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    ING3 inhibitor of growth family, member 3 [ Homo sapiens (human) ]

    Gene ID: 54556, updated on 14-May-2013
    Official Symbol
    ING3provided by HGNC
    Official Full Name
    inhibitor of growth family, member 3provided by HGNC
    Primary source
    HGNC:14587
    Locus tag
    HSPC301
    See related
    Ensembl:ENSG00000071243; HPRD:06321; MIM:607493; Vega:OTTHUMG00000141270
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Eaf4; ING2; MEAF4; p47ING3
    Summary
    The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008]
    Location :
    7q31
    Sequence :
    Chromosome: 7; NC_000007.13 (120590817..120615711)
    See ING3 in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, Shal-related subfamily, member 2 Neighboring gene tetraspanin 12 Neighboring gene cadherin-like and PC-esterase domain containing 1 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 18 Neighboring gene wingless-type MMTV integration site family, member 16

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Expression and prognostic value of ING3 in human primary hepatocellular carcinoma. Yang HY, et al. Exp Biol Med (Maywood), 2012 Apr. PMID 22550337.
    2. H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization. Bönisch C, et al. Nucleic Acids Res, 2012 Jul. PMID 22467210.
    3. Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK. Lin YY, et al. Nature, 2012 Feb 8. PMID 22318606.
    4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. Oláh J, et al. J Biol Chem, 2011 Sep 30. PMID 21832049.
    5. A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Kim J, et al. Cell, 2010 Oct 15. PMID 20946988.

    See all (26) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. that ING3 may be an important marker for human hepatocellular carcinoma progression and prognosis, as well as a potential therapeutic target.
      Title: Expression and prognostic value of ING3 in human primary hepatocellular carcinoma.
    2. Data show that ING3 is degraded by the ubiquitin-proteasome pathway through the SCF(Skp2) complex.
      Title: The tumor suppressor ING3 is degraded by SCF(Skp2)-mediated ubiquitin-proteasome system.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility.
    4. ING3 would function as a potential tumor suppressor molecule and that low levels of ING3 may indicate an aggressive nature of head and neck cancer.
      Title: Downregulation of ING3 mRNA expression predicts poor prognosis in head and neck cancer.
    5. ING3 may be an important marker for human melanoma progression and prognosis as well as a potential therapeutic target.
      Title: Prognostic significance of nuclear ING3 expression in human cutaneous melanoma.
    6. we have isolated a novel ING family gene, p47ING3, which modulates p53-mediated transcription, cell cycle control, and apoptosis. The p47ING3 gene is located at chromosome 7q31.3 and consists of 12 exons that encode 418 amino acids
      Title: A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control, and apoptosis.
    7. Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers.
      Title: Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    Q9NXR8 P55055 NR1H2    HPRD  PubMed  
    Q9NXR8 Q13133 NR1H3    HPRD  PubMed  
    BioGRID:120041 BioGRID:106601 ACTL6A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:120041 BioGRID:106848 APP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:120041 BioGRID:116108 BRD8    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:120041 BioGRID:114032 CUL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120041 BioGRID:121004 DMAP1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:120041 BioGRID:108309 ELAVL1    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:120041 BioGRID:123227 EPC1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:120041 BioGRID:117564 EPC2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120041 BioGRID:109269 H2AFZ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120041 BioGRID:109315 HDAC1    BioGRID  PubMed Negative Genetic 
    BioGRID:120041 BioGRID:32711 HHT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120041 BioGRID:35796 HHT2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120041 BioGRID:115779 KAT5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:120041 BioGRID:122280 MEAF6    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:120041 BioGRID:116134 MORF4L1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:120041 BioGRID:113222 NR1H2    BioGRID  PubMed Two-hybrid 
    BioGRID:120041 BioGRID:115373 NR1H3    BioGRID  PubMed Two-hybrid 
    BioGRID:120041 BioGRID:115301 RBX1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120041 BioGRID:114166 RUVBL1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:120041 BioGRID:116067 RUVBL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120041 BioGRID:116983 SIRT1    BioGRID  PubMed Negative Genetic 
    BioGRID:120041 BioGRID:116593 SIRT2    BioGRID  PubMed Negative Genetic 
    BioGRID:120041 BioGRID:112393 SKP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120041 BioGRID:113900 TRRAP    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:120041 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:120041 BioGRID:113761 YEATS4    BioGRID  PubMed Affinity Capture-MS 

    Markers

    Genotypes

    Homology

    Clone Names

    • FLJ20089

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    methylated histone residue binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    histone H2A acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    histone H4 acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Piccolo NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Preferred Names
    inhibitor of growth protein 3
    Names
    inhibitor of growth protein 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023322.1 RefSeqGene

      Range
      5001..29895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_019071.2 → NP_061944.2  inhibitor of growth protein 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF074968, AK000096, BU677936, BU684039
      Consensus CDS
      CCDS5778.1
      UniProtKB/Swiss-Prot
      Q9NXR8
      Conserved Domains (2) summary
      pfam00628
      Location:362 – 409
      Blast Score: 138
      PHD; PHD-finger
      pfam12998
      Location:2 – 104
      Blast Score: 336
      ING; Inhibitor of growth proteins N-terminal histone-binding

    2. NM_198267.1 → NP_938008.1  inhibitor of growth protein 3 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses a different segment in its 3' coding region and UTR, compared to variant 1, with a resulting frameshift. The predicted isoform (3) has a distinct and shorter C-terminus, as compared to isoform 1. This transcript is supported by several ESTs, but the predicted ORF has not yet been experimentally confirmed.
      Source sequence(s)
      AK000096, BC009777, CA442734
      Consensus CDS
      CCDS35497.1
      UniProtKB/Swiss-Prot
      Q9NXR8
      Related
      ENSP00000341697, OTTHUMP00000180573, ENST00000339121, OTTHUMT00000280454
      Conserved Domains (1) summary
      pfam12998
      Location:2 – 89
      Blast Score: 219
      ING; Inhibitor of growth proteins N-terminal histone-binding

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p10 Primary Assembly

      Range
      120590817..120615711
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      114954042..114978936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      119985911..120010805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018918.1 Alternate CHM1_1.0

      Range
      123939636..123964532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_198266.1: Suppressed sequence

      Description
      NM_198266.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    genomic AACC02000001.1 (7475653..7500547) None
    genomic ABBA01057764.1 (102841..127735) None
    genomic AC004537.1 AAQ93373.1
      AAQ93374.1
    genomic AMYH01017894.1 (151082..175978) None
    genomic CH236947.1 (7475654..7500548) None
    genomic CH471070.1 EAW83546.1
      EAW83547.1
      EAW83548.1
      EAW83549.1
    mRNA AF074968.1 AAG12172.1
    mRNA AF161419.1 AAF28979.1
    mRNA AF180298.1 AAQ13674.1
    mRNA AK000096.1 BAA90942.1
    mRNA AK291905.1 BAF84594.1
    mRNA AK293682.1 BAG57123.1
    mRNA AY007790.1 AAG23285.1
    mRNA BC009776.1 AAH09776.1
    mRNA BC009777.1 AAH09777.1
    mRNA BC010851.1 AAH10851.1
    mRNA BC062634.1 AAH62634.1
    mRNA BC073865.1 AAH73865.1
    mRNA BC093091.1 AAH93091.1
    mRNA BC093689.1 AAH93689.1
    mRNA BC101609.1 AAI01610.1
    mRNA BC143316.1 AAI43317.1
    mRNA BU677936.1 None
    mRNA BU684039.1 None
    mRNA CA442734.1 None
    mRNA AL603623.1 CAC48260.2
    other-genetic BC146417.1 AAI46418.1
    other-genetic BC153171.1 AAI53172.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NXR8.2 GenPept UniProtKB/Swiss-Prot:Q9NXR8

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
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        3D structure of a gene
      • BioAssay
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      • BioProjects
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      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • GAP
        GAP Links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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