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DGCR8 DGCR8 microprocessor complex subunit [ Homo sapiens (human) ]

Gene ID: 54487, updated on 26-May-2016
Official Symbol
DGCR8provided by HGNC
Official Full Name
DGCR8 microprocessor complex subunitprovided by HGNC
Primary source
HGNC:HGNC:2847
See related
Ensembl:ENSG00000128191 HPRD:09913; MIM:609030; Vega:OTTHUMG00000150503
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Gy1; pasha; DGCRK6; C22orf12
Summary
This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Orthologs
Location:
22q11.2
Exon count:
14
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 22 NC_000022.11 (20080232..20111877)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (20067755..20099400)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene catechol-O-methyltransferase Neighboring gene armadillo repeat gene deleted in velocardiofacial syndrome Neighboring gene transport and golgi organization 2 homolog Neighboring gene microRNA 185 Neighboring gene microRNA 3618 Neighboring gene microRNA 1306 Neighboring gene tRNA methyltransferase 2 homolog A Neighboring gene microRNA 6816 Neighboring gene RAN binding protein 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
    Direct p53 effectors, organism-specific biosystem
    Direct p53 effectors
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Gene Silencing by RNA, organism-specific biosystem (from REACTOME)
    Gene Silencing by RNA, organism-specific biosystemIn this module, the biology of various types of regulatory non-coding RNAs are described. Currently, biogenesis and functions of small interfering RNAs (siRNAs) and microRNAs are annotated.
  • MicroRNA (miRNA) biogenesis, organism-specific biosystem (from REACTOME)
    MicroRNA (miRNA) biogenesis, organism-specific biosystemBiogenesis of microRNAs (miRNAs) can be summarized in five steps (reviewed in Ketting 2011, Nowotny and Yang 2009, Kim et al. 2009, Chua et al. 2009, Hannon and He 2004):1. Transcription. miRNA trans...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
heme binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
primary miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ribonuclease III activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
gene silencing by RNA TAS
Traceable Author Statement
more info
 
primary miRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
regulation of stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
microprocessor complex IDA
Inferred from Direct Assay
more info
PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
microprocessor complex subunit DGCR8
Names
DiGeorge syndrome critical region 8
DiGeorge syndrome critical region gene 8

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_022931.1 RefSeqGene

    Range
    5001..36646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001190326.1NP_001177255.1  microprocessor complex subunit DGCR8 isoform 2

    See identical proteins and their annotated locations for NP_001177255.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BC078147, BQ001948, DA433651
    Consensus CDS
    CCDS54501.1
    UniProtKB/Swiss-Prot
    Q8WYQ5
    Related
    ENSP00000372488, ENST00000383024
    Conserved Domains (2) summary
    cd00201
    Location:304332
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00035
    Location:587651
    dsrm; Double-stranded RNA binding motif
  2. NM_022720.6NP_073557.3  microprocessor complex subunit DGCR8 isoform 1

    See identical proteins and their annotated locations for NP_073557.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC006547, BC037564, BQ001948, DA433651
    Consensus CDS
    CCDS13773.1
    UniProtKB/Swiss-Prot
    Q8WYQ5
    Related
    ENSP00000263209, OTTHUMP00000197673, ENST00000351989, OTTHUMT00000318654
    Conserved Domains (3) summary
    cd00048
    Location:513576
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    cd00201
    Location:304332
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00035
    Location:620684
    dsrm; Double-stranded RNA binding motif

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p2 Primary Assembly

    Range
    20080232..20111877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724268.2XP_006724331.1  

    Conserved Domains (2) summary
    cd00048
    Location:156219
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam00035
    Location:263327
    dsrm; Double-stranded RNA binding motif

Alternate CHM1_1.1

Genomic

  1. NC_018933.2 Alternate CHM1_1.1

    Range
    20067440..20099084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)