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    MED1 mediator complex subunit 1 [ Homo sapiens ]

    Gene ID: 5469, updated on 11-May-2012
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    Summary

    Official Symbol
    MED1provided by HGNC
    Official Full Name
    mediator complex subunit 1provided by HGNC
    Primary source
    HGNC:9234
    See related
    Ensembl:ENSG00000125686; HPRD:05055; MIM:604311; Vega:OTTHUMG00000133216
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PBP; CRSP1; RB18A; TRIP2; PPARBP; CRSP200; DRIP205; DRIP230; PPARGBP; TRAP220; MGC71488
    Summary
    The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    17q12
    Sequence :
    Chromosome: 17; NC_000017.10 (37560538..37607527, complement)
    See MED1 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene SH3 and cysteine rich domain 2 Neighboring gene F-box and leucine-rich repeat protein 20 Neighboring gene cyclin-dependent kinase 12 Neighboring gene neuronal differentiation 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Activator-mediator binding stabilizes RNA polymerase II orientation within the human mediator-RNA polymerase II-TFIIF assembly. Bernecky C, et al. J Mol Biol, 2012 Apr 13. PMID 22343046.
    2. Regulation of androgen receptor-dependent transcription by coactivator MED1 is mediated through a newly discovered noncanonical binding motif. Jin F, et al. J Biol Chem, 2012 Jan 6. PMID 22102282.
    3. Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth. Chen Z, et al. EMBO J, 2011 May 10. PMID 21556051.
    4. Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth. Zhang D, et al. J Biol Chem, 2011 May 20. PMID 21454576.
    5. NCOA6 differentially regulates the expression of the CYP2C9 and CYP3A4 genes. Surapureddi S, et al. Pharmacol Res, 2011 May. PMID 21292004.

    See all (116) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. These results suggest that Mediator structural shifts induced by activator binding help stably orient pol II prior to transcription initiation within the human mediator-RNA polymerase II-TFIIF assembly.
      Title: Activator-mediator binding stabilizes RNA polymerase II orientation within the human mediator-RNA polymerase II-TFIIF assembly.
    2. Regulation of androgen receptor-dependent transcription by coactivator MED1 is mediated through a newly discovered noncanonical binding motif.
      Title: Regulation of androgen receptor-dependent transcription by coactivator MED1 is mediated through a newly discovered noncanonical binding motif.
    3. MED1 phosphorylation leads to ubiquitin-conjugating enzyme E2C (UBE2C) locus looping, UBE2C gene expression and cell growth in castration-resistant prostate cancer.
      Title: Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth.
    4. establish ARGLU1 as a new MED1-interacting protein required for estrogen-dependent gene transcription and breast cancer cell growth.
      Title: Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth.
    5. Vitamin D receptor rs2228570 polymorphism is associated with invasive ovarian carcinoma.
      Title: Vitamin D receptor rs2228570 polymorphism and invasive ovarian carcinoma risk: pooled analysis in five studies within the Ovarian Cancer Association Consortium.
    6. The core subunit MED1 facilitates VDR activity and regulating keratinocyte proliferation and differentiation
      Title: The transcriptional coactivator DRIP/mediator complex is involved in vitamin D receptor function and regulates keratinocyte proliferation and differentiation.
    7. analysis of molecular mechanism of binding TRAP220 coactivator to Retinoid X Receptor alpha, activated by 9-cis retinoic acid
      Title: Theoretical study of molecular mechanism of binding TRAP220 coactivator to Retinoid X Receptor alpha, activated by 9-cis retinoic acid.
    8. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    9. analysis of mediator in three different structural states: bound to the activator SREBP-1a, VP16, or an activator-free state
      Title: Activator-Mediator binding regulates Mediator-cofactor interactions.
    10. Results show that the cells of this aggressive form of breast cancer are genetically preprogrammed to depend on NR1D1 and PBP for the energy production necessary for survival.
      Title: An RNA interference screen identifies metabolic regulators NR1D1 and PBP as novel survival factors for breast cancer cells with the ERBB2 signature.
    Submit: New GeneRIF Correction See all (39)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_004765.2 NP_009225.1 BRCA1    BIND  PubMed BRCA1 interacts with TRAP220. 
    NP_004765.2 NC_000006.9 CDKN1A    BIND  PubMed MED1 interacts with p21 promoter. 
    NP_004765.2 NC_000011.8 CTSD    BIND  PubMed MED1 interacts with Cathepsin-D promoter. 
    NP_004765.2 NP_000116.1 ESR1    BIND  PubMed ESR1 (ER-alpha) interacts with PPARBP (TRAP220). This interaction was modeled on a demonstrated interaction between ESR1 from an unspecified species and PPARBP from an unspecified species. 
    NP_004765.2 NP_005113.1 NR1I3    BIND  PubMed CAR interacts with TRAP. 
    NP_004765.2 NC_000021.7 TFF1    BIND  PubMed MED1 interacts with pS2 promoter. 
    Q15648 P10275 AR    HPRD  PubMed  
    Q15648 P38398 BRCA1    HPRD  PubMed  
    Q15648 P03372 ESR1    HPRD  PubMed  
    Q15648 Q92731 ESR2    HPRD  PubMed  
    Q15648 P15976 GATA1    HPRD  PubMed  
    Q15648 P23771 GATA3    HPRD  PubMed  
    Q15648 P43694 GATA4    HPRD  PubMed  
    Q15648 Q92908 GATA6    HPRD  PubMed  
    Q15648 P41235 HNF4A    HPRD  PubMed  
    Q15648 Q00987 MDM2    HPRD  PubMed  
    Q15648 Q15648 MED1    HPRD  PubMed  
    Q15648 Q93074 MED12    HPRD  PubMed  
    Q15648 O60244 MED14    HPRD  PubMed  
    Q15648 Mediator of RNA polymerase II transcription subunit 25 homolog MED25    HPRD  PubMed  
    Q15648 Q96G25 MED8    HPRD  PubMed  
    Q15648 MED9 MED9    HPRD  PubMed  
    Q15648 P55055 NR1H2    HPRD  PubMed  
    Q15648 Q14994 NR1I3    HPRD  PubMed  
    Q15648 P22736 NR4A1    HPRD  PubMed  
    Q15648 Q07869 PPARA    HPRD  PubMed  
    Q15648 P37231 PPARG    HPRD  PubMed  
    Q15648 Q9UBK2 PPARGC1A    HPRD  PubMed  
    Q15648 P10276 RARA    HPRD  PubMed  
    Q15648 P35398 RORA    HPRD  PubMed  
    Q15648 P19793 RXRA    HPRD  PubMed  
    Q15648 P10827 THRA    HPRD  PubMed  
    Q15648 P37243 THRB    HPRD  PubMed  
    Q15648 P04637 TP53    HPRD  PubMed  
    Q15648 P11473 VDR    HPRD  PubMed  
    Q15648 Q04917 YWHAH    HPRD  PubMed  
    BioGRID:111465 BioGRID:106862 AR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111465 BioGRID:106962 ATM    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111465 BioGRID:107140 BRCA1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111465 BioGRID:117036 BRD4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111465 BioGRID:107333 CCNC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111465 BioGRID:116725 CDK19    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111465 BioGRID:107458 CDK8    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:111465 BioGRID:107459 CDK9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111465 BioGRID:114597 CTDP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111465 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-Western; FRET; Reconstituted Complex; Two-hybrid 
    BioGRID:111465 BioGRID:108404 ESR2    BioGRID  PubMed FRET; Reconstituted Complex; Two-hybrid 
    BioGRID:111465 BioGRID:108826 GABPA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111465 BioGRID:108893 GATA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111465 BioGRID:108894 GATA2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111465 BioGRID:109414 HNF4A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111465 BioGRID:108918 KAT2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111465 BioGRID:107029 KIF1A    BioGRID  PubMed Two-hybrid 
    BioGRID:111465 BioGRID:111465 MED1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111465 BioGRID:123974 MED10    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111465 BioGRID:134637 MED11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111465 BioGRID:115293 MED12    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111465 BioGRID:115294 MED13    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111465 BioGRID:114699 MED14    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111465 BioGRID:119623 MED15    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111465 BioGRID:115342 MED16    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111465 BioGRID:114830 MED17    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111465 BioGRID:120156 MED18    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111465 BioGRID:128553 MED19    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111465 BioGRID:114862 MED20    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111465 BioGRID:114807 MED21    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111465 BioGRID:112704 MED22    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111465 BioGRID:114829 MED23    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111465 BioGRID:115196 MED24    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:111465 BioGRID:123607 MED25    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization 
    BioGRID:111465 BioGRID:114831 MED26    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111465 BioGRID:114832 MED27    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111465 BioGRID:123219 MED28    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:111465 BioGRID:120734 MED29    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111465 BioGRID:124707 MED30    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111465 BioGRID:119211 MED31    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111465 BioGRID:118849 MED4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111465 BioGRID:115319 MED6    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111465 BioGRID:114833 MED7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111465 BioGRID:125219 MED8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111465 BioGRID:120403 MED9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111465 BioGRID:110694 MYC    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111465 BioGRID:116691 NCOA6    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111465 BioGRID:113222 NR1H2    BioGRID  PubMed Two-hybrid 
    BioGRID:111465 BioGRID:109165 NR3C1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111465 BioGRID:123054 OBFC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111465 BioGRID:106652 PARP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111465 BioGRID:111317 PIN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111465 BioGRID:111426 POLR2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111465 BioGRID:111430 POLR2E    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111465 BioGRID:111431 POLR2F    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111465 BioGRID:111445 POU1F1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111465 BioGRID:111464 PPARG    BioGRID  PubMed FRET; Reconstituted Complex; Two-hybrid 
    BioGRID:111465 BioGRID:116097 PPARGC1A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111465 BioGRID:202320 Pparg    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111465 BioGRID:114834 QKI    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111465 BioGRID:111849 RARA    BioGRID  PubMed Affinity Capture-Western; FRET; Reconstituted Complex; Two-hybrid 
    BioGRID:111465 BioGRID:112168 RXRA    BioGRID  PubMed Co-localization; Reconstituted Complex; Two-hybrid 
    BioGRID:111465 BioGRID:112598 SREBF1    BioGRID  PubMed Co-localization; Co-purification; Reconstituted Complex 
    BioGRID:111465 BioGRID:114042 SUPT3H    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111465 BioGRID:115242 SUPT7L    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111465 BioGRID:112734 TADA2A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111465 BioGRID:125179 TGS1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111465 BioGRID:112923 THRA    BioGRID  PubMed Affinity Capture-Western; Far Western; Reconstituted Complex 
    BioGRID:111465 BioGRID:115292 THRAP3    BioGRID  PubMed Co-purification 
    BioGRID:111465 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111465 BioGRID:112815 TRA@    BioGRID  PubMed Co-purification 
    BioGRID:111465 BioGRID:114735 TRIP4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111465 BioGRID:113900 TRRAP    BioGRID  PubMed Co-purification 
    BioGRID:111465 BioGRID:246950 Thrb    BioGRID  PubMed Two-hybrid 
    BioGRID:111465 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111465 BioGRID:113264 VDR    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid 
    BioGRID:111465 BioGRID:116168 YWHAQ    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111465 BioGRID:116719 ZC3H13    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem (from REACTOME)
      BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystemAs inferred from mouse, BMAL1:CLOCK and BMAL1:NPAS2 heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et al. 1998, reviewed in Munoz...
    • Circadian Clock, organism-specific biosystem (from REACTOME)
      Circadian Clock, organism-specific biosystemAt the center of the mammalian circadian clock is a negative transcription/translation-based feedback loop: The BMAL1:CLOCK/NPAS2 heterodimer transactivates CRY and PER genes by binding E-box element...
    • Circadian Repression of Expression by REV-ERBA, organism-specific biosystem (from REACTOME)
      Circadian Repression of Expression by REV-ERBA, organism-specific biosystemREV-ERBA binds DNA elements very similar to those bound by the transcription activator RORA. RORAREV-ERBA bound to DNA and heme recruits the corepressors NCoR and HDAC3 to repress transcription. Thu...
    • Coregulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
      Coregulation of Androgen receptor activity, organism-specific biosystem
      Coregulation of Androgen receptor activity
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Energy Metabolism, organism-specific biosystem (from WikiPathways)
      Energy Metabolism, organism-specific biosystemThe PPARGC1A protein is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with the nuclear receptor PPARG, which permits the interaction of ...
    • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
      Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Nuclear Receptor transcription pathway, organism-specific biosystem (from REACTOME)
      Nuclear Receptor transcription pathway, organism-specific biosystemA classic example of bifunctional transcription factors is the family of Nuclear Receptor (NR) proteins. These are DNA-binding transcription factors that bind certain hormones, vitamins, and other s...
    • PPARA Activates Gene Expression, organism-specific biosystem (from REACTOME)
      PPARA Activates Gene Expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
    • RORA Activates Circadian Expression, organism-specific biosystem (from REACTOME)
      RORA Activates Circadian Expression, organism-specific biosystemAs inferred from mouse, RORA binds ROR elements (ROREs) in DNA and recruits the coactivators PPARGC1A (PGC-1alpha) and p300 (EP300, a histone acetylase) to activate transcription.
    • RXR and RAR heterodimerization with other nuclear receptor, organism-specific biosystem (from Pathway Interaction Database)
      RXR and RAR heterodimerization with other nuclear receptor, organism-specific biosystem
      RXR and RAR heterodimerization with other nuclear receptor
    • Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
      Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
    • Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystem (from REACTOME)
      Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystemAdipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develo...
    • YAP1- and WWTR1 (TAZ)-stimulated gene expression, organism-specific biosystem (from REACTOME)
      YAP1- and WWTR1 (TAZ)-stimulated gene expression, organism-specific biosystemYAP1 and WWTR1 (TAZ) are transcriptional co-activators, both homologues of the Drosophila Yorkie protein. They both interact with members of the TEAD family of transcription factors, and WWTR1 intera...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    LBD domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    RNA polymerase II transcription cofactor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    chromatin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    core promoter binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    estrogen receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ligand-dependent nuclear receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ligand-dependent nuclear receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ligand-dependent nuclear receptor transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    ligand-dependent nuclear receptor transcription coactivator activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    mediator complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    peroxisome proliferator activated receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    retinoic acid receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    sequence-specific DNA binding RNA polymerase II transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    thyroid hormone receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    thyroid hormone receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    thyroid hormone receptor coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    transcription cofactor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    vitamin D receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    vitamin D receptor binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    vitamin D receptor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    androgen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    androgen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    brain development IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cellular lipid metabolic process TAS
    Traceable Author Statement
    more info
    		  
    cellular response to epidermal growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cellular response to hepatocyte growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to steroid hormone stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cellular response to thyroid hormone stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    embryonic heart tube development IEA
    Inferred from Electronic Annotation
    more info
    		  
    embryonic hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    embryonic hindlimb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    embryonic placenta development IEA
    Inferred from Electronic Annotation
    more info
    		  
    enucleate erythrocyte development IEA
    Inferred from Electronic Annotation
    more info
    		  
    epithelial cell proliferation involved in mammary gland duct elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    erythrocyte development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    gene expression TAS
    Traceable Author Statement
    more info
    		  
    intracellular steroid hormone receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    keratinocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    lactation IEA
    Inferred from Electronic Annotation
    more info
    		  
    lens development in camera-type eye ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    liver development IEA
    Inferred from Electronic Annotation
    more info
    		  
    mRNA transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    mammary gland branching involved in pregnancy IEA
    Inferred from Electronic Annotation
    more info
    		  
    mammary gland branching involved in thelarche IEA
    Inferred from Electronic Annotation
    more info
    		  
    megakaryocyte development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    monocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of keratinocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    organ regeneration IEA
    Inferred from Electronic Annotation
    more info
    		  
    peroxisome proliferator activated receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of G0 to G1 transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of hepatocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of interferon-gamma-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of keratinocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of mammary gland epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of protein import into nucleus, translocation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of RNA biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    regulation of transcription from RNA polymerase I promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of vitamin D receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    retinal pigment epithelium development IEA
    Inferred from Electronic Annotation
    more info
    		  
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
    		  
    thyroid hormone generation IEA
    Inferred from Electronic Annotation
    more info
    		  
    thyroid hormone mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    transcription initiation from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ventricular trabecula myocardium morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mediator complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    mediator of RNA polymerase II transcription subunit 1
    Names
    mediator of RNA polymerase II transcription subunit 1
    ARC205
    TRIP-2
    PPAR binding protein
    PPAR-binding protein
    PPARG binding protein
    TR-interacting protein 2
    p53 regulatory protein RB18A
    thyroid receptor interacting protein 2
    thyroid receptor-interacting protein 2
    vitamin D receptor-interacting protein 230 kD
    activator-recruited cofactor 205 kDa component
    peroxisome proliferator-activated receptor-binding protein
    vitamin D receptor-interacting protein complex component DRIP205
    thyroid hormone receptor-associated protein complex 220 kDa component
    thyroid hormone receptor-associated protein complex component TRAP220
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004774.3 → NP_004765.2  mediator of RNA polymerase II transcription subunit 1

      Status: REVIEWED

      Source sequence(s)
      AC005288, BC131783, BP357374
      Consensus CDS
      CCDS11336.1
      UniProtKB/Swiss-Prot
      Q15648
      Related
      ENSP00000300651, OTTHUMP00000164284, ENST00000300651, OTTHUMT00000256943
      Conserved Domains (1) summary
      pfam10744
      Location:35 – 429
      Blast Score: 863
      Med1; Mediator of RNA polymerase II transcription subunit 1

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      37560538..37607527, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      33354022..33401237, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC005288.1 None
    genomic AC009283.6 (14537..57175) None
    genomic AF157513.1 None
    genomic CH471152.1 EAW60575.1
    mRNA AF055994.1 AAC39854.1
    mRNA AF283812.1 AAF98352.1
    mRNA AK299789.1 BAG61669.1
    mRNA AK314185.1 BAG36866.1
    mRNA BC006517.2 AAH06517.1
    mRNA BC060758.1 AAH60758.1
    mRNA BC131783.1 AAI31784.1
    mRNA BP357374.1 None
    mRNA L40366.1 AAC41736.1
    mRNA Y13467.1 CAA73867.1
    other-genetic JF432429.1 ADZ15646.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15648.4 GenPept UniProtKB/Swiss-Prot:Q15648
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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    Miscellaneous

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