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    UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 [ Homo sapiens (human) ]

    Gene ID: 54575, updated on 18-May-2013
    Official Symbol
    UGT1A10provided by HGNC
    Official Full Name
    UDP glucuronosyltransferase 1 family, polypeptide A10provided by HGNC
    Primary source
    HGNC:12531
    See related
    Ensembl:ENSG00000242515; HPRD:07336; MIM:606435; Vega:OTTHUMG00000059121
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UDPGT; UGT1J; UGT-1J; UGT1-10; UGT1.10
    Summary
    This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines. [provided by RefSeq, Jul 2008]
    Location :
    2q37
    Sequence :
    Chromosome: 2; NC_000002.11 (234545123..234681951)
    See UGT1A10 in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A12 pseudogene Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A complex locus Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A11 pseudogene Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A8 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A13 pseudogene Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A9 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A7 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A6 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A5 Neighboring gene ribosomal protein L17 pseudogene 11 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A4 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A3 Neighboring gene DnaJ (Hsp40) homolog, subfamily B, member 3 pseudogene Neighboring gene DnaJ (Hsp40) homolog, subfamily B, member 3 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A2 pseudogene Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A1 Neighboring gene maestro heat-like repeat family member 2A Neighboring gene Holliday junction recognition protein

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:120053 BioGRID:106848 APP    BioGRID  PubMed Reconstituted Complex 

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enzyme binding IDA
    Inferred from Direct Assay
    more info
     
    glucuronosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
     
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
     
    protein kinase C binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT retinoic acid binding IDA
    Inferred from Direct Assay
    more info
     
    Process Evidence Code Pubs
    cellular glucuronidation IDA
    Inferred from Direct Assay
    more info
     
    flavone metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metabolic process NAS
    Non-traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    UDP-glucuronosyltransferase 1-10
    Names
    UDP-glucuronosyltransferase 1-10
    UDPGT 1-10
    UDP-glucuronosyltransferase 1-J
    UDP-glucuronosyltransferase 1A10
    UDP glycosyltransferase 1 family, polypeptide A10
    NP_061948.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_002601.2 RefSeqGene

      Range
      51734..188562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_019075.2NP_061948.1  UDP-glucuronosyltransferase 1-10 precursor

      Status: REVIEWED

      Source sequence(s)
      AY435137, BC020971
      Consensus CDS
      CCDS33403.1
      UniProtKB/TrEMBL
      Q5DT02
      UniProtKB/Swiss-Prot
      Q9HAW8
      Related
      ENSP00000343838, OTTHUMP00000065196, ENST00000344644, OTTHUMT00000130986
      Conserved Domains (2) summary
      cd03784
      Location:300441
      Blast Score: 283
      GT1_Gtf_like; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the ...
      pfam00201
      Location:26521
      Blast Score: 2048
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p10 Primary Assembly

      Range
      234545123..234681951
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      226345114..226481785
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018913.1 Alternate CHM1_1.0

      Range
      233917732..234054584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

      Supplemental Content

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