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POU4F2 POU class 4 homeobox 2 [ Homo sapiens (human) ]

Gene ID: 5458, updated on 26-May-2016
Official Symbol
POU4F2provided by HGNC
Official Full Name
POU class 4 homeobox 2provided by HGNC
Primary source
HGNC:HGNC:9219
See related
Ensembl:ENSG00000151615 HPRD:00220; MIM:113725; Vega:OTTHUMG00000162045
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRN3B; BRN3.2; Brn-3b
Summary
The protein encoded by this gene is a member of the POU-domain transcription factor family and may be involved in maintaining visual system neurons in the retina. The level of the encoded protein is also elevated in a majority of breast cancers, resulting in accelerated tumor growth. [provided by RefSeq, Sep 2011]
Orthologs
Location:
4q31.2
Exon count:
2
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (146638893..146642471)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (147560045..147563623)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377472 Neighboring gene solute carrier family 10 member 7 Neighboring gene microRNA 7849 Neighboring gene tetratricopeptide repeat domain 29 Neighboring gene uncharacterized LOC105377474 Neighboring gene uncharacterized LOC105377473

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
    Direct p53 effectors, organism-specific biosystem
    Direct p53 effectors
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Regulation of TP53 Activity, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity, organism-specific biosystemProtein stability and transcriptional activity of TP53 (p53) tumor suppressor are regulated by post-translational modifications that include ubiquitination, phosphorylation, acetylation, methylation,...
  • Regulation of TP53 Activity through Association with Co-factors, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity through Association with Co-factors, organism-specific biosystemAssociation of TP53 (p53) with various transcriptional co-factors can promote, inhibit or provide specificity towards either transcription of cell cycle arrest genes or transcription of cell death ge...
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
axon extension IEA
Inferred from Electronic Annotation
more info
 
axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular estrogen receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
neuromuscular process controlling balance IEA
Inferred from Electronic Annotation
more info
 
neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
retina development in camera-type eye ISS
Inferred from Sequence or Structural Similarity
more info
 
retinal ganglion cell axon guidance IEA
Inferred from Electronic Annotation
more info
 
sensory perception of sound IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IC
Inferred by Curator
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
POU domain, class 4, transcription factor 2
Names
Brn3b POU domain transcription factor
POU domain class 4 transcription factor 2
POU domain protein
brain-3B
brain-specific homeobox/POU domain protein 3B

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004575.2NP_004566.2  POU domain, class 4, transcription factor 2

    See identical proteins and their annotated locations for NP_004566.2

    Status: REVIEWED

    Source sequence(s)
    BY796838, DB082745, U06233, X71488
    Consensus CDS
    CCDS34074.1
    UniProtKB/Swiss-Prot
    Q12837
    Related
    ENSP00000281321, OTTHUMP00000221146, ENST00000281321, OTTHUMT00000367020
    Conserved Domains (2) summary
    smart00352
    Location:250327
    POU; Found in Pit-Oct-Unc transcription factors
    cd00086
    Location:346404
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

    Range
    146638893..146642471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 Alternate CHM1_1.1

    Range
    147537342..147540923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)