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CRLS1 cardiolipin synthase 1 [ Homo sapiens (human) ]

Gene ID: 54675, updated on 21-Oct-2014
Official Symbol
CRLS1provided by HGNC
Official Full Name
cardiolipin synthase 1provided by HGNC
Primary source
HGNC:HGNC:16148
See related
Ensembl:ENSG00000088766; HPRD:12187; MIM:608188; Vega:OTTHUMG00000031823
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLS; CLS1; GCD10; C20orf155; dJ967N21.6
See CRLS1 in Epigenomics, MapViewer
Location:
20p13-p12.3
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 20 NC_000020.11 (6006089..6040072)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (5986739..6020699)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 6 homolog (S. cerevisiae) Neighboring gene minichromosome maintenance complex component 8 Neighboring gene MCM8 antisense RNA 1 Neighboring gene leucine rich repeat neuronal 4 Neighboring gene fermitin family member 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Acyl chain remodelling of PG, organism-specific biosystem (from REACTOME)
    Acyl chain remodelling of PG, organism-specific biosystemIn the acyl chain remodelling pathway (Lands cycle), phosphatidylglycerol (PG) is hydrolyzed by phopholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid comp...
  • Glycerophospholipid biosynthesis, organism-specific biosystem (from REACTOME)
    Glycerophospholipid biosynthesis, organism-specific biosystemGlycerophospholipids are important structural and functional components of biological membranes and constituents of serum lipoproteins and the pulmonary surfactant. In addition, glycerophospholipids...
  • Glycerophospholipid metabolism, organism-specific biosystem (from KEGG)
    Glycerophospholipid metabolism, organism-specific biosystem
    Glycerophospholipid metabolism
  • Glycerophospholipid metabolism, conserved biosystem (from KEGG)
    Glycerophospholipid metabolism, conserved biosystem
    Glycerophospholipid metabolism
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Phospholipid metabolism, organism-specific biosystem (from REACTOME)
    Phospholipid metabolism, organism-specific biosystemPhospholipids contain a polar head group and two long-chain fatty acyl moieties, one of which is generally unsaturated. The head group is a glycerol or serine phosphate attached to a polar group such...
  • Synthesis of CL, organism-specific biosystem (from REACTOME)
    Synthesis of CL, organism-specific biosystemCardiolipin(CL) is synthesized in the inner mitochondrial membrane (IM), when phosphatidylglycerol (PG) and cytidine diphosphate-diacylglycerol (CDP-DAG) are converted into CL (Lu et al. 2006, Houtko...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cardiolipin biosynthetic process TAS
Traceable Author Statement
more info
 
glycerophospholipid biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylglycerol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phospholipid metabolic process TAS
Traceable Author Statement
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
Preferred Names
cardiolipin synthase
Names
cardiolipin synthase

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127458.1NP_001120930.1  cardiolipin synthase isoform 2

    See proteins identical to NP_001120930.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate first exon which contains the translation initiation site. The resulting protein isoform (2) has a short distinct N-terminus.
    Source sequence(s)
    AK310368, AL832419, BP368984
    Consensus CDS
    CCDS46578.1
    UniProtKB/Swiss-Prot
    Q9UJA2
    Conserved Domains (1) summary
    cl00453
    Location:10189
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase
  2. NM_019095.4NP_061968.1  cardiolipin synthase isoform 1

    See proteins identical to NP_061968.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate first exon which contains the translation initiation site. The resulting protein isoform (1) has a distinct N-terminus.
    Source sequence(s)
    AF241784, AL035461, AL832419, BM763234
    Consensus CDS
    CCDS13096.1
    UniProtKB/Swiss-Prot
    Q9UJA2
    Related
    ENSP00000368140, OTTHUMP00000030219, ENST00000378863, OTTHUMT00000077902
    Conserved Domains (1) summary
    cl00453
    Location:101288
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000020.11 

    Range
    6006089..6040072
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723579.1XP_006723642.1  

    Conserved Domains (1) summary
    cl00453
    Location:101190
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase
  2. XM_005260737.2XP_005260794.1  

    See proteins identical to XP_005260794.1

    Conserved Domains (1) summary
    cl00453
    Location:1177
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase
  3. XM_006723580.1XP_006723643.1  

    See proteins identical to XP_006723643.1

    Conserved Domains (1) summary
    cl00453
    Location:1177
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase
  4. XM_005260738.2XP_005260795.1  

    See proteins identical to XP_005260795.1

    Conserved Domains (1) summary
    cl00453
    Location:1177
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

Alternate HuRef

Genomic

  1. AC_000152.1 

    Range
    5943143..5977077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 

    Range
    5986812..6020722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)