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    PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) [ Homo sapiens ]

    Gene ID: 54623, updated on 11-May-2012

    Summary

    Official Symbol
    PAF1provided by HGNC
    Official Full Name
    Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)provided by HGNC
    Primary source
    HGNC:25459
    See related
    Ensembl:ENSG00000006712; HPRD:10140; MIM:610506
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PD2; F23149_1; FLJ11123
    Summary
    This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

    Genomic context

    Location :
    19q13.1
    Sequence :
    Chromosome: 19; NC_000019.9 (39876269..39881679, complement)
    See PAF1 in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene glia maturation factor, gamma Neighboring gene sterile alpha motif domain containing 4B Neighboring gene mediator complex subunit 29 Neighboring gene uncharacterized LOC100652940 Neighboring gene zinc finger protein 36, C3H type, homolog (mouse)

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:120081 BioGRID:122724 CDC73    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:120081 BioGRID:115349 CHAF1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120081 BioGRID:107530 CHD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120081 BioGRID:115004 CTR9    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:120081 BioGRID:125817 LEO1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:120081 BioGRID:110443 MLL    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:120081 BioGRID:111426 POLR2A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:120081 BioGRID:111657 PSMA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120081 BioGRID:116780 RTF1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:120081 BioGRID:116367 SUPT16H    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120081 BioGRID:112779 TCEA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:120081 BioGRID:115010 TTC37    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120081 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120081 BioGRID:123255 WDR61    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:120081 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 

    General gene information

    Markers

    Homology

    • Homologs of the PAF1 gene: The PAF1 gene is conserved in dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
     
    Process Evidence Code Pubs
    histone H2B ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone monoubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Cdc73/Paf1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    RNA polymerase II-associated factor 1 homolog
    Names
    RNA polymerase II-associated factor 1 homolog
    pancreatic differentiation protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256826.1NP_001243755.1  RNA polymerase II-associated factor 1 homolog isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK098423, BC000017, BC013402, DA821359
      UniProtKB/Swiss-Prot
      Q8N7H5
      Conserved Domains (1) summary
      pfam03985
      Location:17361
      Blast Score: 1066
      Paf1; Paf1
    2. NM_019088.3NP_061961.2  RNA polymerase II-associated factor 1 homolog isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC000017, DA821359
      Consensus CDS
      CCDS12533.1
      UniProtKB/Swiss-Prot
      Q8N7H5
      Related
      ENSP00000221265, ENST00000221265
      Conserved Domains (1) summary
      pfam03985
      Location:27371
      Blast Score: 1031
      Paf1; Paf1

    RNA

    1. NR_046384.1 RNA Sequence

      Description
      Transcript Variant: This variant (3) lacks an internal exon and includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK294625, BC000017, DA821359

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      39876269..39881679, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      36322971..36328381, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC005239.1 AAC25503.1
    genomic CH471126.1 EAW56880.1
      EAW56881.1
      EAW56882.1
      EAW56883.1
    mRNA AF086555.1 None
    mRNA AJ401156.1 CAC20564.1
    mRNA AK001985.1 BAA92020.1
    mRNA AK098423.1 BAC05305.1
    mRNA AK294625.1 BAG57806.1
    mRNA BC000017.2 AAH00017.1
    mRNA BC013402.1 AAH13402.1
    mRNA DA821359.1 None
    other-genetic DQ891839.2 ABM82765.1
    other-genetic DQ895026.2 ABM85952.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N7H5.2 GenPept UniProtKB/Swiss-Prot:Q8N7H5

      Supplemental Content

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