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POR P450 (cytochrome) oxidoreductase [ Homo sapiens (human) ]

Gene ID: 5447, updated on 19-Jul-2014
Official Symbol
PORprovided by HGNC
Official Full Name
P450 (cytochrome) oxidoreductaseprovided by HGNC
Primary source
HGNC:9208
See related
Ensembl:ENSG00000127948; HPRD:00485; MIM:124015; Vega:OTTHUMG00000130413
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPR; CYPOR; P450R
Summary
This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq, Jul 2008]
Location:
7q11.2
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 7 NC_000007.14 (75915102..75986855)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (75544420..75616173)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene THO complex 4 pseudogene Neighboring gene rhomboid domain containing 2 Neighboring gene microRNA 4651 Neighboring gene ribosomal protein L7-like 1 pseudogene 3 Neighboring gene small nucleolar RNA, H/ACA box 14A Neighboring gene transmembrane protein 120A Neighboring gene serine/threonine/tyrosine interacting-like 1 Neighboring gene malate dehydrogenase 2, NAD (mitochondrial)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • 1,25-dihydroxyvitamin D3 biosynthesis, organism-specific biosystem (from BIOCYC)
    1,25-dihydroxyvitamin D3 biosynthesis, organism-specific biosystemGeneral Background Vitamin D occurs in two forms, : VITAMIN_D3 (cholecalciferol) produced in animal skin after exposure to : UV-Light and : Heat, and : VITAMIN_D2 (ergocalciferol) produced in plants...
  • 1,25-dihydroxyvitamin D3 biosynthesis, conserved biosystem (from BIOCYC)
    1,25-dihydroxyvitamin D3 biosynthesis, conserved biosystemGeneral Background Vitamin D occurs in two forms, |FRAME: VITAMIN_D3| (cholecalciferol) produced in animal skin after exposure to |FRAME: UV-Light| and |FRAME: Heat|, and |FRAME: VITAMIN_D2| (ergoca...
  • bile acid biosynthesis, neutral pathway, organism-specific biosystem (from BIOCYC)
    bile acid biosynthesis, neutral pathway, organism-specific biosystemGeneral Background The biosynthesis of bile acids is a major route of : CHOLESTEROL catabolism. It converts the hydrophobic, insoluble : CHOLESTEROL molecule into soluble bile acids. Accumulation ...
  • bile acid biosynthesis, neutral pathway, conserved biosystem (from BIOCYC)
    bile acid biosynthesis, neutral pathway, conserved biosystemGeneral Background The biosynthesis of bile acids is a major route of |FRAME: CHOLESTEROL| catabolism. It converts the hydrophobic, insoluble |FRAME: CHOLESTEROL| molecule into soluble bile acids. ...
  • cytochrome P450, organism-specific biosystem (from WikiPathways)
    cytochrome P450, organism-specific biosystemOxidation of a substrate by Cytochrome P450. Adapted from Niesink et al., Chapter 3, p. 47-48.
  • melatonin degradation I, organism-specific biosystem (from BIOCYC)
    melatonin degradation I, organism-specific biosystemGeneral Background The indoleamine : N-ACETYL-5-METHOXY-TRYPTAMINE is a vertebrate hormone secreted by the pineal gland. It is involved in regulation of circadian and seasonal rhythms. : N-ACETYL-...
  • melatonin degradation I, conserved biosystem (from BIOCYC)
    melatonin degradation I, conserved biosystemGeneral Background The indoleamine |FRAME: N-ACETYL-5-METHOXY-TRYPTAMINE| is a vertebrate hormone secreted by the pineal gland. It is involved in regulation of circadian and seasonal rhythms. |FRA...
  • superpathway of melatonin degradation, conserved biosystem (from BIOCYC)
    superpathway of melatonin degradation, conserved biosystemThe indoleamine |FRAME: N-ACETYL-5-METHOXY-TRYPTAMINE| is a vertebrate hormone secreted by the pineal gland. It is involved in regulation of circadian and seasonal rhythms. |FRAME: N-ACETYL-5-METHO...
  • superpathway of melatonin degradation, organism-specific biosystem (from BIOCYC)
    superpathway of melatonin degradation, organism-specific biosystem
    superpathway of melatonin degradation
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ26468, DKFZp686G04235

Gene Ontology Provided by GOA

Function Evidence Code Pubs
FMN binding IEA
Inferred from Electronic Annotation
more info
 
NADP binding IEA
Inferred from Electronic Annotation
more info
 
NADPH-hemoprotein reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
NADPH-hemoprotein reductase activity TAS
Traceable Author Statement
more info
PubMed 
cytochrome-b5 reductase activity, acting on NAD(P)H IEA
Inferred from Electronic Annotation
more info
 
electron carrier activity IEA
Inferred from Electronic Annotation
more info
 
enzyme binding IEA
Inferred from Electronic Annotation
more info
 
flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
iron-cytochrome-c reductase activity IEA
Inferred from Electronic Annotation
more info
 
nitric oxide dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
 
Process Evidence Code Pubs
carnitine metabolic process IEA
Inferred from Electronic Annotation
more info
 
cellular organofluorine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to follicle-stimulating hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to peptide hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
demethylation IEA
Inferred from Electronic Annotation
more info
 
fatty acid oxidation IEA
Inferred from Electronic Annotation
more info
 
flavonoid metabolic process IEA
Inferred from Electronic Annotation
more info
 
internal peptidyl-lysine acetylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of lipase activity IEA
Inferred from Electronic Annotation
more info
 
nitrate catabolic process IEA
Inferred from Electronic Annotation
more info
 
nitric oxide catabolic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of steroid hormone biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
regulation of growth plate cartilage chondrocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to nutrient IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
NADPH--cytochrome P450 reductase
Names
NADPH--cytochrome P450 reductase
NADPH-dependent cytochrome P450 reductase
NP_000932.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008930.1 

    Range
    5001..76754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000941.2NP_000932.3  NADPH--cytochrome P450 reductase

    See proteins identical to NP_000932.3

    Status: REVIEWED

    Source sequence(s)
    AF258341, AK129978, BC034277, BG104767, BP244929, DA701694
    Consensus CDS
    CCDS5579.1
    UniProtKB/Swiss-Prot
    P16435
    Related
    ENSP00000419970, OTTHUMP00000160964, ENST00000461988, OTTHUMT00000252796
    Conserved Domains (3) summary
    cd06204
    Location:280679
    Blast Score: 1776
    CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
    COG0369
    Location:55679
    Blast Score: 1279
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    pfam00258
    Location:85222
    Blast Score: 374
    Flavodoxin_1; Flavodoxin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000007.14 

    Range
    75915102..75986855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000139.1 

    Range
    70631215..70702985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 

    Range
    75474511..75546243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)