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    NLE1 notchless homolog 1 (Drosophila) [ Homo sapiens ]

    Gene ID: 54475, updated on 11-May-2012

    Summary

    Official Symbol
    NLE1provided by HGNC
    Official Full Name
    notchless homolog 1 (Drosophila)provided by HGNC
    Primary source
    HGNC:19889
    Locus tag
    HUSSY-07
    See related
    Ensembl:ENSG00000073536; HPRD:16903; Vega:OTTHUMG00000132928
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Nle; FLJ10458

    Genomic context

    Location :
    17q12
    Sequence :
    Chromosome: 17; NC_000017.10 (33458368..33469322, complement)
    See NLE1 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene RAD51L3-RFFL readthrough Neighboring gene RAD51 homolog D (S. cerevisiae) Neighboring gene fibronectin type III domain containing 8 Neighboring gene unc-45 homolog B (C. elegans) Neighboring gene Spi-C transcription factor (Spi-1/PU.1 related) pseudogene

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9NVX2 Q01844 EWSR1    HPRD  PubMed  
    BioGRID:119980 BioGRID:108431 EWSR1    BioGRID  PubMed Two-hybrid 
    BioGRID:119980 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119980 BioGRID:116272 WDR5    BioGRID  PubMed Affinity Capture-Western 

    General gene information

    Markers

    Homology

    • Homologs of the NLE1 gene: The NLE1 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    inner cell mass cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    notchless protein homolog 1
    Names
    notchless protein homolog 1
    Notchless gene homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014445.1NP_001014445.1  notchless protein homolog 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC022916, AJ005257, AK001320, AW451963, BI752930
      Consensus CDS
      CCDS45647.1
      UniProtKB/Swiss-Prot
      Q9NVX2
      Related
      ENSP00000354075, ENST00000360831
      Conserved Domains (1) summary
      cd00200
      Location:50191
      Blast Score: 359
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_018096.3NP_060566.2  notchless protein homolog 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC022916, AJ005257, AK001320, AW451963
      Consensus CDS
      CCDS11291.1
      UniProtKB/Swiss-Prot
      Q9NVX2
      Related
      ENSP00000413572, OTTHUMP00000163848, ENST00000442241, OTTHUMT00000256441
      Conserved Domains (3) summary
      cd00200
      Location:106442
      Blast Score: 633
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08154
      Location:1677
      Blast Score: 198
      NLE; NLE (NUC135) domain
      cl02567
      Location:447483
      Blast Score: 117
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      33458368..33469322, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      29643049..29654013, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC022916.11 (98333..109287) None
    genomic CH471147.2 EAW80165.1
      EAW80166.1
      EAW80167.1
    genomic HC250965.1 CBJ05780.1
    genomic HC311154.1 CBJ21232.1
    mRNA AB209111.1 BAD92348.1
    mRNA AJ005257.1 CAA06444.1
    mRNA AK001320.1 BAA91621.1
    mRNA AK303253.1 BAG64336.1
    mRNA AK304508.1 BAG65315.1
    mRNA AW451963.1 None
    mRNA BC002884.2 AAH02884.2
    mRNA BC012075.1 AAH12075.1
    mRNA BI752930.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NVX2.4 GenPept UniProtKB/Swiss-Prot:Q9NVX2

      Supplemental Content

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