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PPARD peroxisome proliferator activated receptor delta [ Homo sapiens (human) ]

Gene ID: 5467, updated on 22-May-2016
Official Symbol
PPARDprovided by HGNC
Official Full Name
peroxisome proliferator activated receptor deltaprovided by HGNC
Primary source
HGNC:HGNC:9235
See related
Ensembl:ENSG00000112033 HPRD:02679; MIM:600409; Vega:OTTHUMG00000014567
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAAR; NUC1; NUCI; NR1C2; NUCII; PPARB
Summary
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
Orthologs
Location:
6p21.2
Exon count:
11
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (35342558..35428191)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (35310335..35395968)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 76 Neighboring gene DEF6, guanine nucleotide exchange factor Neighboring gene makorin ring finger protein 6, pseudogene Neighboring gene Fanconi anemia complementation group E

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
NHGRI GWA Catalog
Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.
NHGRI GWA Catalog
Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.
NHGRI GWA Catalog
Novel susceptibility genes associated with diabetic cataract in a Taiwanese population.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr regulates mitochondrial respiration and enhances the activity of hydroxyacyl-CoA dehydrogenase (HADH) through PPARbeta/delta PubMed
vpr HIV-1 Vpr enhances PPARbeta/delta-induced PDK4, carnitine palmitoyltransferase I (CPT1), and acetyl-coenzyme A acyltransferase 2 (ACAA2) mRNA expression in cells PubMed
vpr HIV-1 Vpr enhances PPARbeta/delta agonist GW501516-induced pyruvate dehydrogenase kinase 4 (PDK4) protein expression and phosphorylation of pyruvate dehydrogenase alpha 1 (PDHE1alpha) at serine 293 in cells PubMed
vpr HIV-1 Vpr physically interacts with the LXXLL motif (residues 64-68) of PPARbeta/delta in vivo and in vitro and enhances PPARbeta/delta-induced transcription activity PubMed

Go to the HIV-1, Human Interaction Database

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    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC3931

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
NF-kappaB binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
drug binding IDA
Inferred from Direct Assay
more info
PubMed 
linoleic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
lipid binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
steroid hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 
transcription factor activity, sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor activity, sequence-specific DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding ISS
Inferred from Sequence or Structural Similarity
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
adipose tissue development IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
axon ensheathment ISS
Inferred from Sequence or Structural Similarity
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
cholesterol metabolic process TAS
Traceable Author Statement
more info
PubMed 
decidualization TAS
Traceable Author Statement
more info
PubMed 
embryo implantation TAS
Traceable Author Statement
more info
PubMed 
fatty acid beta-oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 
fatty acid beta-oxidation TAS
Traceable Author Statement
more info
PubMed 
fatty acid catabolic process TAS
Traceable Author Statement
more info
PubMed 
fatty acid transport ISS
Inferred from Sequence or Structural Similarity
more info
 
generation of precursor metabolites and energy TAS
Traceable Author Statement
more info
PubMed 
glucose metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
glucose transport NAS
Non-traceable Author Statement
more info
PubMed 
heart development IEA
Inferred from Electronic Annotation
more info
 
intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
keratinocyte migration IEA
Inferred from Electronic Annotation
more info
 
keratinocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA transcription IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of collagen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of pri-miRNA transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epidermis development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fat cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of myoblast proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of skeletal muscle tissue regeneration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of vasodilation IEA
Inferred from Electronic Annotation
more info
 
proteoglycan metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of skeletal muscle satellite cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
response to activity IEA
Inferred from Electronic Annotation
more info
 
response to glucose IEA
Inferred from Electronic Annotation
more info
 
response to vitamin A IEA
Inferred from Electronic Annotation
more info
 
steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
vitamin A metabolic process IEA
Inferred from Electronic Annotation
more info
 
wound healing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear chromatin ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
peroxisome proliferator-activated receptor delta
Names
PPAR-beta
PPAR-delta
nuclear hormone receptor 1
nuclear receptor subfamily 1 group C member 2
peroxisome proliferator-activated nuclear receptor beta/delta variant 2
peroxisome proliferator-activated receptor beta

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012345.1 RefSeqGene

    Range
    5001..90634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001171818.1NP_001165289.1  peroxisome proliferator-activated receptor delta isoform 1

    See identical proteins and their annotated locations for NP_001165289.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AB099507, AK122614, AL022721, BE503383, DA192442
    Consensus CDS
    CCDS4803.1
    UniProtKB/Swiss-Prot
    Q03181
    UniProtKB/TrEMBL
    A0A024RCW6
    Related
    ENSP00000310928, OTTHUMP00000016256, ENST00000311565, OTTHUMT00000040288
    Conserved Domains (2) summary
    cd06932
    Location:173440
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:73156
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  2. NM_001171819.1NP_001165290.1  peroxisome proliferator-activated receptor delta isoform 3

    See identical proteins and their annotated locations for NP_001165290.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK122614, AK296425, AL022721, BE503383, DA192442
    Consensus CDS
    CCDS54994.1
    UniProtKB/Swiss-Prot
    Q03181
    Related
    ENSP00000414372, ENST00000448077
    Conserved Domains (2) summary
    cd06932
    Location:134401
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:34117
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  3. NM_001171820.1NP_001165291.1  peroxisome proliferator-activated receptor delta isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AK122614, AK304878, AL022721, BE503383, DA192442
    Consensus CDS
    CCDS54995.1
    UniProtKB/Swiss-Prot
    Q03181
    Related
    ENSP00000413314, ENST00000418635
    Conserved Domains (2) summary
    cd06932
    Location:75342
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cl02596
    Location:4158
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
  4. NM_006238.4NP_006229.1  peroxisome proliferator-activated receptor delta isoform 1

    See identical proteins and their annotated locations for NP_006229.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Both variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AK122614, BE503383, DA192442
    Consensus CDS
    CCDS4803.1
    UniProtKB/Swiss-Prot
    Q03181
    UniProtKB/TrEMBL
    A0A024RCW6
    Related
    ENSP00000353916, ENST00000360694
    Conserved Domains (2) summary
    cd06932
    Location:173440
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:73156
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  5. NM_177435.2NP_803184.1  peroxisome proliferator-activated receptor delta isoform 2

    See identical proteins and their annotated locations for NP_803184.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region and 3'UTR. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC002715, CN332566, DA192442, DA476590
    Consensus CDS
    CCDS4804.1
    UniProtKB/Swiss-Prot
    Q03181
    UniProtKB/TrEMBL
    F1D8S7
    Related
    ENSP00000337063, OTTHUMP00000016257, ENST00000337400, OTTHUMT00000040289
    Conserved Domains (2) summary
    cd06965
    Location:73156
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    cl11397
    Location:173359
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    35342558..35428191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514712.1XP_011513014.1  

    See identical proteins and their annotated locations for XP_011513014.1

    UniProtKB/Swiss-Prot
    Q03181
    UniProtKB/TrEMBL
    A0A024RCW6
    Conserved Domains (2) summary
    cd06932
    Location:173440
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:73156
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  2. XM_005249193.1XP_005249250.1  

    See identical proteins and their annotated locations for XP_005249250.1

    UniProtKB/Swiss-Prot
    Q03181
    UniProtKB/TrEMBL
    A0A024RCW6
    Conserved Domains (2) summary
    cd06932
    Location:173440
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:73156
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  3. XM_011514707.1XP_011513009.1  

    See identical proteins and their annotated locations for XP_011513009.1

    UniProtKB/Swiss-Prot
    Q03181
    UniProtKB/TrEMBL
    A0A024RCW6
    Conserved Domains (2) summary
    cd06932
    Location:173440
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:73156
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  4. XM_011514713.1XP_011513015.1  

    See identical proteins and their annotated locations for XP_011513015.1

    Conserved Domains (2) summary
    cd06965
    Location:73156
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    cl11397
    Location:173359
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  5. XM_011514709.1XP_011513011.1  

    See identical proteins and their annotated locations for XP_011513011.1

    UniProtKB/Swiss-Prot
    Q03181
    UniProtKB/TrEMBL
    A0A024RCW6
    Conserved Domains (2) summary
    cd06932
    Location:173440
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:73156
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  6. XM_011514708.1XP_011513010.1  

    See identical proteins and their annotated locations for XP_011513010.1

    UniProtKB/Swiss-Prot
    Q03181
    UniProtKB/TrEMBL
    A0A024RCW6
    Conserved Domains (2) summary
    cd06932
    Location:173440
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:73156
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  7. XM_006715121.1XP_006715184.1  

    See identical proteins and their annotated locations for XP_006715184.1

    UniProtKB/Swiss-Prot
    Q03181
    UniProtKB/TrEMBL
    A0A024RCW6
    Conserved Domains (2) summary
    cd06932
    Location:173440
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:73156
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  8. XM_006715120.1XP_006715183.1  

    See identical proteins and their annotated locations for XP_006715183.1

    UniProtKB/Swiss-Prot
    Q03181
    UniProtKB/TrEMBL
    A0A024RCW6
    Conserved Domains (2) summary
    cd06932
    Location:173440
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:73156
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  9. XM_011514710.1XP_011513012.1  

    See identical proteins and their annotated locations for XP_011513012.1

    UniProtKB/Swiss-Prot
    Q03181
    UniProtKB/TrEMBL
    A0A024RCW6
    Conserved Domains (2) summary
    cd06932
    Location:173440
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:73156
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  10. XM_011514711.1XP_011513013.1  

    See identical proteins and their annotated locations for XP_011513013.1

    UniProtKB/Swiss-Prot
    Q03181
    UniProtKB/TrEMBL
    A0A024RCW6
    Conserved Domains (2) summary
    cd06932
    Location:173440
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:73156
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  11. XM_006715123.1XP_006715186.1  

    See identical proteins and their annotated locations for XP_006715186.1

    UniProtKB/Swiss-Prot
    Q03181
    UniProtKB/TrEMBL
    A0A024RCW6
    Conserved Domains (2) summary
    cd06932
    Location:173440
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:73156
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    35312398..35397989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)