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ALKBH5 alkB homolog 5, RNA demethylase [ Homo sapiens (human) ]

Gene ID: 54890, updated on 8-May-2016
Official Symbol
ALKBH5provided by HGNC
Official Full Name
alkB homolog 5, RNA demethylaseprovided by HGNC
Primary source
HGNC:HGNC:25996
See related
Ensembl:ENSG00000091542 HPRD:08621; MIM:613303; Vega:OTTHUMG00000059397
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ABH5; OFOXD; OFOXD1
Orthologs
Location:
17p11.2; 17p11.2
Exon count:
4
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (18183553..18209954)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (18086867..18113268)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371566 Neighboring gene developmentally regulated GTP binding protein 2 Neighboring gene myosin XVA Neighboring gene uncharacterized LOC105371568 Neighboring gene LLGL1, scribble cell polarity complex component Neighboring gene FLII, actin remodeling protein Neighboring gene mitochondrial elongation factor 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ20308

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidative single-stranded RNA demethylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
xenophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
RNA demethylase ALKBH5
Names
AlkB family member 5, RNA demethylase
alkB, alkylation repair homolog 5
alkylated DNA repair protein alkB homolog 5
alpha-ketoglutarate-dependent dioxygenase alkB homolog 5
oxoglutarate and iron-dependent oxygenase domain containing
probable alpha-ketoglutarate-dependent dioxygenase ABH5
NP_060228.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017758.3NP_060228.3  RNA demethylase ALKBH5

    See identical proteins and their annotated locations for NP_060228.3

    Status: VALIDATED

    Source sequence(s)
    AK000315, BC062339, BI823385, BU740432
    Consensus CDS
    CCDS42272.1
    UniProtKB/Swiss-Prot
    Q6P6C2
    Related
    ENSP00000382091, OTTHUMP00000065701, ENST00000399138, OTTHUMT00000132069
    Conserved Domains (1) summary
    cl21496
    Location:136270
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    18183553..18209954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    18095612..18122007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)