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    BTG4 B-cell translocation gene 4 [ Homo sapiens ]

    Gene ID: 54766, updated on 11-May-2012
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    Summary

    Official Symbol
    BTG4provided by HGNC
    Official Full Name
    B-cell translocation gene 4provided by HGNC
    Primary source
    HGNC:13862
    See related
    Ensembl:ENSG00000137707; HPRD:16138; MIM:605673; Vega:OTTHUMG00000166718
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PC3B; MGC33003
    Summary
    The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein can induce G1 arrest in the cell cycle. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    11q23
    Sequence :
    Chromosome: 11; NC_000011.9 (111338255..111383064, complement)
    See BTG4 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene POU class 2 associating factor 1 Neighboring gene uncharacterized LOC644277 Neighboring gene uncharacterized LOC100506852 Neighboring gene uncharacterized LOC728196 Neighboring gene microRNA 34b Neighboring gene microRNA 34c

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocellular carcinoma. Xu Y, et al. Int J Cancer, 2011 Jan 15. PMID 20309940.
    2. Frequent promoter hypermethylation and transcriptional downregulation of BTG4 gene in gastric cancer. Dong W, et al. Biochem Biophys Res Commun, 2009 Sep 11. PMID 19576178.
    3. Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. Toyota M, et al. Cancer Res, 2008 Jun 1. PMID 18519671.
    4. NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase. Fortier JM, et al. J Immunol, 2006 Jun 1. PMID 16709802.
    5. Identification of a potential role for POU2AF1 and BTG4 in the deletion of 11q23 in chronic lymphocytic leukemia. Auer RL, et al. Genes Chromosomes Cancer, 2005 May. PMID 15672409.

    See all (9) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
      Title: A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocellular carcinoma.
    2. these data support BTG4 as a candidate tumor suppressor gene that is epigenetically silenced in the majority of gastric cancers.
      Title: Frequent promoter hypermethylation and transcriptional downregulation of BTG4 gene in gastric cancer.
    3. miR-34b/c and BTG4 are novel tumor suppressors in colorectal cancer (CRC) and that the miR-34b/c CpG island, which bidirectionally regulates miR-34b/c and BTG4, is a frequent target of epigenetic silencing in CRC
      Title: Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer.
    4. BTG4 could contribute to chronic lymphocytic leykemia pathogenesis following inactivation by haploinsufficiency.
      Title: Identification of a potential role for POU2AF1 and BTG4 in the deletion of 11q23 in chronic lymphocytic leukemia.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:120141 BioGRID:126065 RNF19B    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:120141 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • RNA degradation, organism-specific biosystem (from KEGG)
      RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
    • RNA degradation, conserved biosystem (from KEGG)
      RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    cell cycle arrest TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    neuron differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
    		  
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    General protein information

    Preferred Names
    protein BTG4
    Names
    protein BTG4
    protein PC3b
    BTG family member 4
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017589.3 → NP_060059.1  protein BTG4

      Status: REVIEWED

      Source sequence(s)
      AJ271351, AP002008, BX099301
      Consensus CDS
      CCDS8346.1
      UniProtKB/Swiss-Prot
      Q9NY30
      Related
      ENSP00000348300, OTTHUMP00000234045, ENST00000356018, OTTHUMT00000391177
      Conserved Domains (1) summary
      cl15439
      Location:1 – 118
      Blast Score: 499
      BTG; BTG family

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      111338255..111383064, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      107262780..107307262, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AP002008.5 (78772..123581) None
    genomic CH471065.1 EAW67140.1
    genomic HC006790.1 CBH19201.1
    genomic HC044731.1 CBH30695.1
    mRNA AJ271351.1 CAB69821.1
    mRNA BC031045.1 AAH31045.1
    mRNA BX099301.1 None
    other-genetic DQ890978.2 ABM81904.1
    other-genetic DQ893718.2 ABM84644.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NEH7 GenPept UniProtKB/TrEMBL:Q8NEH7
    Q9NY30.1 GenPept UniProtKB/Swiss-Prot:Q9NY30
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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