UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: UGT1A1provided by HGNC
Official Full Name: UDP glucuronosyltransferase 1 family, polypeptide A1provided by HGNC
Primary source: HGNC:12530
See related: Ensembl:ENSG00000241635; HPRD:08933; MIM:191740; Vega:OTTHUMG00000059117
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GNT1; UGT1; UDPGT; UGT1A; HUG-BR1; BILIQTL1; UDPGT 1-1
Summary: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 2q37

Sequence :: Chromosome: 2; NC_000002.11 (234668919..234681945)

See UGT1A1 in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

SNPs in UGT1A, other than UGT1A1*28, may influence irinotecan toxicity and should be considered to refine pharmacogenetic testing.
Title: Refining the UGT1A haplotype associated with irinotecan-induced hematological toxicity in metastatic colorectal cancer patients treated with 5-fluorouracil/irinotecan-based regimens.
UGT1A1 is the principal enzyme responsible for puerarin metabolism in human liver microsomes.
Title: UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for puerarin metabolism in human liver microsomes.
the Tunisian population appears to be heterogeneous view UGT1A1 gene mutation status
Title: [Polymorphisms of the UDP-glucuronosyltransferase 1-A1 gene in Tunisian population].
Co-immunoprecipitation assays showed that UGT1A1 lacking the SP (signal peptide) alone or also lacking the transmembrane domain (absent from i2) did not self-interact, but still interacted with i2
Title: Protein-protein interactions between the bilirubin-conjugating UDP-glucuronosyltransferase UGT1A1 and its shorter isoform 2 regulatory partner derived from alternative splicing.
the UGT1A1*28 genotype was associated with an increased likelihood of hyperbilirubinemia in a large, prospective clinical trial and was associated with an increased likelihood of atazanavir/r discontinuation.
Title: Impact of UGT1A1 Gilbert variant on discontinuation of ritonavir-boosted atazanavir in AIDS Clinical Trials Group Study A5202.
The individual differences in the adverse The responses to a popular antineoplastic agent, irinotecan, has been reputed to be related to UGT1A1 polymorphism.
Title: [Importance and practice of UGT1A1 polymorphisms].
The expression of UGT1A1 v2/v3 was 1.6-fold higher than v1 (p = 0.03) in HepG2 cells.
Title: Quantification of Hepatic UDP glucuronosyltransferase 1A splice variant expression and correlation of UDP glucuronosyltransferase 1A1 variant expression with glucuronidation activity.
LPS mediates the suppression of UGT1A1 expression through specific binding of NF-kappaB to this newly identified NF-kappaB-binding site in the upstream promoter of the UGT1A1 gene.
Title: Nuclear factor κB down-regulates human UDP-glucuronosyltransferase 1A1: a novel mechanism involved in inflammation-associated hyperbilirubinaemia.
UGT1A1 polymorphisms were associated with toxicity and efficacy of irinotecan monotherapy in patients with advanced pancreatic cancer
Title: Uridine diphosphate glucuronosyl transferase 1 family polypeptide A1 gene (UGT1A1) polymorphisms are associated with toxicity and efficacy in irinotecan monotherapy for refractory pancreatic cancer.
UGT1A1 polymorphisms are associated with development of head and neck cancers.
Title: Effects of cytochrome P450 1A1 and uridine-diphosphate-glucuronosyltransferase 1A1 allelic polymorphisms on the risk of development and the prognosis of head and neck cancers.

Submit: New GeneRIF Correction See all (245)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Bilirubin, serum level of, quantitative trait locus 1

MIM: 601816

Genetic Testing Registry

Crigler-Najjar syndrome, type II

MIM: 606785

Genetic Testing Registry

NHGRI GWAS Catalog

A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study.

A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia.

Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.

Genome-wide association meta-analysis for total serum bilirubin levels.

Human metabolic individuality in biomedical and pharmaceutical research.

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_000454.1			BIND	PubMed	UGT1A1 interacts with 5-hydroxyrofecoxib.
BioGRID:120087	BioGRID:114251	B3GALT1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:120087	BioGRID:116495	COPZ1	BioGRID	PubMed	Protein-peptide
BioGRID:120087	BioGRID:115746	SEC23B	BioGRID	PubMed	Protein-peptide
BioGRID:120087	BioGRID:113205	UGDH	BioGRID	PubMed	Two-hybrid

Pathways from BioSystems

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AhR pathway, organism-specific biosystem (from WikiPathways)
AhR pathway, organism-specific biosystem
AhR pathway
Ascorbate and aldarate metabolism, organism-specific biosystem (from KEGG)
Ascorbate and aldarate metabolism, organism-specific biosystem
Ascorbate and aldarate metabolism
Ascorbate and aldarate metabolism, conserved biosystem (from KEGG)
Ascorbate and aldarate metabolism, conserved biosystem
Ascorbate and aldarate metabolism
Ascorbate biosynthesis, animals, glucose-1P => ascorbate, organism-specific biosystem (from KEGG)
Ascorbate biosynthesis, animals, glucose-1P => ascorbate, organism-specific biosystemPathway module; Nucleotide and amino acid metabolism; Cofactor and vitamin biosynthesis
Ascorbate biosynthesis, animals, glucose-1P => ascorbate, conserved biosystem (from KEGG)
Ascorbate biosynthesis, animals, glucose-1P => ascorbate, conserved biosystemPathway module; Nucleotide and amino acid metabolism; Cofactor and vitamin biosynthesis
Biological oxidations, organism-specific biosystem (from REACTOME)
Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
Chemical carcinogenesis, organism-specific biosystem (from KEGG)
Chemical carcinogenesis, organism-specific biosystemIt has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens ...
Chemical carcinogenesis, conserved biosystem (from KEGG)
Chemical carcinogenesis, conserved biosystemIt has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens ...
Codeine and morphine metabolism, organism-specific biosystem (from WikiPathways)
Codeine and morphine metabolism, organism-specific biosystemThe principal pathways for metabolism of codeine occur in the liver, although some metabolism occurs in the intestine and brain. Approximately 50-70% of codeine is converted to codeine-6-glucuronide ...
Drug metabolism - cytochrome P450, organism-specific biosystem (from KEGG)
Drug metabolism - cytochrome P450, organism-specific biosystem
Drug metabolism - cytochrome P450
Drug metabolism - cytochrome P450, conserved biosystem (from KEGG)
Drug metabolism - cytochrome P450, conserved biosystem
Drug metabolism - cytochrome P450
Drug metabolism - other enzymes, organism-specific biosystem (from KEGG)
Drug metabolism - other enzymes, organism-specific biosystem
Drug metabolism - other enzymes
Drug metabolism - other enzymes, conserved biosystem (from KEGG)
Drug metabolism - other enzymes, conserved biosystem
Drug metabolism - other enzymes
Estrogen metabolism, organism-specific biosystem (from WikiPathways)
Estrogen metabolism, organism-specific biosystem
Estrogen metabolism
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
Glucuronidation, organism-specific biosystem (from WikiPathways)
Glucuronidation, organism-specific biosystemMetabolism of xenobiotic compounds consists of phase I and a phase II biotransformation reactions, being compound modification and conjugation reactions respectively. In phase I biotransformation, th...
Glucuronidation, organism-specific biosystem (from REACTOME)
Glucuronidation, organism-specific biosystemGlucuronidation conjugation utilizes UDP-glucuronosyltransferases (UGTs; EC 2.4.1.17) to catalyze a wide range of diverse endogenous and xenobiotic compounds. Glucuronidation is the major pathway in ...
Heme degradation, organism-specific biosystem (from REACTOME)
Heme degradation, organism-specific biosystemMost of the heme degraded in humans comes from hemoglobin. Approximately 6-8 grams of hemoglobin is degraded daily which is equivalent to approximately 300 milligrams of heme per day. Heme is not rec...
Irinotecan Pathway, organism-specific biosystem (from WikiPathways)
Irinotecan Pathway, organism-specific biosystemThis pathway shows the biotransformation of the chemotherapy prodrug irinotecan to form the active metabolite SN-38, an inhibitor of DNA topoisomerase I. SN-38 is primarily metabolized to the inactiv...
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
Metabolism of porphyrins, organism-specific biosystem (from REACTOME)
Metabolism of porphyrins, organism-specific biosystemPorphyrins are heterocyclic macrocycles, consisting of four pyrrole subunits (tetrapyrrole) linked by four methine (=CH-) bridges. The extensive conjugated porphyrin macrocycle is chromatic and the n...
Metabolism of xenobiotics by cytochrome P450, organism-specific biosystem (from KEGG)
Metabolism of xenobiotics by cytochrome P450, organism-specific biosystem
Metabolism of xenobiotics by cytochrome P450
Metabolism of xenobiotics by cytochrome P450, conserved biosystem (from KEGG)
Metabolism of xenobiotics by cytochrome P450, conserved biosystem
Metabolism of xenobiotics by cytochrome P450
PPARA Activates Gene Expression, organism-specific biosystem (from REACTOME)
PPARA Activates Gene Expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
Pentose and glucuronate interconversions, organism-specific biosystem (from KEGG)
Pentose and glucuronate interconversions, organism-specific biosystem
Pentose and glucuronate interconversions
Pentose and glucuronate interconversions, conserved biosystem (from KEGG)
Pentose and glucuronate interconversions, conserved biosystem
Pentose and glucuronate interconversions
Phase II conjugation, organism-specific biosystem (from REACTOME)
Phase II conjugation, organism-specific biosystemPhase II of biotransformation is concerned with conjugation, that is using groups from cofactors to react with functional groups present or introduced from phase I on the compound. The enzymes involv...
Porphyrin and chlorophyll metabolism, organism-specific biosystem (from KEGG)
Porphyrin and chlorophyll metabolism, organism-specific biosystem
Porphyrin and chlorophyll metabolism
Porphyrin and chlorophyll metabolism, conserved biosystem (from KEGG)
Porphyrin and chlorophyll metabolism, conserved biosystem
Porphyrin and chlorophyll metabolism
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
Retinol metabolism, organism-specific biosystem (from KEGG)
Retinol metabolism, organism-specific biosystem
Retinol metabolism
Retinol metabolism, conserved biosystem (from KEGG)
Retinol metabolism, conserved biosystem
Retinol metabolism
Starch and sucrose metabolism, organism-specific biosystem (from KEGG)
Starch and sucrose metabolism, organism-specific biosystem
Starch and sucrose metabolism
Starch and sucrose metabolism, conserved biosystem (from KEGG)
Starch and sucrose metabolism, conserved biosystem
Starch and sucrose metabolism
Steroid hormone biosynthesis, organism-specific biosystem (from KEGG)
Steroid hormone biosynthesis, organism-specific biosystemSteroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 co...
Steroid hormone biosynthesis, conserved biosystem (from KEGG)
Steroid hormone biosynthesis, conserved biosystemSteroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 co...
metapathway biotransformation, organism-specific biosystem (from WikiPathways)
metapathway biotransformation, organism-specific biosystem
metapathway biotransformation

General gene information

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Markers

ECD05663 (e-PCR)
- UniSTS:286726

WI-12095 (e-PCR)
- UniSTS:16914

ECD03385 (e-PCR)
- UniSTS:284470

ECD13431 (e-PCR)
- UniSTS:294461

GDB:511416 (e-PCR)
- UniSTS:157508

REN45958 (e-PCR)
- UniSTS:370758

REN45959 (e-PCR)
- UniSTS:370759

REN45960 (e-PCR)
- UniSTS:370760

REN45961 (e-PCR)
- UniSTS:370761

REN45962 (e-PCR)
- UniSTS:370762

ECD10107 (e-PCR)
- UniSTS:291147

REN45963 (e-PCR)
- UniSTS:370763

REN45964 (e-PCR)
- UniSTS:370764

REN45965 (e-PCR)
- UniSTS:370765

REN45966 (e-PCR)
- UniSTS:370766

REN45967 (e-PCR)
- UniSTS:370767

ECD18333 (e-PCR)
- UniSTS:299344

REN45968 (e-PCR)
- UniSTS:370768

REN45969 (e-PCR)
- UniSTS:370769

REN45970 (e-PCR)
- UniSTS:370770

REN45971 (e-PCR)
- UniSTS:370771

REN45972 (e-PCR)
- UniSTS:370772

REN45973 (e-PCR)
- UniSTS:370773

REN45974 (e-PCR)
- UniSTS:370774

REN45975 (e-PCR)
- UniSTS:370775

REN45976 (e-PCR)
- UniSTS:370776

REN45977 (e-PCR)
- UniSTS:370777

REN45978 (e-PCR)
- UniSTS:370778

REN45979 (e-PCR)
- UniSTS:370779

REN45980 (e-PCR)
- UniSTS:370780

REN45981 (e-PCR)
- UniSTS:370781

REN45982 (e-PCR)
- UniSTS:370782

REN45983 (e-PCR)
- UniSTS:370783

REN45984 (e-PCR)
- UniSTS:370784

REN45985 (e-PCR)
- UniSTS:370785

RH68970 (e-PCR)
- UniSTS:69731

REN45987 (e-PCR)
- UniSTS:370787

REN45988 (e-PCR)
- UniSTS:370788

REN45989 (e-PCR)
- UniSTS:370789

REN45990 (e-PCR)
- UniSTS:370790

REN45991 (e-PCR)
- UniSTS:370791

REN45992 (e-PCR)
- UniSTS:370792

REN45993 (e-PCR)
- UniSTS:370793

REN45994 (e-PCR)
- UniSTS:370794

REN45995 (e-PCR)
- UniSTS:370795

REN45996 (e-PCR)
- UniSTS:370796

ECD09369 (e-PCR)
- UniSTS:290413

REN45997 (e-PCR)
- UniSTS:370797

REN45998 (e-PCR)
- UniSTS:370798

REN45999 (e-PCR)
- UniSTS:370799

REN46000 (e-PCR)
- UniSTS:370800

REN46001 (e-PCR)
- UniSTS:370801

REN46002 (e-PCR)
- UniSTS:370802

REN46003 (e-PCR)
- UniSTS:370803

REN46004 (e-PCR)
- UniSTS:370804

ECD23517 (e-PCR)
- UniSTS:304501

REN46005 (e-PCR)
- UniSTS:370805

REN46006 (e-PCR)
- UniSTS:370806

REN46007 (e-PCR)
- UniSTS:370807

REN46008 (e-PCR)
- UniSTS:370808

REN46009 (e-PCR)
- UniSTS:370809

REN46010 (e-PCR)
- UniSTS:370810

REN46011 (e-PCR)
- UniSTS:370811

REN46012 (e-PCR)
- UniSTS:370812

REN46013 (e-PCR)
- UniSTS:370813

REN46014 (e-PCR)
- UniSTS:370814

REN46015 (e-PCR)
- UniSTS:370815

REN46016 (e-PCR)
- UniSTS:370816

REN46017 (e-PCR)
- UniSTS:370817

REN46018 (e-PCR)
- UniSTS:370818

ECD05537 (e-PCR)
- UniSTS:286601

ECD19171 (e-PCR)
- UniSTS:300178

RH48302 (e-PCR)
- UniSTS:73619

ECD23043 (e-PCR)
- UniSTS:304027

ECD09161 (e-PCR)
- UniSTS:290206

D2S2843 (e-PCR)
- UniSTS:47278

stSG620144 (e-PCR)
- UniSTS:454070

AFMa057vb1 (e-PCR)
- UniSTS:52424

ECD03538 (e-PCR)
- UniSTS:284620

ECD14611 (e-PCR)
- UniSTS:295631

ECD18210 (e-PCR)
- UniSTS:299221

ECD18237 (e-PCR)
- UniSTS:299248

Genotypes

See UGT1A1 SNP Geneview Report
See UGT1A1 SNP Genotype Report
See UGT1A1 SNP Variation Viewer Report

Homology

Homologs of the UGT1A1 gene: The UGT1A1 gene is conserved in Rhesus monkey, cow, mouse, rat, chicken, zebrafish, fruit fly, and mosquito.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enzyme binding	IDA Inferred from Direct Assay more info
enzyme inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
glucuronosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
glucuronosyltransferase activity	TAS Traceable Author Statement more info
protein heterodimerization activity	IPI Inferred from Physical Interaction more info
protein homodimerization activity	IPI Inferred from Physical Interaction more info
retinoic acid binding	IDA Inferred from Direct Assay more info
steroid binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acute-phase response	IEA Inferred from Electronic Annotation more info
bilirubin conjugation	TAS Traceable Author Statement more info	PubMed
biphenyl catabolic process	IEA Inferred from Electronic Annotation more info
cellular response to ethanol	IEA Inferred from Electronic Annotation more info
cellular response to glucocorticoid stimulus	IEA Inferred from Electronic Annotation more info
digestion	NAS Non-traceable Author Statement more info	PubMed
drug metabolic process	IC Inferred by Curator more info	PubMed
estrogen metabolic process	TAS Traceable Author Statement more info	PubMed
flavone metabolic process	IDA Inferred from Direct Assay more info	PubMed
flavonoid glucuronidation	IDA Inferred from Direct Assay more info
heme catabolic process	TAS Traceable Author Statement more info
heterocycle metabolic process	IC Inferred by Curator more info	PubMed
liver development	IEA Inferred from Electronic Annotation more info
negative regulation of catalytic activity	IDA Inferred from Direct Assay more info	PubMed
negative regulation of steroid metabolic process	IC Inferred by Curator more info	PubMed
organ regeneration	IEA Inferred from Electronic Annotation more info
porphyrin-containing compound metabolic process	TAS Traceable Author Statement more info
response to drug	IEA Inferred from Electronic Annotation more info
response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
response to nutrient	IEA Inferred from Electronic Annotation more info
response to starvation	IEA Inferred from Electronic Annotation more info
retinoic acid metabolic process	IC Inferred by Curator more info
small molecule metabolic process	TAS Traceable Author Statement more info
steroid metabolic process	IC Inferred by Curator more info	PubMed
xenobiotic glucuronidation	IDA Inferred from Direct Assay more info
xenobiotic metabolic process	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
cytochrome complex	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum membrane	TAS Traceable Author Statement more info
integral to plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: UDP-glucuronosyltransferase 1-1

Names: UDP-glucuronosyltransferase 1-1; UGT-1A; UGT1*1; UGT1.1; UGT1-01; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1A1; bilirubin-specific UDPGT isozyme 1; bilirubin UDP-glucuronosyltransferase 1-1; bilirubin UDP-glucuronosyltransferase isozyme 1; UDP glycosyltransferase 1 family, polypeptide A1

NP_000454.1

EC 2.4.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_033238.1 RefSeqGene

Range

5001..18027

Download

GenBank, FASTA, Sequence Viewer (Graphics)
NG_002601.2 RefSeqGene

Range

175530..188556

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000463.2 → NP_000454.1 UDP-glucuronosyltransferase 1-1 precursor

Status: REVIEWED

Source sequence(s)

AY435136, M57899

Consensus CDS

CCDS2510.1

UniProtKB/Swiss-Prot

P22309

UniProtKB/TrEMBL

Q5DT03

Related

ENSP00000304845, OTTHUMP00000065192, ENST00000305208, OTTHUMT00000130982

Conserved Domains (2) summary

cd03784
Location:29 – 444
Blast Score: 313

GT1_Gtf_like; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the ...

pfam00201
Location:28 – 524
Blast Score: 2197

UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p10 Primary Assembly

Range

234668919..234681945

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

226468768..226481779

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018913.1 Alternate CHM1_1.0

Range

234041550..234054578

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01001950.1 (36123..49134)	None
genomic	AC006985.2 (53144..66170)	None
genomic	AF110194.1	AAG43197.1
genomic	AF180372.1	AAF01205.1
genomic	AF297093.1	AAG30424.1
genomic	AF352795.1	AAK31204.1
genomic	AF357220.1	AAK27223.1
genomic	AMYH01011580.1 (34959..47987)	None
genomic	AY603772.1	AAS99732.1
genomic	CH471063.1	EAW71053.1
genomic	D87674.1	BAA25600.1
genomic	DQ374395.1	ABC88474.1
genomic	M84125.1	AAA61248.1
mRNA	AK290834.1	BAF83523.1
mRNA	AY435136.1	AAR95637.1
mRNA	BC128414.1	AAI28415.1
mRNA	BC128415.1	AAI28416.1
mRNA	DQ364247.1	ABC96771.1
mRNA	JQ686667.1	AFH35129.1
mRNA	JQ699637.1	AFN10613.1
mRNA	JQ699638.1	AFN10614.1
mRNA	JQ699639.1	AFN10615.1
mRNA	JQ699640.1	AFN10616.1
mRNA	JQ699641.1	AFN10617.1
mRNA	JQ699642.1	AFN10618.1
mRNA	JQ699643.1	AFN10619.1
mRNA	JQ699644.1	AFN10620.1
mRNA	JQ699645.1	AFN10621.1
mRNA	JQ699646.1	AFN10622.1
mRNA	JQ699647.1	AFN10623.1
mRNA	JQ699649.1	AFN10624.1
mRNA	JQ699650.1	AFN10625.1
mRNA	M57899.1	AAA63195.1