ANKIB1 ankyrin repeat and IBR domain containing 1 [Homo sapiens] - Gene

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Summary

Official Symbol: ANKIB1provided by HGNC
Official Full Name: ankyrin repeat and IBR domain containing 1provided by HGNC
Primary source: HGNC:22215
See related: Ensembl:ENSG00000001629; Vega:OTTHUMG00000155859
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FLJ33123; KIAA1386; DKFZp434A0225

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Genomic context

Location :: 7q21.2

Sequence :: Chromosome: 7; NC_000007.13 (91875548..92030698)

See ANKIB1 in Epigenomics, MapViewer

Chromosome 7 - NC_000007.13 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:119973	BioGRID:111683	PSMD4		BioGRID	PubMed	Biochemical Activity
BioGRID:119973	BioGRID:113164	UBC		BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: ankyrin repeat and IBR domain-containing protein 1

Names: ankyrin repeat and IBR domain-containing protein 1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019004.1 → NP_061877.1 ankyrin repeat and IBR domain-containing protein 1

Status: VALIDATED

Source sequence(s)

AB037807, AC007566, BC063861

Consensus CDS

CCDS47639.1

UniProtKB/Swiss-Prot

Q9P2G1

Related

ENSP00000265742, OTTHUMP00000208793, ENST00000265742, OTTHUMT00000342018

Conserved Domains (5) summary

cd00204
Location:47 – 197
Blast Score: 201

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

smart00647
Location:402 – 478
Blast Score: 142

IBR; In Between Ring fingers

pfam01485
Location:402 – 478
Blast Score: 165

IBR; IBR domain

pfam12796
Location:50 – 175
Blast Score: 128

Ank_2; Ankyrin repeats (3 copies)

cl15348
Location:333 – 379
Blast Score: 103

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000007.13 Reference GRCh37.p5 Primary Assembly

Range

91875548..92030698

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000139.1 Alternate HuRef

Range

86483537..86639103

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CRA_TCAGchr7v2

Genomic

AC_000068.1 Alternate CRA_TCAGchr7v2

Range

91204781..91359905

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC000118.1	None
genomic	AC000120.1 (137075..142195)	None
genomic	AC004539.1	None
genomic	AC007566.2	None
genomic	CH236949.1 (5467104..5623702)	None
genomic	CH471091.2	EAW76852.1
mRNA	AB037807.1	BAA92624.1
mRNA	AK001179.1	BAA91537.1
mRNA	AK025475.1	None
mRNA	AK057685.1	None
mRNA	AL137349.1	CAB70704.1
mRNA	BC031483.1	AAH31483.1
mRNA	BC041643.1	None
mRNA	BC063861.1	AAH63861.1
mRNA	BC073893.1	AAH73893.1
mRNA	BC094865.1	AAH94865.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q4VBX8	GenPept	UniProtKB/TrEMBL:Q4VBX8
Q58F08	GenPept	UniProtKB/TrEMBL:Q58F08
Q9P2G1.3	GenPept	UniProtKB/Swiss-Prot:Q9P2G1