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Tyk2 tyrosine kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 54721, updated on 28-May-2016
Official Symbol
Tyk2provided by MGI
Official Full Name
tyrosine kinase 2provided by MGI
Primary source
MGI:MGI:1929470
See related
Ensembl:ENSMUSG00000032175
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
JTK1
Orthologs
Location:
9; 9 A3
Exon count:
27
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 9 NC_000075.6 (21104068..21131275, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (20908512..20935719, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 38431 Neighboring gene ferredoxin 1-like Neighboring gene ribonucleoprotein, PTB-binding 1 Neighboring gene microRNA 7082 Neighboring gene cell division cycle 37 Neighboring gene predicted gene, 36118 Neighboring gene predicted gene, 35977 Neighboring gene predicted gene, 39301

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
    Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
  • Epstein-Barr virus infection, conserved biosystem (from KEGG)
    Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
  • Hepatitis C, organism-specific biosystem (from KEGG)
    Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Hepatitis C, conserved biosystem (from KEGG)
    Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Herpes simplex infection, organism-specific biosystem (from KEGG)
    Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Herpes simplex infection, conserved biosystem (from KEGG)
    Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
  • IL-4 signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-4 signaling Pathway, organism-specific biosystem
    IL-4 signaling Pathway
  • IL-6 signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-6 signaling Pathway, organism-specific biosystem
    IL-6 signaling Pathway
  • IL-9 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-9 Signaling Pathway, organism-specific biosystem
    IL-9 Signaling Pathway
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Influenza A, organism-specific biosystem (from KEGG)
    Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Influenza A, conserved biosystem (from KEGG)
    Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Interferon alpha/beta signaling, organism-specific biosystem (from REACTOME)
    Interferon alpha/beta signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • JAK-STAT signaling, organism-specific biosystem (from KEGG)
    JAK-STAT signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • JAK-STAT signaling, conserved biosystem (from KEGG)
    JAK-STAT signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Measles, organism-specific biosystem (from KEGG)
    Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Measles, conserved biosystem (from KEGG)
    Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Osteoclast differentiation, organism-specific biosystem (from KEGG)
    Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Osteoclast differentiation, conserved biosystem (from KEGG)
    Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Regulation of IFNA signaling, organism-specific biosystem (from REACTOME)
    Regulation of IFNA signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Toxoplasmosis, organism-specific biosystem (from KEGG)
    Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Toxoplasmosis, conserved biosystem (from KEGG)
    Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
growth hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
type 1 angiotensin receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
non-receptor tyrosine-protein kinase TYK2
Names
tyrosine kinase TYK2
NP_001192241.1
NP_061263.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205312.1NP_001192241.1  non-receptor tyrosine-protein kinase TYK2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC163637
    Consensus CDS
    CCDS57656.1
    UniProtKB/TrEMBL
    E9QJS1
    Related
    ENSMUSP00000001036, ENSMUST00000001036
    Conserved Domains (7) summary
    smart00219
    Location:9171189
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:45299
    B41; Band 4.1 homologues
    pfam07714
    Location:612886
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:459557
    SH2; Src homology 2 (SH2) domain
    cd05080
    Location:9121194
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cl21453
    Location:612887
    PKc_like; Protein Kinases, catalytic domain
    cl17171
    Location:296459
    PH-like; Pleckstrin homology-like domain
  2. NM_018793.2NP_061263.2  non-receptor tyrosine-protein kinase TYK2 isoform 2

    See identical proteins and their annotated locations for NP_061263.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC163637, AK171609, BC053021, BC094240
    UniProtKB/TrEMBL
    Q3TXE3, Q52KQ2
    Conserved Domains (7) summary
    smart00219
    Location:8941166
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:45276
    B41; Band 4.1 homologues
    pfam07714
    Location:589863
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:436534
    SH2; Src homology 2 (SH2) domain
    cd05080
    Location:8891171
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cl21453
    Location:589864
    PKc_like; Protein Kinases, catalytic domain
    cl17171
    Location:273436
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p3 C57BL/6J

    Range
    21104068..21131275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510492.2XP_006510555.1  

    Conserved Domains (6) summary
    smart00219
    Location:7901062
    TyrKc; Tyrosine kinase, catalytic domain
    pfam07714
    Location:485759
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:332430
    SH2; Src homology 2 (SH2) domain
    cd05080
    Location:7851067
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cl21453
    Location:485760
    PKc_like; Protein Kinases, catalytic domain
    cl17171
    Location:169332
    PH-like; Pleckstrin homology-like domain
  2. XM_011242579.1XP_011240881.1  

    See identical proteins and their annotated locations for XP_011240881.1

    UniProtKB/TrEMBL
    Q3TXE3
    Conserved Domains (7) summary
    smart00219
    Location:8941166
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:45276
    B41; Band 4.1 homologues
    pfam07714
    Location:589863
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:436534
    SH2; Src homology 2 (SH2) domain
    cd05080
    Location:8891171
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cl21453
    Location:589864
    PKc_like; Protein Kinases, catalytic domain
    cl17171
    Location:273436
    PH-like; Pleckstrin homology-like domain
  3. XM_006510493.2XP_006510556.1  

    Conserved Domains (6) summary
    smart00219
    Location:7311003
    TyrKc; Tyrosine kinase, catalytic domain
    pfam07714
    Location:426700
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:273371
    SH2; Src homology 2 (SH2) domain
    cd05080
    Location:7261008
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cl21453
    Location:426701
    PKc_like; Protein Kinases, catalytic domain
    cl17171
    Location:110273
    PH-like; Pleckstrin homology-like domain
  4. XM_006510494.1XP_006510557.1  

    Conserved Domains (5) summary
    smart00295
    Location:45276
    B41; Band 4.1 homologues
    cl15255
    Location:436534
    SH2; Src homology 2 (SH2) domain
    cd14473
    Location:151269
    FERM_B-lobe; FERM domain B-lobe
    cl21453
    Location:589722
    PKc_like; Protein Kinases, catalytic domain
    cl17171
    Location:273436
    PH-like; Pleckstrin homology-like domain
  5. XM_006510495.2XP_006510558.1  

    Conserved Domains (5) summary
    smart00295
    Location:45276
    B41; Band 4.1 homologues
    cl15255
    Location:436534
    SH2; Src homology 2 (SH2) domain
    cd14473
    Location:151269
    FERM_B-lobe; FERM domain B-lobe
    cl21453
    Location:589650
    PKc_like; Protein Kinases, catalytic domain
    cl17171
    Location:273436
    PH-like; Pleckstrin homology-like domain

Alternate Mm_Celera

Genomic

  1. AC_000031.1 Alternate Mm_Celera

    Range
    18372782..18399989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)