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    ATR ataxia telangiectasia and Rad3 related [ Homo sapiens ]

    Gene ID: 545, updated on 19-May-2012
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    Summary

    Official Symbol
    ATRprovided by HGNC
    Official Full Name
    ataxia telangiectasia and Rad3 relatedprovided by HGNC
    Primary source
    HGNC:882
    See related
    Ensembl:ENSG00000175054; HPRD:08369; MIM:601215; Vega:OTTHUMG00000159234
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FRP1; MEC1; SCKL; FCTCS; SCKL1
    Summary
    The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    3q22-q24
    Sequence :
    Chromosome: 3; NC_000003.11 (142168077..142297668, complement)
    See ATR in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene glycerol kinase 5 (putative) Neighboring gene 5'-3' exoribonuclease 1 Neighboring gene eukaryotic translation initiation factor 2-alpha kinase 1 pseudogene Neighboring gene succinate-CoA ligase, GDP-forming, beta subunit pseudogene Neighboring gene ribosomal protein L6 pseudogene 9 Neighboring gene plastin 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. XPA-mediated regulation of global nucleotide excision repair by ATR Is p53-dependent and occurs primarily in S-phase. Li Z, et al. PLoS One, 2011. PMID 22174788.
    2. WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes. Patro BS, et al. J Cell Sci, 2011 Dec 1. PMID 22159421.
    3. Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint. Lee AY, et al. J Biol Chem, 2012 Jan 20. PMID 22123827.
    4. CtIP Mutations Cause Seckel and Jawad Syndromes. Qvist P, et al. PLoS Genet, 2011 Oct. PMID 21998596.
    5. Differential roles for Chk1 and FANCD2 in ATR-mediated signalling for psoralen photoactivation-induced senescence. Hovest MG, et al. Exp Dermatol, 2011 Nov. PMID 21995812.

    See all (268) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Upon DNA damage in S phase, nucleotide excision repair could be regulated by the ATR/p53-dependent checkpoint via modulation of the XPA nuclear import process.
      Title: XPA-mediated regulation of global nucleotide excision repair by ATR Is p53-dependent and occurs primarily in S-phase.
    2. WRN is involved in the generation of ssDNA and ATR activation in response to camptothecin.
      Title: WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes.
    3. Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint.
      Title: Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint.
    4. Chk1 and FANCD2 function downstream of ATR in a non-redundant manner for the establishment and maintenance of psoralen photoactivation-induced senescence.
      Title: Differential roles for Chk1 and FANCD2 in ATR-mediated signalling for psoralen photoactivation-induced senescence.
    5. Data support a model in which p53 plays an anti-recombinogenic role in the ATR-dependent mammalian replication checkpoint but does not impair a cell's ability to use HR for the removal of DSB induced by cytotoxic agents.
      Title: ATR-p53 restricts homologous recombination in response to replicative stress but does not limit DNA interstrand crosslink repair in lung cancer cells.
    6. we conclude that, despite being a recessively inherited syndrome, the CtIP mutation encodes a dominant negative protein that impairs ATR activation.
      Title: CtIP Mutations Cause Seckel and Jawad Syndromes.
    7. Analysis of mutations that dissociate G(2) and essential S phase functions of human ataxia telangiectasia-mutated and Rad3-related (ATR) protein kinase.
      Title: Analysis of mutations that dissociate G(2) and essential S phase functions of human ataxia telangiectasia-mutated and Rad3-related (ATR) protein kinase.
    8. propose a model in which BID associates with RPA and stimulates the recruitment and/or stabilization of ATR-ATRIP to the DNA damage sensor complex
      Title: BID binds to replication protein A and stimulates ATR function following replicative stress.
    9. ATR is a bona fide hsp90 client protein and post-IR administration of AUY922, by inhibiting ATR-CHK1-mediated DDR, sensitizes cancer cells to IR.
      Title: Hsp90 inhibitor-mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage.
    10. Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase.
      Title: Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase.
    Submit: New GeneRIF Correction See all (158)
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    Phenotypes

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Cutaneous telangiectasia and cancer syndrome, familial

    Seckel syndrome 1

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr induces phosphorylation of replication protein A (RPA32) at serine 4 and 8 in an ATR-dependent manner PubMed
    vpr HIV-1 Vpr-induced apoptosis is mediated via Bax, downstream of ATR activation PubMed
    vpr HIV-1 Vpr activates ATR, resulting in phosphorylation of Chk1 and activation of the ATR-mediated DNA damage response PubMed
    vpr HIV-1 Vpr induces phosphorylation of BRCA1 at serine 1423 in an ATR-dependent manner PubMed
    integrase gag-pol ATR kinase is hypothesized to be required for successful completion of the HIV-1 viral DNA integration process, suggesting a functional interaction with HIV-1 Integrase PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001175.1 AAH02701.1 ATMIN    BIND  PubMed ATR interacts with ASCIZ. This interaction was modeled on a demonstrated interaction between yeast ATR and human ASCIZ. 
    NP_001175.1 NP_009227.1 BRCA1    BIND  PubMed BRCA1 physically and functionally interacts with ATR during genotoxic stress 
    NP_001175.1 NP_001265.1 CHEK1    BIND  PubMed ATR interacts with CHEK1 (CHK1). 
    NP_001175.1 NP_004271.1 EEF1E1    BIND  PubMed p18 interacts with ATR. 
    NP_001175.1 NP_002476.2 NBN    BIND  PubMed NBS1 interacts with ATR. 
    NP_001175.1 NP_002666.1 PML    BIND  PubMed ATR phosphorylates PML. 
    NP_001175.1 NP_005605.1 RHEB    BIND  PubMed ATR interacts with Rheb. 
    NP_001175.1 NP_000537.2 TP53    BIND  PubMed ATR interacts with TP53 (p53). 
    NP_001175.1 NP_066964.1 XRCC5    BIND  PubMed XRCC5 (Ku80) interacts with ATR. 
    Q13535 Q9NY61 AATF    HPRD  PubMed  
    Q13535 Q8WXE1 ATRIP    HPRD  PubMed  
    Q13535 P38398 BRCA1    HPRD  PubMed  
    Q13535 Q14839 CHD4    HPRD  PubMed  
    Q13535 O14757 CHEK1    HPRD  PubMed  
    Q13535 O96017 CHEK2    HPRD  PubMed  
    Q13535 Q9HAW4 CLSPN    HPRD  PubMed  
    Q13535 Q01094 E2F1    HPRD  PubMed  
    Q13535 O43324 EEF1E1    HPRD  PubMed  
    Q13535 P17948 FLT1    HPRD  PubMed  
    Q13535 P35968 KDR    HPRD  PubMed  
    Q13535 P43246 MSH2    HPRD  PubMed  
    Q13535 O60934 NBN    HPRD  PubMed  
    Q13535 O75943 RAD17    HPRD  PubMed  
    Q13535 Q15382 RHEB    HPRD  PubMed  
    Q13535 P04637 TP53    HPRD  PubMed  
    Q13535 P23025 XPA    HPRD  PubMed  
    Q13535 P13010 XRCC5    HPRD  PubMed  
    BioGRID:107027 BioGRID:106543 ABL1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Protein-peptide 
    BioGRID:107027 BioGRID:106671 AP1B1    BioGRID  PubMed Protein-peptide 
    BioGRID:107027 BioGRID:106670 AP2A2    BioGRID  PubMed Protein-peptide 
    BioGRID:107027 BioGRID:114585 ARHGEF1    BioGRID  PubMed Protein-peptide 
    BioGRID:107027 BioGRID:106962 ATM    BioGRID  PubMed Biochemical Activity; Protein-peptide 
    BioGRID:107027 BioGRID:107027 ATR    BioGRID  PubMed Protein-peptide 
    BioGRID:107027 BioGRID:313463 ATRIP    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex 
    BioGRID:107027 BioGRID:107110 BLM    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107027 BioGRID:107140 BRCA1    BioGRID  PubMed Affinity Capture-Western; Protein-peptide; Reconstituted Complex 
    BioGRID:107027 BioGRID:107142 BRCA2    BioGRID  PubMed Protein-peptide 
    BioGRID:107027 BioGRID:124833 C19orf40    BioGRID  PubMed Co-fractionation 
    BioGRID:107027 BioGRID:107426 CDC6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107027 BioGRID:107459 CDK9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107027 BioGRID:116561 CEP164    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:107027 BioGRID:107533 CHD4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107027 BioGRID:107536 CHEK1    BioGRID  PubMed Protein-peptide 
    BioGRID:107027 BioGRID:116369 CHEK2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107027 BioGRID:107607 CLK2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107027 BioGRID:122015 CLSPN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107027 BioGRID:108201 E2F1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107027 BioGRID:108209 E4F1    BioGRID  PubMed Protein-peptide 
    BioGRID:107027 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107027 BioGRID:108472 FANCA    BioGRID  PubMed Biochemical Activity 
    BioGRID:107027 BioGRID:108474 FANCD2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107027 BioGRID:109268 H2AFX    BioGRID  PubMed Co-localization 
    BioGRID:107027 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107027 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:107027 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107027 BioGRID:109540 HSPA4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107027 BioGRID:109596 HUS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107027 BioGRID:110169 LIG4    BioGRID  PubMed Protein-peptide 
    BioGRID:107027 BioGRID:110339 MCM2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107027 BioGRID:110344 MCM7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107027 BioGRID:122776 MCPH1    BioGRID  PubMed Co-localization 
    BioGRID:107027 BioGRID:110501 MRE11A    BioGRID  PubMed Protein-peptide 
    BioGRID:107027 BioGRID:110573 MSH2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:107027 BioGRID:109211 MSH6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107027 BioGRID:114562 MTA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107027 BioGRID:114652 MTA2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107027 BioGRID:110763 NBN    BioGRID  PubMed Affinity Capture-Western; Protein-peptide; Reconstituted Complex 
    BioGRID:107027 BioGRID:115761 NCOA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107027 BioGRID:111075 PA2G4    BioGRID  PubMed Protein-peptide 
    BioGRID:107027 BioGRID:111308 PIK3CA    BioGRID  PubMed Protein-peptide 
    BioGRID:107027 BioGRID:111391 PMS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107027 BioGRID:111420 POLD1    BioGRID  PubMed Protein-peptide 
    BioGRID:107027 BioGRID:131695 POLN    BioGRID  PubMed Biochemical Activity 
    BioGRID:107027 BioGRID:111512 PPP2R2A    BioGRID  PubMed Protein-peptide 
    BioGRID:107027 BioGRID:111769 PTS    BioGRID  PubMed Protein-peptide 
    BioGRID:107027 BioGRID:111771 RAD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107027 BioGRID:111821 RAD17    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Protein-peptide 
    BioGRID:107027 BioGRID:111820 RAD9A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107027 BioGRID:111941 RHEB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107027 BioGRID:112037 RPA1    BioGRID  PubMed Affinity Capture-Western; Protein-peptide 
    BioGRID:107027 BioGRID:112038 RPA2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107027 BioGRID:113871 SMC1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107027 BioGRID:122864 SNIP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107027 BioGRID:115223 TELO2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107027 BioGRID:116256 TOPBP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107027 BioGRID:113010 TP53    BioGRID  PubMed Biochemical Activity; Protein-peptide; Reconstituted Complex 
    BioGRID:107027 BioGRID:115030 TTI1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107027 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107027 BioGRID:111908 UPF1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107027 BioGRID:113323 WRN    BioGRID  PubMed Affinity Capture-Western; Protein-peptide 
    BioGRID:107027 BioGRID:113345 XPC    BioGRID  PubMed Co-localization 
    BioGRID:107027 BioGRID:113353 XRCC5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activation of ATR in response to replication stress, organism-specific biosystem (from REACTOME)
      Activation of ATR in response to replication stress, organism-specific biosystemGenotoxic stress caused by DNA damage or stalled replication forks can lead to genomic instability. To guard against such instability, genotoxically-stressed cells activate checkpoint factors that ha...
    • BARD1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      BARD1 signaling events, organism-specific biosystem
      BARD1 signaling events
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
      Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Chromosome Maintenance, organism-specific biosystem (from REACTOME)
      Chromosome Maintenance, organism-specific biosystemChromosome maintenance is critical for stable chromosome function in mammalian and other eukaryotic cells. Aspects of telomere maintenance and nucleosome assembly are covered here.
    • Circadian rhythm pathway, organism-specific biosystem (from Pathway Interaction Database)
      Circadian rhythm pathway, organism-specific biosystem
      Circadian rhythm pathway
    • DNA Repair, organism-specific biosystem (from REACTOME)
      DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. These cellular mechanisms that must cope with the plethora of DNA base pair ad...
    • Fanconi Anemia pathway, organism-specific biosystem (from REACTOME)
      Fanconi Anemia pathway, organism-specific biosystemFanconi anemia (FA) is a genetic disease of genome instability characterized by congenital skeletal defects, aplastic anemia, susceptibility to leukemias, and cellular sensitivity to DNA damaging age...
    • Fanconi anemia pathway, organism-specific biosystem (from KEGG)
      Fanconi anemia pathway, organism-specific biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
    • Fanconi anemia pathway, conserved biosystem (from KEGG)
      Fanconi anemia pathway, conserved biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
    • G2/M Checkpoints, organism-specific biosystem (from REACTOME)
      G2/M Checkpoints, organism-specific biosystemG2/M checkpoints include the checks for damaged DNA, unreplicated DNA, and checks that ensure that the genome is replicated once and only once per cell cycle. If cells pass these checkpoints, they f...
    • G2/M DNA damage checkpoint, organism-specific biosystem (from REACTOME)
      G2/M DNA damage checkpoint, organism-specific biosystemThroughout the cell cycle, the genome is constantly monitored for damage, resulting either from errors of replication, by-products of metabolism or through extrinsic sources such as ultra-violet or i...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Meiosis, organism-specific biosystem (from REACTOME)
      Meiosis, organism-specific biosystemDuring meiosis the replicated chromosomes of a single diploid cell are segregated into 4 haploid daughter cells by two successive divisions, meiosis I and meiosis II. In meiosis I, the distinguishing...
    • Meiotic Synapsis, organism-specific biosystem (from REACTOME)
      Meiotic Synapsis, organism-specific biosystemMeiotic synapsis is the stable physical pairing of homologous chromosomes that begins in leptonema of prophase I and lasts until anaphase of prophase I. First, short segments of axial elements form a...
    • Regulation of the Fanconi anemia pathway, organism-specific biosystem (from REACTOME)
      Regulation of the Fanconi anemia pathway, organism-specific biosystemThe Fanconi anemia DNA repair pathway is negatively regulated by the deubiquitination of FANCD2 an postively regulated by phosphorylation of the FANCD2 and FANCI. The USP1 deubiquitinating enzyme is...
    • Signaling events mediated by TCPTP, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by TCPTP, organism-specific biosystem
      Signaling events mediated by TCPTP
    • p53 pathway, organism-specific biosystem (from Pathway Interaction Database)
      p53 pathway, organism-specific biosystem
      p53 pathway
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    MutLalpha complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    MutSalpha complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    DNA damage checkpoint IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    DNA repair TAS
    Traceable Author Statement
    more info
    		  
    DNA replication TAS
    Traceable Author Statement
    more info
    		  
    cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cell cycle checkpoint TAS
    Traceable Author Statement
    more info
    		  
    cellular response to UV IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cellular response to gamma radiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    multicellular organismal development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of DNA damage response, signal transduction by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    replicative senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    response to DNA damage stimulus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    PML body IEA
    Inferred from Electronic Annotation
    more info
    		  
    XY body IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    serine/threonine-protein kinase ATR
    Names
    serine/threonine-protein kinase ATR
    protein kinase ATR
    Rad3 related protein
    FRAP-related protein 1
    FRAP-related protein-1
    MEC1, mitosis entry checkpoint 1, homolog
    ataxia telangiectasia and Rad3-related protein
    NP_001175.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008951.1 RefSeqGene

      Range
      5001..134592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184.3 → NP_001175.2  serine/threonine-protein kinase ATR

      Status: REVIEWED

      Source sequence(s)
      BE859077, DC346860, U49844, U76308
      Consensus CDS
      CCDS3124.1
      UniProtKB/Swiss-Prot
      Q13535
      Related
      ENSP00000343741, OTTHUMP00000214450, ENST00000350721, OTTHUMT00000353995
      Conserved Domains (5) summary
      cd00892
      Location:2293 – 2567
      Blast Score: 1246
      PIKKc_ATR; ATR (Ataxia telangiectasia and Rad3-related), catalytic domain; The ATR catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), ...
      cl06893
      Location:1119 – 1224
      Blast Score: 298
      UME; UME (NUC010) domain
      smart00146
      Location:2324 – 2567
      Blast Score: 763
      PI3Kc; Phosphoinositide 3-kinase, catalytic domain
      pfam02259
      Location:1771 – 2092
      Blast Score: 586
      FAT; FAT domain
      pfam02260
      Location:2612 – 2644
      Blast Score: 142
      FATC; FATC domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p5 Primary Assembly

      Range
      142168077..142297668, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      139541210..139670336, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic A61385.1 CAA03590.1
    genomic AC109992.6 (40246..112543) None
    genomic AC134509.2 (2013..59287) None
    genomic AF325699.1 AAK26749.1
    genomic CH471052.2 EAW78969.1
      EAW78970.1
    mRNA AB208847.1 BAD92084.1
    mRNA AK307402.1 None
    mRNA BE859077.1 None
    mRNA DC346860.1 None
    mRNA U49844.1 AAC50405.1
    mRNA U76308.1 AAC50929.1
    mRNA Y09077.1 CAA70298.1
    other-genetic BC172404.1 AAI72404.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13535.3 GenPept UniProtKB/Swiss-Prot:Q13535
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    Additional Links

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