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NDFIP2 Nedd4 family interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 54602, updated on 26-May-2016
Official Symbol
NDFIP2provided by HGNC
Official Full Name
Nedd4 family interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:18537
See related
Ensembl:ENSG00000102471 HPRD:17629; MIM:610041; Vega:OTTHUMG00000017136
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
N4WBP5A
Orthologs
Location:
13q31.1
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 13 NC_000013.11 (79480722..79556077)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (80055259..80130212)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 26 Neighboring gene RNA, 5S ribosomal pseudogene 33 Neighboring gene uncharacterized LOC105370274 Neighboring gene RBM26 antisense RNA 1 Neighboring gene NDFIP2 antisense RNA 1 Neighboring gene long intergenic non-protein coding RNA 1068 Neighboring gene long intergenic non-protein coding RNA 1038

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
NHGRI GWA Catalog
Genome-wide association study of pancreatic cancer in Japanese population.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ25842, KIAA1165

Gene Ontology Provided by GOA

Function Evidence Code Pubs
WW domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signal transducer activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
metal ion transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
vacuolar transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
multivesicular body membrane IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
NEDD4 family-interacting protein 2
Names
MAPK-activating protein PM04 PM05 PM06 PM07
NEDD4 WW domain-binding protein 5A
NF-kappa-B-activating protein 413
putative MAPK-activating protein PM04/PM05/PM06/PM07
putative NF-kappa-B-activating protein 413

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161407.1NP_001154879.1  NEDD4 family-interacting protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter isoform (2) compared to isoform 1.
    Source sequence(s)
    AK294839, AL136442, AL355603, BM976935
    UniProtKB/TrEMBL
    B4DGY6
    Conserved Domains (1) summary
    pfam10176
    Location:172311
    DUF2370; Protein of unknown function (DUF2370)
  2. NM_019080.2NP_061953.2  NEDD4 family-interacting protein 2 isoform 1

    See identical proteins and their annotated locations for NP_061953.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB097029, AL136442, BM976935, DC320871
    Consensus CDS
    CCDS31998.1
    UniProtKB/Swiss-Prot
    Q9NV92
    Related
    ENSP00000480798, ENST00000612570
    Conserved Domains (1) summary
    pfam10176
    Location:172331
    DUF2370; Protein of unknown function (DUF2370)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p2 Primary Assembly

    Range
    79480722..79556077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719840.2XP_006719903.1  

    Conserved Domains (1) summary
    pfam10176
    Location:171330
    DUF2370; Protein of unknown function (DUF2370)

RNA

  1. XR_245389.2 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018924.2 Alternate CHM1_1.1

    Range
    80022699..80097328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)