APTX aprataxin [Homo sapiens] - Gene

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Summary

Official Symbol: APTXprovided by HGNC
Official Full Name: aprataxinprovided by HGNC
Primary source: HGNC:15984
Locus tag: RP11-562M8.1
See related: Ensembl:ENSG00000137074; HPRD:05892; MIM:606350; Vega:OTTHUMG00000019759
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AOA; AOA1; AXA1; EAOH; EOAHA; FHA-HIT; MGC1072; FLJ20157
Summary: This gene encodes a member of the histidine triad (HIT) superfamily. The encoded protein may play a role in single-stranded DNA repair through its nucleotide-binding activity and its diadenosine polyphosphate hydrolase activity. Mutations in this gene have been associated with ataxia-ocular apraxia. Alternatively spliced transcript variants have been identified for this gene.[provided by RefSeq, Aug 2010]

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Genomic context

Location :: 9p13.3

Sequence :: Chromosome: 9; NC_000009.11 (32972604..33001639, complement)

See APTX in Epigenomics, MapViewer

Chromosome 9 - NC_000009.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that mutations affecting protein folding, the active site pocket and the pivot motif underlie aprataxin dysfunction in the neurodegenerative disorder ataxia with oculomotor apraxia 1 (AOA1).
Title: Structure of an aprataxin-DNA complex with insights into AOA1 neurodegenerative disease.
The clinical phenotype was homogeneous, irrespectively of the type and location of the APTX mutation, and it was mainly characterized by early-onset cerebellar signs, sensory neuropathy, cognitive decline, and oculomotor deficits.
Title: Ataxia with oculomotor apraxia type1 (AOA1): novel and recurrent aprataxin mutations, coenzyme Q10 analyses, and clinical findings in Italian patients.
The patients with early onset ataxia with ocular motor apraxia and hypoalbuminaemia homozygous for the c.689_690insT mutation(APTX) show a more severe phenotype than those with a p.Pro206Leu or p.Val263Gly mutation.
Title: Genotype-phenotype correlations in early onset ataxia with ocular motor apraxia and hypoalbuminaemia.
Aprataxin is required for the normal repair rate of DNA single-strand breaks induced by genotoxic agents.
Title: A novel nonsense mutation in the APTX gene associated with delayed DNA single-strand break removal fails to enhance sensitivity to different genotoxic agents.
Aprataxin localizes to mitochondria and preserves mitochondrial function.
Title: Aprataxin localizes to mitochondria and preserves mitochondrial function.
Loss of HNT3 in rad27Delta cells, which are deficient in long-patch base excision repair (LP-BER), resulted in synergistic sensitivity to H(2)O(2) and methylmethane sulfonate.
Title: Genetic interactions between HNT3/Aprataxin and RAD27/FEN1 suggest parallel pathways for 5' end processing during base excision repair.
searched for aprataxin mutations in Greek patients with sporadic cerebellar ataxia where GAA expansion in frataxin gene has been excluded; no detectable point mutation or deletion was found in the aprataxin gene of all the patients
Title: Absence of aprataxin gene mutations in a Greek cohort with sporadic early onset ataxia and normal GAA triplets in frataxin gene.
High aprataxin levels are associated with low irinotecan response in colorectal cancer.
Title: Aprataxin tumor levels predict response of colorectal cancer patients to irinotecan-based treatment.
Data demonstrate the presence of elevated levels of oxidative DNA damage in AOA1 cells coupled with reduced base excision and gap filling repair efficiencies indicative of a synergy between aprataxin, PARP-1, APE-1 and OGG1 in the DNA damage response.
Title: Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage.
Data show that the RASGRP1/APTX gene expression ratio was higher in the responder while the AKAP13 expression was higher in the non-responders.
Title: Phase II trial and prediction of response of single agent tipifarnib in patients with relapsed/refractory mantle cell lymphoma: a Groupe d'Etude des Lymphomes de l'Adulte trial.

Submit: New GeneRIF Correction See all (33)

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Phenotypes

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia

MIM: 208920

Ataxia with oculomotor apraxia type 1 (AOA1) is characterized by childhood onset of slowly progressive cerebellar ataxia, followed by oculomotor apraxia and a severe primary motor peripheral axonal motor neuropathy. The first manifestation is progressive gait imbalance (mean age of onset: 4.3 years; range: 2-10 years), followed by dysarthria, then upper-limb dysmetria with mild intention tremor. Oculomotor apraxia, usually noticed a few years after the onset of ataxia, progresses to external ophthalmoplegia. All affected individuals have generalized areflexia followed by a peripheral neuropathy and quadriplegia with loss of ambulation about seven to ten years after onset. Hands and feet are short and atrophic. Chorea and upper-limb dystonia are common. Intellect remains normal in some individuals; in others, different degrees of cognitive impairment have been observed.

Diagnosis Testing

The diagnosis of AOA1 is based on clinical findings (including family history) and exclusion of the diagnosis of ataxia-telangiectasia. Cerebellar atrophy is visible on MRI in all affected individuals. EMG reveals axonal neuropathy in 100% of individuals with AOA1. Molecular genetic testing of APTX, the only gene associated with AOA1, is clinically available.

Genetic Counseling

AOA1 is inherited in an autosomal recessive manner. At conception, each sib of an affected individual has a 25% chance of being affected, a 50% chance of being an asymptomatic carrier, and a 25% chance of being neither affected nor a carrier. Carrier testing for at-risk family members and prenatal testing for pregnancies at increased risk are possible if both the disease-causing alleles in a family are known.

References

PMID: 20301629

Coenzyme Q10 deficiency

MIM: 607426

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
NP_778243.1	NP_006288.1	XRCC1	BIND	PubMed	APTX interacts with XRCC1.
Q7Z2E3	Calcium binding and coiled-coil domain 1	CALCOCO1	HPRD	PubMed
Q7Z2E3	Q5VT06	CEP350	HPRD	PubMed
Q7Z2E3	Q8N137	CNTROB	HPRD	PubMed
Q7Z2E3	P15822	HIVEP1	HPRD	PubMed
Q7Z2E3	Mitogen activated protein kinase binding protein 1 like	MAPKBP1	HPRD	PubMed
Q7Z2E3	P02686	MBP	HPRD	PubMed
Q7Z2E3	P09874	PARP1	HPRD	PubMed
Q7Z2E3	Q9NRD5	PICK1	HPRD	PubMed
Q7Z2E3	Synaptotagmin XVII	SYT17	HPRD	PubMed
Q7Z2E3	O94972	TRIM37	HPRD	PubMed
Q7Z2E3	Cell division autoantigen 1	TSPYL2	HPRD	PubMed
Q7Z2E3	P18887	XRCC1	HPRD	PubMed
Q7Z2E3	Q13426	XRCC4	HPRD	PubMed
Q7Z2E3	Q9UID6	ZNF639	HPRD	PubMed
BioGRID:120191	BioGRID:114342	BANF1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120191	BioGRID:106652	PARP1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:120191	BioGRID:113010	TP53	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:120191	BioGRID:113349	XRCC1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid

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General gene information

Markers

RH46890 (e-PCR)
- UniSTS:39445

G20636 (e-PCR)
- UniSTS:62782

A005Z44 (e-PCR)
- UniSTS:62783

RH16252 (e-PCR)
- UniSTS:28030

G32803 (e-PCR)
- UniSTS:117382

AB056422 (e-PCR)
- UniSTS:480150

SHGC-148705 (e-PCR)
- UniSTS:176568

SHGC-34030 (e-PCR)
- UniSTS:55738

NoName (e-PCR)
- UniSTS:488157

A009S13 (e-PCR)
- UniSTS:15852

Genotypes

See APTX SNP Geneview Report
See APTX SNP Genotype Report
See APTX SNP Variation Viewer Report

Homology

Map Viewer (Mouse, Rat)

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
DNA 5'-adenosine monophosphate hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
catalytic activity	IEA Inferred from Electronic Annotation more info
chromatin binding	IDA Inferred from Direct Assay more info	PubMed
damaged DNA binding	IDA Inferred from Direct Assay more info	PubMed
double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
double-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed
hydrolase activity	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
phosphoglycolate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
phosphoprotein binding	IPI Inferred from Physical Interaction more info
polynucleotide 3'-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
protein N-terminus binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
cell death	IEA Inferred from Electronic Annotation more info
double-strand break repair	IDA Inferred from Direct Assay more info	PubMed
regulation of protein stability	IMP Inferred from Mutant Phenotype more info	PubMed
response to DNA damage stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
response to hydrogen peroxide	IDA Inferred from Direct Assay more info	PubMed
single strand break repair	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
chromatin	IDA Inferred from Direct Assay more info	PubMed
intracellular	IEA Inferred from Electronic Annotation more info
colocalizes_with nuclear chromatin	IDA Inferred from Direct Assay more info
nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info

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General protein information

Preferred Names: aprataxin

Names: aprataxin; forkhead-associated domain histidine triad-like protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012821.1 RefSeqGene

Range

4988..34023

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001195248.1 → NP_001182177.1 aprataxin isoform e

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks an exon in the 5' UTR compared to variant 1. This results in translation initiation at an upstream ATG and an isoform (e) with a longer N-terminus compared to isoform a.

Source sequence(s)

AA494365, AL353717, AY040777, AY208830

UniProtKB/Swiss-Prot

Q7Z2E3

Related

ENSP00000369147, OTTHUMP00000021190, ENST00000379819, OTTHUMT00000052028

Conserved Domains (2) summary

cd00060
Location:20 – 113
Blast Score: 108

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01278
Location:178 – 279
Blast Score: 365

aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...
NM_001195249.1 → NP_001182178.1 aprataxin isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1 and 7 encode the same isoform (a).

Source sequence(s)

AA494365, AL353717, AY208836, DA664623

Consensus CDS

CCDS47956.1

UniProtKB/TrEMBL

Q6JV85

UniProtKB/Swiss-Prot

Q7Z2E3

Related

ENSP00000369141, ENST00000379813

Conserved Domains (2) summary

cd00060
Location:6 – 99
Blast Score: 108

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01278
Location:164 – 265
Blast Score: 363

aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...
NM_001195250.1 → NP_001182179.1 aprataxin isoform f

Status: REVIEWED

Description

Transcript Variant: This variant (8) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform f, which is shorter than isoform a.

Source sequence(s)

AA494365, AL353717, AY208830

Consensus CDS

CCDS56568.1

UniProtKB/Swiss-Prot

Q7Z2E3

Related

ENSP00000419042, OTTHUMP00000215291, ENST00000476858, OTTHUMT00000355312

Conserved Domains (2) summary

cd01278
Location:124 – 225
Blast Score: 362

aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...

TIGR01663
Location:14 – 58
Blast Score: 87

PNK-3'Pase; polynucleotide 5'-kinase 3'-phosphatase
NM_001195251.1 → NP_001182180.1 aprataxin isoform g

Status: REVIEWED

Description

Transcript Variant: This variant (9) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. This variant encodes isoform g, which has a shorter and distinct C-terminus, compared to isoform a.

Source sequence(s)

AA494365, AY208830, BX538161

UniProtKB/Swiss-Prot

Q7Z2E3

Conserved Domains (2) summary

cd00060
Location:6 – 99
Blast Score: 108

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01278
Location:164 – 265
Blast Score: 365

aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...
NM_001195252.1 → NP_001182181.1 aprataxin isoform i

Status: REVIEWED

Description

Transcript Variant: This variant (11) has multiple differences compared to variant 1. These differences result in translation initiation at an upstream ATG and an isoform (i) with a longer N-terminus but an overall shorter length compared to isoform a.

Source sequence(s)

AA494365, AY208830, AY208831

UniProtKB/Swiss-Prot

Q7Z2E3

Related

ENSP00000380357, OTTHUMP00000215305, ENST00000397172, OTTHUMT00000355327

Conserved Domains (2) summary

cd01278
Location:106 – 207
Blast Score: 357

aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...

cl00062
Location:20 – 103
Blast Score: 97

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
NM_001195254.1 → NP_001182183.1 aprataxin isoform h

Status: REVIEWED

Description

Transcript Variant: This variant (10) differs in the 5' UTR and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform h, which is shorter than isoform a.

Source sequence(s)

AA494365, AL353717, AY208833, DB042208

UniProtKB/Swiss-Prot

Q7Z2E3

Related

ENSP00000417649, OTTHUMP00000215307, ENST00000477119, OTTHUMT00000355332

Conserved Domains (2) summary

cd01278
Location:110 – 211
Blast Score: 360

aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...

TIGR01663
Location:3 – 44
Blast Score: 85

PNK-3'Pase; polynucleotide 5'-kinase 3'-phosphatase
NM_175069.2 → NP_778239.1 aprataxin isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) has multiple differences compared to variant 1. These differences result in translation initiation at an upstream ATG and an isoform (b) with a longer N-terminus and a shorter C-terminus compared to isoform a.

Source sequence(s)

AA494365, AK055672, AY208830

Consensus CDS

CCDS6532.1

UniProtKB/Swiss-Prot

Q7Z2E3

Related

ENSP00000311547, ENST00000309615

Conserved Domains (2) summary

cd00060
Location:20 – 113
Blast Score: 107

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01278
Location:178 – 279
Blast Score: 367

aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...
NM_175073.2 → NP_778243.1 aprataxin isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform a. Variants 1 and 7 encode the same isoform (a).

Source sequence(s)

AA494365, AL353717, AY208830, AY208837

Consensus CDS

CCDS47956.1

UniProtKB/TrEMBL

Q6JV85

UniProtKB/Swiss-Prot

Q7Z2E3

Related

ENSP00000420263, OTTHUMP00000215302, ENST00000468275, OTTHUMT00000355323

Conserved Domains (2) summary

cd00060
Location:6 – 99
Blast Score: 108

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01278
Location:164 – 265
Blast Score: 363

aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...

RNA

NR_036576.1 RNA Sequence

Description

Transcript Variant: This variant (12) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AA494365, AL353717, AY208830, AY208840
NR_036577.1 RNA Sequence

Description

Transcript Variant: This variant (13) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AA494365, AL353717, AY208830, BC001628
NR_036578.1 RNA Sequence

Description

Transcript Variant: This variant (14) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AA494365, AL353717, AY208835, DB042208
NR_036579.1 RNA Sequence

Description

Transcript Variant: This variant (15) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 7, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AA494365, AL353717, AY208839, DA664623

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000009.11 Reference GRCh37.p5 Primary Assembly

Range

32972604..33001639, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000141.1 Alternate HuRef

Range

32930986..32960001, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_017692.2: Suppressed sequence

Description

NM_017692.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
NM_175072.1: Suppressed sequence

Description

NM_175072.1: This RefSeq was permanently suppressed because the transcript is likely partial.

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL162590.15	CAI15549.1
		CAI15550.1
		CAI15551.1
genomic	AL353717.13	CAI15728.1
		CAI15729.1
		CAI15730.1
		CAI15734.1
		CAI15735.1
genomic	CH471071.2	EAW58528.1
		EAW58529.1
		EAW58530.1
		EAW58531.1
		EAW58532.1
		EAW58533.1
		EAW58534.1
		EAW58535.1
genomic	CS185575.1	CAJ42756.1
mRNA	AA494365.1	None
mRNA	AB603741.1	BAK31015.1
mRNA	AJ565850.1	CAD92454.1
mRNA	AJ565851.1	CAD92455.1
mRNA	AJ565852.1	CAD92456.1
mRNA	AJ565853.1	CAD92457.1
mRNA	AJ565854.1	CAD92458.1
mRNA	AJ565855.1	CAD92459.1
mRNA	AJ575566.1	CAE01427.1
mRNA	AK000164.1	BAA90985.1
mRNA	AK055672.1	BAG51552.1
mRNA	AK131046.1	None
mRNA	AY040777.1	AAK91768.1
mRNA	AY208829.1	AAP86319.1
mRNA	AY208830.1	AAP86320.1
mRNA	AY208831.1	AAP86321.1
mRNA	AY208832.1	AAP86322.1
mRNA	AY208833.1	AAP86323.1
mRNA	AY208834.1	AAP86324.1
mRNA	AY208835.1	AAP86325.1
mRNA	AY208836.1	AAP86326.1
mRNA	AY208837.1	AAP86327.1
mRNA	AY208838.1	AAP86328.1
mRNA	AY208839.1	AAP86329.1
mRNA	AY208840.1	AAP86330.1
mRNA	AY208841.1	AAP86331.1
mRNA	AY208842.1	AAP86332.1
mRNA	AY302067.1	AAQ74130.1
mRNA	AY302068.1	AAQ74131.1
mRNA	AY302069.1	AAQ74132.1
mRNA	AY302070.1	AAQ74133.1
mRNA	AY302071.1	AAQ74134.1
mRNA	AY302072.1	AAQ74135.1
mRNA	AY302073.1	AAQ74136.1
mRNA	AY302074.1	AAQ74137.1
mRNA	BC001628.1	AAH01628.1
mRNA	BC032650.1	AAH32650.1
mRNA	BC068107.1	None
mRNA	BC104881.1	AAI04882.1
mRNA	BQ957536.1	None
mRNA	BX538161.1	CAD98041.1
mRNA	CA429601.1	None
mRNA	DA664623.1	None
mRNA	DB042208.1	None
other-genetic	JF432548.1	ADZ15765.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q5T783	GenPept	UniProtKB/TrEMBL:Q5T783
Q6JV79	GenPept	UniProtKB/TrEMBL:Q6JV79
Q6JV81	GenPept	UniProtKB/TrEMBL:Q6JV81
Q6JV82	GenPept	UniProtKB/TrEMBL:Q6JV82
Q6JV85	GenPept	UniProtKB/TrEMBL:Q6JV85
Q7Z2E3.2	GenPept	UniProtKB/Swiss-Prot:Q7Z2E3