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TMX3 thioredoxin related transmembrane protein 3 [ Homo sapiens (human) ]

Gene ID: 54495, updated on 8-May-2016
Official Symbol
TMX3provided by HGNC
Official Full Name
thioredoxin related transmembrane protein 3provided by HGNC
Primary source
HGNC:HGNC:24718
See related
Ensembl:ENSG00000166479 HPRD:15591; MIM:616102; Vega:OTTHUMG00000172713
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDIA13; TXNDC10
Orthologs
Location:
18q22
Exon count:
19
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 18 NC_000018.10 (68673688..68715298, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (66340925..66382535, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member B10 pseudogene 2 Neighboring gene metallothionein-like 3, pseudogene Neighboring gene uncharacterized LOC105372176 Neighboring gene coiled-coil domain containing 102B Neighboring gene RNA, U6 small nuclear 39, pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: genome-wide association study of both common and rare variants.
NHGRI GWA Catalog
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
    Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
  • Platelet degranulation, organism-specific biosystem (from REACTOME)
    Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
  • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
    Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ20793, KIAA1830

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein disulfide isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
thiol oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 
peptidyl-cysteine oxidation IDA
Inferred from Direct Assay
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
protein folding IBA
Inferred from Biological aspect of Ancestor
more info
 
response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
platelet alpha granule membrane TAS
Traceable Author Statement
more info
 
Preferred Names
protein disulfide-isomerase TMX3
Names
protein disulfide isomerase family A, member 13
thioredoxin domain containing 10
thioredoxin domain-containing protein 10
thioredoxin-related transmembrane protein 3
NP_061895.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019022.3NP_061895.3  protein disulfide-isomerase TMX3 precursor

    See identical proteins and their annotated locations for NP_061895.3

    Status: VALIDATED

    Source sequence(s)
    AL832341, BX647846
    Consensus CDS
    CCDS32840.1
    UniProtKB/Swiss-Prot
    Q96JJ7
    Related
    ENSP00000299608, OTTHUMP00000249181, ENST00000299608, OTTHUMT00000420155
    Conserved Domains (3) summary
    cd03000
    Location:27130
    PDI_a_TMX3; PDIa family, TMX3 subfamily; composed of eukaryotic proteins similar to human TMX3, a TRX related transmembrane protein containing one redox active TRX domain at the N-terminus and a classical ER retrieval sequence for type I transmembrane proteins at ...
    pfam13848
    Location:160337
    Thioredoxin_6; Thioredoxin-like domain
    cl00388
    Location:257340
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p2 Primary Assembly

    Range
    68673688..68715298 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526032.1XP_011524334.1  

    Conserved Domains (2) summary
    pfam13848
    Location:202379
    Thioredoxin_6; Thioredoxin-like domain
    cl00388
    Location:96173
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  2. XM_005266714.1XP_005266771.1  

    See identical proteins and their annotated locations for XP_005266771.1

    Conserved Domains (2) summary
    pfam13848
    Location:19196
    Thioredoxin_6; Thioredoxin-like domain
    cl00388
    Location:116199
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  3. XM_011526033.1XP_011524335.1  

    See identical proteins and their annotated locations for XP_011524335.1

    Conserved Domains (2) summary
    pfam13848
    Location:19196
    Thioredoxin_6; Thioredoxin-like domain
    cl00388
    Location:116199
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  4. XM_011526034.1XP_011524336.1  

    Conserved Domains (1) summary
    cd03000
    Location:27130
    PDI_a_TMX3; PDIa family, TMX3 subfamily; composed of eukaryotic proteins similar to human TMX3, a TRX related transmembrane protein containing one redox active TRX domain at the N-terminus and a classical ER retrieval sequence for type I transmembrane proteins at ...
  5. XM_011526035.1XP_011524337.1  

    Related
    ENSP00000457262, OTTHUMP00000249185, ENST00000562706, OTTHUMT00000420161
    Conserved Domains (1) summary
    cd03000
    Location:27130
    PDI_a_TMX3; PDIa family, TMX3 subfamily; composed of eukaryotic proteins similar to human TMX3, a TRX related transmembrane protein containing one redox active TRX domain at the N-terminus and a classical ER retrieval sequence for type I transmembrane proteins at ...

RNA

  1. XR_935227.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018929.2 Alternate CHM1_1.1

    Range
    66335765..66377203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)