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POU6F1 POU class 6 homeobox 1 [ Homo sapiens (human) ]

Gene ID: 5463, updated on 7-May-2016
Official Symbol
POU6F1provided by HGNC
Official Full Name
POU class 6 homeobox 1provided by HGNC
Primary source
HGNC:HGNC:9224
See related
Ensembl:ENSG00000184271 HPRD:17883; Vega:OTTHUMG00000169622
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRN5; MPOU; TCFB1
Orthologs
Location:
12q13.13
Exon count:
11
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (51186936..51217693, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (51580719..51611477, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene transcription factor CP2 Neighboring gene ribosomal protein L35a pseudogene 29 Neighboring gene prohibitin pseudogene 19 Neighboring gene DAZ associated protein 2 Neighboring gene small cell adhesion glycoprotein Neighboring gene uncharacterized LOC102723983

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of POU class 6 homeobox 1 (POU6F1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor activity, sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
brain development TAS
Traceable Author Statement
more info
PubMed 
heart development TAS
Traceable Author Statement
more info
PubMed 
muscle organ development TAS
Traceable Author Statement
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
POU domain, class 6, transcription factor 1
Names
brain-5
brain-specific homeobox/POU domain protein 5
brn-5
mPOU homeobox protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002702.3NP_002693.3  POU domain, class 6, transcription factor 1

    See identical proteins and their annotated locations for NP_002693.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AC139768, AL832881, AW445212, BC051326, BM703234, CK002954, DA026332, DA084199
    Consensus CDS
    CCDS31803.1
    UniProtKB/Swiss-Prot
    Q14863
    Related
    ENSP00000330190, OTTHUMP00000241714, ENST00000333640, OTTHUMT00000405127
    Conserved Domains (2) summary
    cd00086
    Location:235293
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    cl22952
    Location:139213
    Pou; Pou domain - N-terminal to homeobox domain

RNA

  1. NR_026893.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains additional exons at the 5' end, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC139768, AI417271, AK095191, AL832881, AW445212, BC051326, BM703234, CK002954, DA026332, DA084199

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    51186936..51217693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    51546938..51577697 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)