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FBXO42 F-box protein 42 [ Homo sapiens (human) ]

Gene ID: 54455, updated on 26-Jun-2015
Official Symbol
FBXO42provided by HGNC
Official Full Name
F-box protein 42provided by HGNC
Primary source
HGNC:HGNC:29249
See related
Ensembl:ENSG00000037637; MIM:609109; Vega:OTTHUMG00000002218
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JFK; Fbx42
Summary
Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Dec 2010]
Orthologs
See FBXO42 in Epigenomics, MapViewer
Location:
1p36.23-p36.11
Exon count:
11
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (16246840..16352491, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (16573339..16678965, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene REM2 and RAB-like small GTPase 1 Neighboring gene metallothionein 1X pseudogene 1 Neighboring gene ribosomal protein L22 pseudogene 3 Neighboring gene SUZ RNA binding domain containing 1 Neighboring gene spermatogenesis associated 21

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • KIAA1332
Preferred Names
F-box only protein 42
Names
F-box only protein 42
just one F-box and Kelch domain-containing protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018994.2NP_061867.1  F-box only protein 42

    See identical proteins and their annotated locations for NP_061867.1

    Status: VALIDATED

    Source sequence(s)
    AB037753, AW449773, BC063864, DA488838, HY007337
    Consensus CDS
    CCDS30613.1
    UniProtKB/TrEMBL
    A0A024QZB0
    UniProtKB/Swiss-Prot
    Q6P3S6
    Related
    ENSP00000364742, OTTHUMP00000002236, ENST00000375592, OTTHUMT00000006285
    Conserved Domains (5) summary
    pfam12937
    Location:4782
    F-box-like; F-box-like
    pfam13415
    Location:130182
    Kelch_3; Galactose oxidase, central domain
    pfam13418
    Location:282322
    Kelch_4; Galactose oxidase, central domain
    pfam13854
    Location:229268
    Kelch_5; Kelch motif
    sd00038
    Location:119168
    Kelch; KELCH repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    16246840..16352491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006710698.2XP_006710761.1  

    See identical proteins and their annotated locations for XP_006710761.1

    UniProtKB/TrEMBL
    A0A024QZB0
    UniProtKB/Swiss-Prot
    Q6P3S6
    Conserved Domains (5) summary
    pfam12937
    Location:4782
    F-box-like; F-box-like
    pfam13415
    Location:130182
    Kelch_3; Galactose oxidase, central domain
    pfam13418
    Location:282322
    Kelch_4; Galactose oxidase, central domain
    pfam13854
    Location:229268
    Kelch_5; Kelch motif
    sd00038
    Location:119168
    Kelch; KELCH repeat [structural motif]

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    16371929..16477661
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)