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UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28 [ Homo sapiens (human) ]

Gene ID: 54490, updated on 17-May-2015
Official Symbol
UGT2B28provided by HGNC
Official Full Name
UDP glucuronosyltransferase 2 family, polypeptide B28provided by HGNC
Primary source
HGNC:HGNC:13479
See related
Ensembl:ENSG00000135226; HPRD:05931; MIM:606497; Vega:OTTHUMG00000129401
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Two transcript variants encoding different isoforms have been found for this gene. While both isoforms are targeted to the endoplasmic reticulum, only the longer isoform appears to be active. [provided by RefSeq, May 2011]
See UGT2B28 in MapViewer
Location:
4q13.2
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (69280468..69295050)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (70146217..70160768)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377266 Neighboring gene UDP glucuronosyltransferase 2 family, polypeptide A3 pseudogene Neighboring gene UDP glucuronosyltransferase 2 family, polypeptide A3 pseudogene Neighboring gene UDP glucuronosyltransferase 2 family, polypeptide A3 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glucuronosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
flavonoid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
flavonoid glucuronidation IBA
Inferred from Biological aspect of Ancestor
more info
 
metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
UDP-glucuronosyltransferase 2B28
Names
UDP-glucuronosyltransferase 2B28
UDP glycosyltransferase 2 family, polypeptide B28
UDPGT 2B28
NP_001193933.1
NP_444267.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029527.1 RefSeqGene

    Range
    5001..19552
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001207004.1NP_001193933.1  UDP-glucuronosyltransferase 2B28 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001193933.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two coding exons compared to variant 1, that causes a frameshift.The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF177273
    Consensus CDS
    CCDS56330.1
    UniProtKB/Swiss-Prot
    Q9BY64
    Related
    ENSP00000427399, OTTHUMP00000220488, ENST00000511240, OTTHUMT00000365537
    Conserved Domains (2) summary
    pfam00201
    Location:24335
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
    cl10013
    Location:26333
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
  2. NM_053039.1NP_444267.1  UDP-glucuronosyltransferase 2B28 isoform 1 precursor

    See identical proteins and their annotated locations for NP_444267.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF177272
    Consensus CDS
    CCDS3528.1
    UniProtKB/Swiss-Prot
    Q9BY64
    Related
    ENSP00000334276, OTTHUMP00000159767, ENST00000335568, OTTHUMT00000251557
    Conserved Domains (2) summary
    cd03784
    Location:26441
    GT1_Gtf_like; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the ...
    pfam00201
    Location:24525
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

    Range
    69280468..69295050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532036.1XP_011530338.1  

    Conserved Domains (2) summary
    pfam00201
    Location:24363
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
    cl10013
    Location:26363
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...