
6p24.2
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (10980759..11044391, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (10980992..11044624, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene glial cells missing homolog 2 Neighboring gene synaptonemal complex protein 2 like Neighboring gene uncharacterized LOC101928191 Neighboring gene siah E3 ubiquitin protein ligase family member 3 pseudogene Neighboring gene ELOVL2 antisense RNA 1 Neighboring gene endogenous retrovirus group FRD member 1 Neighboring gene small integral membrane protein 13 Neighboring gene uncharacterized LOC105374926 Neighboring gene neural precursor cell expressed, developmentally down-regulated 9

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
NHGRI GWA Catalog
Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.
NHGRI GWA Catalog
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
NHGRI GWA Catalog
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
NHGRI GWA Catalog
Human metabolic individuality in biomedical and pharmaceutical research.
NHGRI GWA Catalog
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of ELOVL fatty acid elongase 2 (ELOVL2) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ20334

Gene Ontology Provided by GOA

Function Evidence Code Pubs
fatty acid elongase activity EXP
Inferred from Experiment
more info
PubMed 
fatty acid elongase activity IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid elongase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
elongation of very long chain fatty acids protein 2
Names
3-keto acyl-CoA synthase ELOVL2
ELOVL FA elongase 2
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2
very long chain 3-ketoacyl-CoA synthase 2
very long chain 3-oxoacyl-CoA synthase 2
very-long-chain 3-oxoacyl-CoA synthase 2
NP_060240.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017770.3NP_060240.3  elongation of very long chain fatty acids protein 2

    See identical proteins and their annotated locations for NP_060240.3

    Status: VALIDATED

    Source sequence(s)
    AK000341, AL080199, AL121955, BC050278
    Consensus CDS
    CCDS4518.1
    UniProtKB/Swiss-Prot
    Q9NXB9
    UniProtKB/TrEMBL
    A0A024QZV3
    Related
    ENSP00000346693, OTTHUMP00000016029, ENST00000354666, OTTHUMT00000039849
    Conserved Domains (1) summary
    pfam01151
    Location:30264
    ELO; GNS1/SUR4 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    10980759..11044391 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514717.1XP_011513019.1  

    UniProtKB/Swiss-Prot
    Q9NXB9
    Conserved Domains (1) summary
    pfam01151
    Location:31265
    ELO; GNS1/SUR4 family
  2. XM_011514716.1XP_011513018.1  

    Conserved Domains (1) summary
    pfam01151
    Location:60294
    ELO; GNS1/SUR4 family

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    10983093..11046725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)