RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) [Homo sapiens] - Gene

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Summary

Official Symbol: RRN3provided by HGNC
Official Full Name: RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)provided by HGNC
Primary source: HGNC:30346
See related: Ensembl:ENSG00000085721; HPRD:12004; MIM:605121; Vega:OTTHUMG00000129847
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TIFIA; A-270G1.2; MGC104238; DKFZp566E104

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Genomic context

Location :: 16p12

Sequence :: Chromosome: 16; NC_000016.9 (15153879..15188158, complement)

See RRN3 in Epigenomics, MapViewer

Chromosome 16 - NC_000016.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

reveals the molecular basis of Rrn3-regulated Pol I initiation and cell growth
Title: Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth.
CK2 phosphorylates the transcription initiation factor TIF-IA at serines 170 and 172 (Ser170/172), and this phosphorylation triggers the release of TIF-IA from Pol I after transcription initiation.
Title: Phosphorylation by casein kinase 2 facilitates rRNA gene transcription by promoting dissociation of TIF-IA from elongating RNA polymerase I.
The definition of the Alu element within the TIF-IA gene as an exon is restricted to certain types of cancers; the element is not exonized in normal human cells.
Title: Biased exonization of transposed elements in duplicated genes: A lesson from the TIF-IA gene.
Phosphorylation of S44 activates and S199 inactivates TIF-IA.
Title: mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability.
ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth.
Title: ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth.
Data show that nutrient starvation, density arrest and protein synthesis inhibitors inactivate transcription initiation factor-IA and impair its association with RNA polymerase I.
Title: Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_060897.2	NP_001092.1	ACTB	BIND	PubMed	TIF-IA interacts with actin.
NP_060897.2	NP_057175.1	EIF3L	BIND	PubMed	TIF-IA interacts with PAF67. This interaction was modeled on a demonstrated interaction between human TIF-IA and PAF67 from an unspecified species.
NP_060897.2	NP_203693.2	MYO1C	BIND	PubMed	NMI interacts with TIF-IA.
NP_060897.2	NP_056240.1	POLR1A	BIND	PubMed	TIF-IA interacts with RPA43. This interaction was modeled on a demonstrated interaction between human TIF-IA and mouse RPA43.
NP_060897.2	NP_061887.2	POLR1B	BIND	PubMed	Pol I interacts with TIF-IA.
NP_060897.2	U13369.1	RIBIN	BIND	PubMed	TIF-IA interacts with rDNA.
NP_060897.2	NP_005671.1	TAF1B	BIND	PubMed	TIF-IA interacts with TAFI68. This interaction was modeled on a demonstrated interaction between human TIF-IA and TAFI68 from an unspecified species.
NP_060897.2		TAF1C	BIND	PubMed	TIF-IA interacts with TAFI95. This interaction was modeled on a demonstrated interaction between human TIF-IA and TAFI95 from an unspecified species.
Q9NYV6	Q9Y262	EIF3L	HPRD	PubMed
Q9NYV6	O00159	MYO1C	HPRD	PubMed
Q9NYV6	O95602	POLR1A	HPRD	PubMed
Q9NYV6	Q9H9Y6	POLR1B	HPRD	PubMed
Q9NYV6	Q53T94	TAF1B	HPRD	PubMed
Q9NYV6	Q15572	TAF1C	HPRD	PubMed
BioGRID:120102	BioGRID:107338	CCNE1	BioGRID	PubMed	Reconstituted Complex
BioGRID:120102	BioGRID:107452	CDK2	BioGRID	PubMed	Reconstituted Complex
BioGRID:120102	BioGRID:230176	Eif3l	BioGRID	PubMed	Affinity Capture-Western
BioGRID:120102	BioGRID:117396	POLR1A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:120102	BioGRID:122173	POLR1E	BioGRID	PubMed	Affinity Capture-Western
BioGRID:120102	BioGRID:111512	PPP2R2A	BioGRID	PubMed	Reconstituted Complex
BioGRID:120102	BioGRID:202993	Polr1b	BioGRID	PubMed	Affinity Capture-Western
BioGRID:120102	BioGRID:114484	TAF1A	BioGRID	PubMed	Reconstituted Complex
BioGRID:120102	BioGRID:114483	TAF1B	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:120102	BioGRID:114482	TAF1C	BioGRID	PubMed	Reconstituted Complex
BioGRID:120102	BioGRID:122548	TAF1D	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120102	BioGRID:112771	TBP	BioGRID	PubMed	Affinity Capture-Western
BioGRID:120102	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:120102	BioGRID:113190	UBTF	BioGRID	PubMed	Affinity Capture-Western

Process	Evidence Code	Pubs
gene expression	TAS Traceable Author Statement more info
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
transcription from RNA polymerase I promoter	TAS Traceable Author Statement more info
transcription initiation from RNA polymerase I promoter	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
nucleolus	IEA Inferred from Electronic Annotation more info
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: RNA polymerase I-specific transcription initiation factor RRN3

Names: RNA polymerase I-specific transcription initiation factor RRN3; TIF-IA; transcription initiation factor IA; transcription initiation factor TIF-IA

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018427.3 → NP_060897.3 RNA polymerase I-specific transcription initiation factor RRN3

Status: VALIDATED

Source sequence(s)

AF227156, AJ272050, BC071868, BU676519

Consensus CDS

CCDS10559.1

UniProtKB/Swiss-Prot

Q9NYV6

Related

ENSP00000198767, OTTHUMP00000160284, ENST00000198767, OTTHUMT00000252087

Conserved Domains (1) summary

pfam05327
Location:45 – 588
Blast Score: 1594

RRN3; RNA polymerase I specific transcription initiation factor RRN3

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000016.9 Reference GRCh37.p5 Primary Assembly

Range

15153879..15188158, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000148.1 Alternate HuRef

Range

14799197..14833480, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC139256.5 (60371..94604)	None
genomic	CH471301.2	EAW54754.1
mRNA	AF227156.1	AAF66160.1
mRNA	AJ272050.1	CAC07955.1
mRNA	AK225662.1	None
mRNA	AK295486.1	BAG58409.1
mRNA	AK300253.1	BAG62018.1
mRNA	AK302994.1	BAG64131.1
mRNA	AK303405.1	BAG64459.1
mRNA	AK304856.1	BAG65594.1
mRNA	AK314769.1	BAG37307.1
mRNA	AK316520.1	BAH14891.1
mRNA	AL110238.1	None
mRNA	BC036182.1	None
mRNA	BC071868.1	AAH71868.1
mRNA	BC104660.1	AAI04661.1
mRNA	BC132688.1	AAI32689.1
mRNA	BC132690.1	AAI32691.1
mRNA	BU676519.1	None
other-genetic	HQ258337.1	ADR83091.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
O75703	GenPept	UniProtKB/TrEMBL:O75703
Q3MHU9	GenPept	UniProtKB/TrEMBL:Q3MHU9
Q9NYV6.1	GenPept	UniProtKB/Swiss-Prot:Q9NYV6